scholarly journals Involvement of the Areae Compositae of the Heart in Endemic Pemphigus Foliaceus

2019 ◽  
pp. 181-186
Author(s):  
Ana Maria Abreu-Velez ◽  
Yulieth A. Upegui-Zapata ◽  
Carlos A. Valencia-Yepes ◽  
Eduardo Upegui-Quiceno ◽  
Alejandra M. Jiménez-Echavarría ◽  
...  
Keyword(s):  
Left Ventricular Hypertrophy ◽  
Ventricular Hypertrophy ◽  
Usher Syndrome ◽  
Left Ventricular ◽  
Pemphigus Foliaceus ◽  
New Variant ◽  
Endemic Pemphigus Foliaceus ◽  
Microscopic Studies ◽  
Antigenic Reactivity ◽  
Control Study

Background: A new variant of endemic pemphigus foliaceus in El Bagre (El Bagre-EPF), Colombia, South America, shares features with Senear-Usher syndrome and occurs in an endemic fashion. Patients affected by El Bagre-EPF have heterogeneous antigenic reactivity not only to the skin but to other organs, including the heart. Here we test for autoantibodies to the areae compositaeof the heart (structure consisting of typical desmosomal amalgamated fascia adherensmolecules)and evaluate any possible clinical correlation. Methods: A case-control study comparing 45 patients and 45 controls from the endemic area, matched by demographics including age, gender, weight, work activities, and comorbidities, was performed. Direct and indirect immunofluorescence, immunohistochemistry, confocal microscopic studies, and echocardiogram studies were completed. Results: The main clinical abnormally seen in the El Bagre-EPF patients was left ventricular hypertrophy in 15/45 patients, compared with no such findings in the control population (P < 0.1). Seventy percent of El Bagre-EPF patients and none of the controls displayed polyclonal autoreactivity using different immunoglobulins and complement to the areae compositae of the heart using different methods and antibodies (P < 0.1). Conclusions: Patients affected by El Bagre-EPF demonstrated autoantibodies to the areae compositae of the heart. This finding was associated with left ventricular hypertrophic cardiomyopathy.The areae compositaemay play a role incell junction tension and the El Bagre-EPF patients’ autoantibodies possibly disrupting these junctions and thereby contributing to the left ventricular hypertrophy.

scholarly journals Association of ACE gene D polymorphism with left ventricular hypertrophy in patients with diastolic heart failure: a case–control study

BMJ Open ◽  
2016 ◽  
Vol 6 (2) ◽  
pp. e010282 ◽  
Author(s):  
Ehsan Bahramali ◽  
Mona Rajabi ◽  
Javad Jamshidi ◽  
Seyyed Mohammad Mousavi ◽  
Mehrdad Zarghami ◽  
...  
Keyword(s):  
Heart Failure ◽  
Left Ventricular Hypertrophy ◽  
Ventricular Hypertrophy ◽  
Case Control Study ◽  
Diastolic Heart Failure ◽  
Case Control ◽  
Left Ventricular ◽  
Ace Gene ◽  
Control Study

scholarly journals Evaluation of Indoxyl Sulfate in Chronic Kidney Disease associated with Left Ventricular Hypertrophy

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 3073-3079
Author(s):  
Abdullah H Drewil ◽  
Mohammed A Al-Bayati ◽  
Arif S Malik
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Left Ventricular Hypertrophy ◽  
Ventricular Hypertrophy ◽  
Matched Control ◽  
Left Ventricular ◽  
Indoxyl Sulfate ◽  
Control Group ◽  
Medical City ◽  
Control Study

Chronic kidney disease CKD is widely prevalent globally and Left ventricular hypertrophy (LVH) is very common among CKD patients and contributes to CV mortality which can be monitored by measuring the levels of indoxyl sulfate (IS). Study the correlation of indoxyl sulphate and the degree of left Ventricular hypertrophy in CKD patients. A case control study was done on 90 patients with Chronic kidney disease CKD, 45 of them with who were recruited the Imamian Al-Khadhemian Medical City and Baghedad Hospital, Baghdad, Iraq between January, and September 2020. The levels of indoxyl sulfate and other parameters were measured in the serum of Left ventricular hypertrophy (LVH) and compared with those with a no evidence of LVH) who considered as BMI and sex matched control group. Indoxyl sulfate (IS) levels in patients with chronic kidney disease and an evidence of lift ventricular hypertrophy (LVH-CKD) group were significantly (p=0.001) higher than those of patients with chronic kidney disease without an evidence of lift ventricular hypertrophy (NLVH-CKD) and IS levels were associated significantly with the severity of LVH. The possibility to use IS as a marker for early diagnosis of LVH in patients suffered from CKD and it can be used to determine the severity of LVH in those patients.

scholarly journals Left Ventricular Hypertrophy dan Fungsi Ginjal pada Penderita Hipertensi

2018 ◽  
Vol 1 (2) ◽  
pp. 67
Author(s):  
HERU SULASTOMO ◽  
FADLAN AKHYAR FAUZI ◽  
RATNA KUSUMAWATI
Keyword(s):  
Uric Acid ◽  
Left Ventricular Hypertrophy ◽  
Kidney Function ◽  
Ventricular Hypertrophy ◽  
Case Control Study ◽  
Blood Perfusion ◽  
Left Ventricular ◽  
Chronic Hypertension ◽  
The Subject ◽  
Control Study

Introduction: Chronic hypertension can cause complication such as left ventricular <br />hypertrophy (LVH).  LVH can lead renal artery vasoconstriction, impaire blood perfusion <br />to glomerulus and change glomerulus filtration coeficient. The aim of this study was to<br />compare kidney function between hypertensive patient with LVH and without LVH<br />Methods: This was a case control study that conducted at Dr. Moewardi General<br />Hospital Surakarta. All subjects has been diagnosed as hypertension more than 5 years.<br />The diagnosis of LVH was based on electrocardiography (ECG) result. Kidney function<br />was assessed based on serum ureum, creatinin, and uric acid  levels.<br />Results: The subject of this study was 26 hypertension patients with LVH and 13<br />hypertension patients without LVH. Serum ureum level in patients with LVH was higher<br />than hypertension patients without LVH(24.92 ± 7.99 Vs 32.33±9.91, p= 0.004). Serum<br />uric acid level in hypertension patients with LVH was higher compare to hypertension<br />patients without LVH as well (5.26 ± 1.15 Vs 6.98 ± 1.83, p= 0.029). Whereas serum<br />creatinine levels were not significantly different between two groups of subjects.  <br />Sulastomo et.al., Left Ventricular Hypertrophy dan Fungsi Ginjal pada Penderita Hipertensi <br />Conclusion: : Serum ureum and uric acid levels in hypertensive subjects with LVH are<br />higher than subjects without LVH. There is no difference between serum creatinin level in<br />hypertensive subject with LVH and without LVH.<br /><br /><br />

scholarly journals High Prevalence of Cardiac Valve Disease in Acromegaly: An Observational, Analytical, Case-Control Study

2003 ◽  
Vol 88 (7) ◽  
pp. 3196-3201 ◽  
Author(s):  
Annamaria Colao ◽  
Letizia Spinelli ◽  
Paolo Marzullo ◽  
Rosario Pivonello ◽  
Mario Petretta ◽  
...  
Keyword(s):  
Left Ventricular Hypertrophy ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Cardiac Valve ◽  
Valve Disease ◽  
High Prevalence ◽  
Active Acromegaly ◽  
Cardiac Valve Disease ◽  
Active Controls ◽  
Control Study

To characterize mitral and aortic valve abnormalities we performed M-mode, two-dimensional, and pulsed Doppler echocardiography in 42 patients with active acromegaly, 22 patients cured of acromegaly, and 64 controls pair-matched with the patients for sex and age. The overall prevalence of valve abnormalities was higher in both the active patients (86% vs. 24%; P &lt; 0.0001) and the cured patients (73% vs. 9%; P &lt; 0.0001) than in controls. Left ventricular hypertrophy was higher in active (81% vs. 29%; P &lt; 0.0001), but not in cured (41% vs. 14%; P = 0.09) patients than in controls. Cardiac valve abnormalities were associated with left ventricular hypertrophy in both patients and controls, without any difference between them. Conversely, among subjects without left ventricular hypertrophy, mitral and aortic abnormalities were only present in the patients (75% of active and 54% of cured), but not in controls (3% of active controls and 0% of cured controls). In conclusion, patients with active acromegaly and those cured of the disease have a high prevalence of mitral and aortic abnormalities. The persistence of valve disease in patients with cured acromegaly is likely to be correlated with the persistence of left ventricular hypertrophy, which should be carefully and continuously monitored as an aspect of the risk of cardiac dysfunction in these patients.

Left Ventricular Hypertrophy

2014 ◽  
Vol 19 (2) ◽  
pp. 11-15
Author(s):  
Steven L. Demeter
Keyword(s):  
Risk Factors ◽  
Left Ventricular Hypertrophy ◽  
Ventricular Hypertrophy ◽  
Left Ventricular Mass Index ◽  
Medical Science ◽  
Careful Analysis ◽  
Left Ventricular ◽  
Hypertensive Disease ◽  
Accurate Analysis ◽  
Clear Explanation

Abstract The fourth, fifth, and sixth editions of the AMA Guides to the Evaluation of Permanent Impairment (AMA Guides) use left ventricular hypertrophy (LVH) as a variable to determine impairment caused by hypertensive disease. The issue of LVH, as assessed echocardiographically, is a prime example of medical science being at odds with legal jurisprudence. Some legislatures have allowed any cause of LVH in a hypertensive individual to be an allowed manifestation of hypertensive changes. This situation has arisen because a physician can never say that no component of LVH was not caused by the hypertension, even in an individual with a cardiomyopathy or valvular disorder. This article recommends that evaluators consider three points: if the cause of the LVH is hypertension, is the examinee at maximum medical improvement; is the LVH caused by hypertension or another factor; and, if apportionment is allowed, then a careful analysis of the risk factors for other disorders associated with LVH is necessary. The left ventricular mass index should be present in the echocardiogram report and can guide the interpretation of the alleged LVH; if not present, it should be requested because it facilitates a more accurate analysis. Further, if the cause of the LVH is more likely independent of the hypertension, then careful reasoning and an explanation should be included in the impairment report. If hypertension is only a partial cause, a reasoned analysis and clear explanation of the apportionment are required.

Sign in / Sign up

Export Citation Format

Share Document