The effect of LH supplementation to the GnRH antagonist protocol in advanced reproductive ageing women: a prospective randomized controlled study

2015 ◽  
Vol 84 (1) ◽  
pp. 99-106 ◽  
Author(s):  
Johnny S. Younis ◽  
Ido Izhaki ◽  
Moshe Ben-Ami
Keyword(s):  
Gnrh Antagonist ◽  
Randomized Controlled Study ◽  
Controlled Study ◽  
Randomized Controlled ◽  
Reproductive Ageing ◽  
Gnrh Antagonist Protocol ◽  
Antagonist Protocol

scholarly journals Evaluation of GnRH antagonist pretreatment before ovarian stimulation in a GnRH antagonist protocol in normal ovulatory women undergoing IVF/ICSI: a randomized controlled trial

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Yisheng Zhang ◽  
Liling Liu ◽  
Jie Qin ◽  
Hongyi Huang ◽  
Lintao Xue ◽  
...  
Keyword(s):  
Pregnancy Rate ◽  
Live Birth ◽  
Pregnancy Outcomes ◽  
Birth Rate ◽  
Gnrh Antagonist ◽  
Live Birth Rate ◽  
Controlled Study ◽  
Randomized Controlled ◽  
Gnrh Antagonist Protocol ◽  
Antagonist Protocol

Abstract Background Synchronization of follicles is key to improving ovulation stimulation with the gonadotropin-releasing hormone (GnRH) antagonist protocol. GnRH antagonist administration in the early follicular phase can quickly decrease gonadotrophin (Gn) levels and achieve downregulation before stimulation, which may improves synchronization. A previous small randomized controlled study (RCT) showed that pretreatment with a GnRH antagonist for 3 days before stimulation may increase oocyte retrieval but cannot increase the pregnancy rate. This study investigated whether the GnRH antagonist pretreatment protocol in ovulatory women can increase the synchronization of follicles and pregnancy outcomes compared with the conventional GnRH antagonist protocol. Methods This RCT included 136 normal ovulatory women undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI). Both groups were treated with recombinant follicle-stimulating hormone (r-FSH) and a flexible GnRH antagonist protocol. The women were randomized into two equal groups with or without GnRH antagonist administration from day 2 of the menstrual cycle for 3 days before stimulation. Our primary outcome was the number of retrieved oocytes. Secondary outcomes included the pregnancy rate and live birth rate. Results Both groups had similar baseline characteristics. The number of retrieved oocytes in the study group was comparable to that in the control group (9.5 [8.0–13.0] vs. 11.0 [7.0–14.8], P = 0.469). There was no significant difference in the follicle size. The fertilization rate, number of good-quality embryos, implantation rate, pregnancy rate, ongoing pregnancy rate, live birth rate per embryonic transfer cycle, and miscarriage rate were similar between the two groups. Conclusion This large RCT analysed GnRH antagonist pretreatment with the GnRH antagonist protocol applied to normal ovulatory women undergoing IVF/ICSI. The number of retrieved oocytes and pregnancy outcomes did not significantly vary. Trial registration Chinese Clinical Trial Registry, ChiCTR1800019730. Registered 26 November 2018.

scholarly journals Administration of corifollitropin alfa on Day 2 versus Day 4 of the cycle in a GnRH antagonist protocol: A randomized controlled pilot study

2014 ◽  
Vol 29 (7) ◽  
pp. 1500-1507 ◽  
Author(s):  
C. Blockeel ◽  
N. P. Polyzos ◽  
L. Derksen ◽  
M. De Brucker ◽  
V. Vloeberghs ◽  
...  
Keyword(s):  
Pilot Study ◽  
Gnrh Antagonist ◽  
Randomized Controlled ◽  
Corifollitropin Alfa ◽  
Gnrh Antagonist Protocol ◽  
Antagonist Protocol
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