Independent association of serum vitamin D with anti-Mullerian hormone levels in women with polycystic ovary syndrome

2018 ◽  
Vol 89 (5) ◽  
pp. 634-641 ◽  
Author(s):  
Ho Yan Queenie Wong ◽  
Hang Wun Raymond Li ◽  
Karen Siu Ling Lam ◽  
Sidney Tam ◽  
Chi Chung Shek ◽  
...  
Nutrients ◽  
2015 ◽  
Vol 7 (6) ◽  
pp. 4555-4577 ◽  
Author(s):  
Chunla He ◽  
Zhoumeng Lin ◽  
Sara Robb ◽  
Amara Ezeamama

2021 ◽  
Vol 2 (11) ◽  
pp. 43-48
Author(s):  
Osama Khalifa ◽  
Esmael ELgarhy ◽  
Fahd Alomda ◽  
Mohamed Yehia

2019 ◽  
Vol 79 (05) ◽  
pp. 510-516 ◽  
Author(s):  
Demet Kokanalı ◽  
Mujdegul Karaca ◽  
Gulnur Ozakşit ◽  
Burak Elmas ◽  
Yaprak Engin Üstün

Abstract Introduction In polycystic ovary syndrome, serum vitamin D levels are known to correlate with metabolic conditions such as diabetes mellitus, metabolic syndrome and cardiovascular disease. However, there are not enough studies showing such a relationship with female fertility. We aimed to compare serum vitamin D levels in fertile and infertile women with polycystic ovary syndrome to evaluate whether vitamin D may play a role in the pathogenesis of fertility problems in women with polycystic ovary syndrome. Materials and Methods 274 infertile and 111 fertile women with polycystic ovary syndrome were included in this retrospective study. Infertile and fertile groups were matched by age, body mass index and homeostasis model assessment of insulin resistance. Anthropometric, clinical and laboratory characteristics of the women were recorded. Serum 25(OH)D3 levels were used to assess serum vitamin D levels. Results No significant differences were detected between groups in terms of anthropometric, clinical and laboratory features except for serum 25(OH)D3 levels and the incidence of vitamin D deficiency. Vitamin D levels were significantly lower and vitamin D deficiency was more common in the infertile group compared to the fertile group. When the groups were stratified into obese/non-obese or insulin resistance positive/negative, infertile obese and infertile insulin resistance-positive women had the lowest serum 25(OH)D3 levels. Conclusion Serum vitamin D levels are lower in infertile women with polycystic ovary syndrome compared to fertile women. When insulin resistance or obesity was present, vitamin D levels were reduced further. Thus, in polycystic ovary syndrome, lower vitamin D levels may play a role in the pathogenesis of fertility problems.


Author(s):  
Justyna Kuliczkowska-Plaksej ◽  
Andrzej Milewicz ◽  
Renato Pasquali ◽  
Agnieszka Lenarcik-Kabzda ◽  
Lukasz Laczmanski ◽  
...  

Author(s):  
Daniela Menichini ◽  
Gianpiero Forte ◽  
Beatrice Orrù ◽  
Giuseppe Gullo ◽  
Vittorio Unfer ◽  
...  

Abstract. Vitamin D is a secosteroid hormone that plays a pivotal role in several metabolic and reproductive pathways in humans. Increasing evidence supports the role of vitamin D deficiency in metabolic disturbances and infertility in women with polycystic ovary syndrome (PCOS). Indeed, supplementation with vitamin D seems to have a beneficial role on insulin resistance and endometrial receptivity. On the other hand, exceedingly high levels of vitamin D appear to play a detrimental role on oocytes development and embryo quality. In the current review, we summarize the available evidence about the topic, aiming to suggest the best supplementation strategy in women with PCOS or, more generally, in those with metabolic disturbances and infertility. Based on the retrieved data, vitamin D seems to have a beneficial role on IR, insulin sensitivity and endometrial receptivity, but high levels and incorrect timing of administration seem to have a detrimental role on oocytes development and embryo quality. Therefore, we encourage a low dose supplementation (400–800 IU/day) particularly in vitamin D deficient women that present metabolic disturbances like PCOS. As far as the reproductive health, we advise vitamin D supplementation in selected populations, only during specific moments of the ovarian cycle, to support the luteal phase. However, ambiguities about dosage and timing of the supplementation still emerge from the clinical studies published to date and further studies are required.


Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 2453-PUB
Author(s):  
SHEN SHANMEI ◽  
LIU JIAYI ◽  
LI YIKUN ◽  
QIAO CHENGCHENG ◽  
YANG JIAMIAO ◽  
...  

Author(s):  
Arfa Azhar ◽  
Ghulam Haider ◽  
Zehra Naseem ◽  
Nida Farooqui ◽  
Mohammad U. Farooqui ◽  
...  

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