Efficacy and safety of bone marrow-derived cell transplantation for spinal cord injury: a systematic review and meta-analysis of clinical trials

2015 ◽  
Vol 29 (9) ◽  
pp. 786-795 ◽  
Author(s):  
Xiao Chuan Li ◽  
Cheng Fan Zhong ◽  
Gui Bin Deng ◽  
Rong Wei Liang ◽  
Chun Ming Huang
Keyword(s):  
Systematic Review ◽  
Spinal Cord ◽  
Bone Marrow ◽  
Spinal Cord Injury ◽  
Clinical Trials ◽  
Cell Transplantation ◽  
Meta Analysis ◽  
Efficacy And Safety ◽  
Cord Injury

scholarly journals Neural stem/progenitor cell transplantation for spinal cord injury treatment; A systematic review and meta-analysis

Neuroscience ◽  
2016 ◽  
Vol 322 ◽  
pp. 377-397 ◽  
Author(s):  
M. Yousefifard ◽  
V. Rahimi-Movaghar ◽  
F. Nasirinezhad ◽  
M. Baikpour ◽  
S. Safari ◽  
...  
Keyword(s):  
Systematic Review ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cell Transplantation ◽  
Progenitor Cell ◽  
Meta Analysis ◽  
Cord Injury ◽  
Injury Treatment

scholarly journals The Efficacy and Safety of Mesenchymal Stem Cell Transplantation for Spinal Cord Injury Patients: A Meta-Analysis and Systematic Review

2018 ◽  
Vol 28 (1) ◽  
pp. 36-46 ◽  
Author(s):  
Panfeng Xu ◽  
Xianliang Yang
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Adverse Effects ◽  
Cell Transplantation ◽  
Meta Analysis ◽  
Urine Volume ◽  
Efficacy And Safety ◽  
Motor Score ◽  
Residual Urine Volume ◽  
Cord Injury

Spinal cord injury (SCI) is a devastating disease, with a high rate of disability. In this meta-analysis, we aimed to comprehensively assess the efficacy and safety of mesenchymal stem cells (MSCs) in treating clinical SCI patients. We systematically searched the PUBMED, EMBASE, Chinese Biomedical (CBM), Web of Science and Cochrane databases using the strategy of combination of free-text words and MeSH terms. The indicators of the American Spinal Injury Association (ASIA) impairment scale (AIS)-grading improvement rate and adverse effects were displayed with an overall relative risk (RR). For the continuous variables of the ASIA motor score, light-touch score, pinprick score, activities of daily living (ADL) score, and residual urine volume, we used odds ratio (OR) to analyze the data. Eleven studies comprising 499 patients meeting all inclusion and exclusion criteria were included. No serious heterogeneity or publication bias was observed across each study. The results showed that significant improvements of total AIS grade (RR: 3.70; P < 0.001), AIS grade A (RR: 3.57; P < 0.001), ASIA sensory score (OR: 8.63; P < 0.001) and reduction of residual urine volume (OR: −36.37; P = 0.03) were observed in experimental group compared with control group. However, no significant differences of motor score (OR: 1.37, P = 0.19) and ADL score (OR: 2.61, P = 0.27) were observed between experimental and control groups. In addition, there were no serious and permanent adverse effects after cell transplantation. Cell transplantation with MSCs is effective and safe in improving the sensory and bladder functions of SCI patients.

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