National trends and outcomes of Heart‐kidney transplantation using hepatitis c positive donors

Individuals with HIV are at increased risk for ESKD. Kidney transplantation is the best treatment for ESKD in the HIV+ population. Despite reduced access to transplantation, patients who are HIV+ have excellent outcomes and clearly benefit from receiving one. Common post-transplant complications and management concerns, including the optimal antiretroviral regimen, immunosuppression protocols, infectious prophylaxis, hepatitis C coinfection, metabolic complications, and malignancy are all discussed.

Download Full-text

Hepatitis C After Kidney Transplantation

Viral Hepatitis and Liver Disease ◽

10.1007/978-4-431-68255-4_126 ◽

1994 ◽

pp. 491-495 ◽

Cited By ~ 1

Author(s):

Thomas Peters ◽

Wolfgang Grotz ◽

Frank Scheiffele ◽

Hans Berthold ◽

Peter Schollmeyer ◽

...

Keyword(s):

Kidney Transplantation ◽

Hepatitis C

Download Full-text

Outcomes of Heart and Heart-Kidney Transplantation from Hepatitis C Virus (HCV) Positive Donors into HCV Negative Recipients

The Journal of Heart and Lung Transplantation ◽

10.1016/j.healun.2019.01.150 ◽

2019 ◽

Vol 38 (4) ◽

pp. S66-S67 ◽

Cited By ~ 2

Author(s):

S. Aslam ◽

I. Yumul ◽

M. Mariski ◽

V. Pretorius ◽

E. Adler

Keyword(s):

Kidney Transplantation ◽

Hepatitis C Virus ◽

Hepatitis C

Download Full-text

Successful Kidney Transplantation in a Recipient Coinfected with Hepatitis C Genotype 2 and HIV from a Donor Infected with Hepatitis C Genotype 1 in the Direct-Acting Antiviral Era

Case Reports in Hepatology ◽

10.1155/2020/7679147 ◽

2020 ◽

Vol 2020 ◽

pp. 1-6

Author(s):

Dimitrios Farmakiotis ◽

Zoe Weiss ◽

Amy L. Brotherton ◽

Paul Morrissey ◽

Reginald Gohh ◽

...

Keyword(s):

Kidney Transplantation ◽

Hepatitis C ◽

Antiviral Treatment ◽

Holistic Approach ◽

Kidney Graft ◽

Genotype 1 ◽

Direct Acting Antiviral ◽

First Case ◽

Genotype 2 ◽

Transplant Candidates

Despite significant advances in transplantation of HIV-infected individuals, little is known about HIV coinfected patients with hepatitis C virus (HCV) genotypes other than genotype 1, especially when receiving HCV-infected organs with a different genotype. We describe the first case of kidney transplantation in a man coinfected with hepatitis C and HIV in our state. To our knowledge, this is also the first report of an HIV/HCV/HBV tri-infected patient with non-1 (2a) HCV genotype who received an HCV-infected kidney graft with the discordant genotype (1a), to which he converted after transplant. Our case study highlights the following: (1) transplant centers need to monitor wait times for an HCV-infected organ and regularly assess the risk of delaying HCV antiviral treatment for HCV-infected transplant candidates in anticipation of the transplant from an HCV-infected donor; (2) closer monitoring of tacrolimus levels during the early phases of anti-HCV protease inhibitor introduction and discontinuation may be indicated; (3) donor genotype transmission can occur; (4) HIV/HCV coinfected transplant candidates require a holistic approach with emphasis on the cardiovascular risk profile and low threshold for cardiac catheterization as part of their pretransplant evaluation.

Download Full-text