scholarly journals Retransplanting a previously transplanted kidney ‐ a safe strategy in times of organ shortage?

2021 ◽  
Author(s):  
Hristos Karakizlis ◽  
Marieke Rosmalen ◽  
Philipp Boide ◽  
Ingolf Askevold ◽  
Serge Vogelaar ◽  
...  
Keyword(s):  
Organ Shortage ◽  
Transplanted Kidney ◽  
Safe Strategy

Angiography of transplanted kidney

1977 ◽  
Vol 13 (1) ◽  
pp. 83
Author(s):  
YI Lee ◽  
YW Bahk ◽  
KS Shinn ◽  
HK Park
Keyword(s):  
Transplanted Kidney

Coronary sinus catalase and ceruloplasmin levels predict all-cause mortality in patients with end-stage heart failure awaiting heart transplantation

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
W Szczurek ◽  
M Gasior ◽  
M Skrzypek ◽  
G Kubiak ◽  
A Kuczaj ◽  
...  
Keyword(s):  
Heart Failure ◽  
Heart Transplantation ◽  
Coronary Sinus ◽  
Public Institution ◽  
Funding Source ◽  
Organ Shortage ◽  
Number Of Patients ◽  
End Stage ◽  
Medical University

Abstract   Background, As a consequence of the worldwide increase in life expectancy and due to significant progress in the pharmacological and interventional treatment of heart failure (HF), the proportion of patients that reach an advanced phase of disease is steadily growing. Hence, more and more numerous group of patients is qualified to the heart transplantation (HT), whereas the number of potential heart donors has remained invariable since years. It contributes to deepening in disproportion between the demand for organs which can possibly be transplanted and number of patients awaiting on the HT list. Therefore, accurate identification of patients who are most likely to benefit from HT is imperative due to an organ shortage and perioperative complications. Purpose The aim of this study was to identify the factors associated with reduced survival during a 1.5-year follow-up in patients with end-stage HF awating HT. Method We propectively analysed 85 adult patients with end-stage HF, who were accepted for HT at our institution between 2015 and 2016. During right heart catheterization, 10 ml of coronary sinus blood was additionally collected to determine the panel of oxidative stress markers. Oxidative-antioxidant balance markers included glutathione reductase (GR), glutathione peroxidase (GPx), glutathione transferase (GST), superoxide dismutase (SOD) and its mitochondrial isoenzyme (MnSOD) and cytoplasmic (Cu/ZnSOD), catalase (CAT), malondialdehyde (MDA), hydroperoxides lipid (LPH), lipofuscin (LPS), sulfhydryl groups (SH-), ceruloplasmin (CR). The study protocol was approved by the ethics committee of the Medical University of Silesia in Katowice. The endpoint of the study was mortality from any cause during a 1.5 years follow-up. Results The median age of the patients was 53.0 (43.0–56.0) years and 90.6% of them were male. All included patients were treated optimally in accordance with the guidelines of the European Society of Cardiology. Mortality rate during the follow-up period was 40%. Multivariate logistic regression analysis showed that ceruloplasmin (odds ratio [OR] = 0.745 [0.565–0.981], p=0.0363), catalase (OR = 0.950 [0.915–0.98], p=0.0076), as well as high creatinine levels (OR = 1.071 [1.002–1.144], p=0.0422) were risk factors for death during 1.5 year follow-up. Conclusions Coronary sinus lower ceruloplasmin and catalase levels, as well as higher creatinine level are independently associated with death during 1.5 year follow-up. Funding Acknowledgement Type of funding source: Public Institution(s). Main funding source(s): Medical University of SIlesia, Katowice, POland

scholarly journals Development of strangulation ileus associated with the ureter of the transplanted kidney 18 years after kidney transplantation

2021 ◽  
Author(s):  
Toshihiro Shimizu ◽  
Saki Katano ◽  
Sho Nishida ◽  
Yoshitaka Kinoshita ◽  
Takahiro Shinzato ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Transplanted Kidney ◽  
Strangulation Ileus

scholarly journals Production of Human Pluripotent Stem Cell-Derived Hepatic Cell Lineages and Liver Organoids: Current Status and Potential Applications

2020 ◽  
Vol 7 (2) ◽  
pp. 36 ◽  
Author(s):  
João P. Cotovio ◽  
Tiago G. Fernandes
Keyword(s):  
Cell Types ◽  
In Vitro Models ◽  
Hepatic Cell ◽  
Current Status ◽  
Organ Shortage ◽  
Cell Lineages ◽  
Potential Applications ◽  
Liver Organoids

Liver disease is one of the leading causes of death worldwide, leading to the death of approximately 2 million people per year. Current therapies include orthotopic liver transplantation, however, donor organ shortage remains a great challenge. In addition, the development of novel therapeutics has been limited due to the lack of in vitro models that mimic in vivo liver physiology. Accordingly, hepatic cell lineages derived from human pluripotent stem cells (hPSCs) represent a promising cell source for liver cell therapy, disease modelling, and drug discovery. Moreover, the development of new culture systems bringing together the multiple liver-specific hepatic cell types triggered the development of hPSC-derived liver organoids. Therefore, these human liver-based platforms hold great potential for clinical applications. In this review, the production of the different hepatic cell lineages from hPSCs, including hepatocytes, as well as the emerging strategies to generate hPSC-derived liver organoids will be assessed, while current biomedical applications will be highlighted.

How to Reverse the Organ Shortage

2012 ◽  
Vol 29 (4) ◽  
pp. 344-358 ◽  
Author(s):  
Simon Rippon
Keyword(s):  
Organ Shortage

Primary Cutaneous Plasmacytoma after Rejection of a Transplanted Kidney: Case Report and Review of the Literature

2004 ◽  
Vol 80 (4) ◽  
pp. 361-364 ◽  
Author(s):  
Gianpaolo Tessari ◽  
Fabio Fabbian ◽  
Chiara Colato ◽  
Fabio Benedetti ◽  
Massimo Franchini ◽  
...  
Keyword(s):  
Case Report ◽  
Review Of The Literature ◽  
Transplanted Kidney

Macroporous and nanometre scale fibrous PLA and PLA–HA composite scaffolds fabricated by a bio safe strategy

RSC Advances ◽  
2014 ◽  
Vol 4 (106) ◽  
pp. 61491-61502 ◽  
Author(s):  
Aurelio Salerno ◽  
Mar Fernández-Gutiérrez ◽  
Julio San Román del Barrio ◽  
Concepción Domingo Pascual
Keyword(s):  
Composite Scaffolds ◽  
Safe Strategy
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