Comparison of the clinical efficacy of subcutaneous versus oral administration of methotrexate in patients with psoriasis vulgaris: a randomized controlled trial

2022 ◽  
Author(s):  
Charoen Choonhakarn ◽  
Suteeraporn Chaowattanapanit ◽  
Narachai Julanon ◽  
Panita Limpawattana
Keyword(s):  
Randomized Controlled Trial ◽  
Oral Administration ◽  
Clinical Efficacy ◽  
Psoriasis Vulgaris ◽  
Controlled Trial ◽  
Randomized Controlled

scholarly journals Clinical efficacy of scaling and root planing with and without metronidazole on glycemic control: three-arm randomized controlled trial

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ambrina Qureshi ◽  
Syed Akhtar Hussain Bokhari ◽  
Zeba Haque ◽  
Akhtar Ali Baloch ◽  
Sidra Zaheer
Keyword(s):  
Randomized Controlled Trial ◽  
Glycemic Control ◽  
Clinical Efficacy ◽  
Controlled Trial ◽  
Test Group ◽  
Periodontal Pocket ◽  
Outcome Variable ◽  
Scaling And Root Planing ◽  
Randomized Controlled ◽  
Root Planing

Abstract Background Treating periodontitis through non-surgical periodontal therapy (NSPT) may improve glycemic control in type-2 Diabetes Mellitus (T2DM) patients. However, the evidence to maintain this improvement beyond four months is insufficient. Hence, this trial was conducted to assess clinical efficacy of NSPT on glycemic control in T2DM patients. Methods This three-arm randomized controlled trial recruited 150 known T2DM participants (35–65 years), suffering from moderate to severe periodontitis, having HbA1c level ≥ 6.5% at baseline. Participants were followed up at 3 and 6 months. Intervention for test group-1 included scaling and root planing (SRP) with metronidazole (MET) and oral hygiene instructions (OHI). Test group-2 was intervened with SRP + OHI and control group with OHI only. Stata v. 14 was used to observe inter and intragroup mean changes in glycemic [glycated hemoglobin (HbA1c), fasting blood glucose (FBG)] and periodontal variables [bleeding on probing (BOP), periodontal pocket depth (PPD), clinical attachment loss (CAL)] using ANOVA and RMANOVA. Proportion of change in outcome variable (HbA1c) was assessed between treatment groups using chi-square test. Change was considered significant at p-value ≤ 0.05. Results A significant reduction was observed in BOP, PPD, CAL, HbA1c and FBG over time [p < 0.05]. Significant reductions were observed in same variables in both test groups in comparison to control arm [p < 0.05]. No change between the two test groups was observed [p > 0.05]. Conclusion Scaling and root planing improves glycemic control of T2DM patients independently of the use of MET. Therefore, SRP after every 6 months may be suggested and included as a part of overall diabetes management for patients suffering from T2DM. Clinical trial registration NCT 03,343,366 [Date of Registration: 17/11/2017]

scholarly journals Clinical efficacy of upper limb robotic therapy in people with tetraplegia: a pilot randomized controlled trial

Spinal Cord ◽  
2018 ◽  
Vol 57 (1) ◽  
pp. 49-57 ◽  
Author(s):  
Junsik Kim ◽  
Bum Suk Lee ◽  
Hye-Jin Lee ◽  
Hye-Ri Kim ◽  
Duk-Youn Cho ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Clinical Efficacy ◽  
Upper Limb ◽  
Controlled Trial ◽  
Robotic Therapy ◽  
Randomized Controlled ◽  
Pilot Randomized Controlled Trial

scholarly journals Clinical efficacy of ceramic versus resin-based composite endocrowns in Chinese adults: study protocol for a randomized controlled trial

Trials ◽  
2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Jilei Wang ◽  
Zhiting Ling ◽  
Ziting Zheng ◽  
Chunqing Zheng ◽  
Yawen Gai ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Clinical Efficacy ◽  
Study Protocol ◽  
Controlled Trial ◽  
Chinese Adults ◽  
Randomized Controlled
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