Nicolau syndrome and localized panniculitis: a report of dual diagnoses with an emphasis on morphea profunda-like changes following injection with glatiramer acetate

2016 ◽  
Vol 43 (11) ◽  
pp. 1056-1061 ◽  
Author(s):  
Sarah E. Mott ◽  
Zachary G. Peña ◽  
Rebecca I. Spain ◽  
Kevin P. White ◽  
Benjamin D. Ehst
Keyword(s):  
Glatiramer Acetate ◽  
Nicolau Syndrome ◽  
Dual Diagnoses

scholarly journals Recurrent Nicolau syndrome associated with subcutaneous glatiramer acetate injection—a case report

BMC Neurology ◽  
2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Chiara Zecca ◽  
Carlo Mainetti ◽  
Roland Blum ◽  
Claudio Gobbi
Keyword(s):  
Case Report ◽  
Glatiramer Acetate ◽  
Nicolau Syndrome

scholarly journals Nicolau syndrome after administration of glatiramer acetate

2013 ◽  
Vol 28 (7) ◽  
pp. 448-449
Author(s):  
A. Pulido Pérez ◽  
V. Parra Blanco ◽  
R. Suárez Fernández
Keyword(s):  
Glatiramer Acetate ◽  
Nicolau Syndrome

Nicolau syndrome after glatiramer acetate injection

2015 ◽  
Vol 145 (12) ◽  
pp. e41 ◽  
Author(s):  
Alejandro Lobato-Berezo ◽  
Marcela Martínez-Pérez ◽  
Adrián Imbernón-Moya ◽  
Miguel Ángel Gallego-Valdés
Keyword(s):  
Glatiramer Acetate ◽  
Nicolau Syndrome

scholarly journals Nicolau syndrome following subcutaneous glatiramer acetate injection: A case report and review of the literature

2021 ◽  
Vol 53 (6) ◽  
pp. 489
Author(s):  
Gulsen Akoglu ◽  
Pelin Esme ◽  
Irfan Gahramanov ◽  
Egemen Akıncıoglu
Keyword(s):  
Case Report ◽  
Glatiramer Acetate ◽  
Review Of The Literature ◽  
Nicolau Syndrome

Nicolau Syndrome Secondary to Subcutaneous Glatiramer Acetate Injection

2020 ◽  
pp. 153473462097314
Author(s):  
Caner Demircan ◽  
Neslihan Akdogan ◽  
Leyla Elmas
Keyword(s):  
Glatiramer Acetate ◽  
Rare Complication ◽  
Subcutaneous Administration ◽  
Ulcer Formation ◽  
Injectable Drugs ◽  
Nicolau Syndrome ◽  
Embolia Cutis Medicamentosa ◽  
History Of ◽  
Ulcerative Lesions ◽  
High Index Of Suspicion

Nicolau syndrome, also known as embolia cutis medicamentosa, is a rare complication of injectable drugs. Patients present with pain at injection site, followed by swelling, erythema, purple, hemorrhagic patches and lastly ulcer formation. A variety of intramuscular agents have been implicated as responsible. We report a case of a 26-year-old woman with a history of a purple lesion on her thigh who was diagnosed with Nicolau syndrome due to subcutaneous administration of glatiramer acetate. The patient was followed up with topical mupirocin. On follow-up, although the patient stated that she continued using glatiramer acetate, no new lesions appeared and the existing lesion continued to shrink. Nicolau syndrome seems to have an unpredictable and unavoidable course. This case suggests that physicians should have a high index of suspicion for the presence of Nicolau syndrome in patients presenting with necrotic or ulcerative lesions with a history of using injectable drugs.

Embolia Cutis Medicamentosa (Nicolau Syndrome) After Glatiramer Acetate Injection

2011 ◽  
Vol 102 (9) ◽  
pp. 742-744
Author(s):  
C. Martínez-Morán ◽  
P. Espinosa-Lara ◽  
L. Nájera ◽  
A. Romero-Maté ◽  
S. Córdoba ◽  
...  
Keyword(s):  
Glatiramer Acetate ◽  
Nicolau Syndrome ◽  
Embolia Cutis Medicamentosa

scholarly journals Nicolau Syndrome After Glatiramer Acetate Injection in Close Proximity to Administration of SARS-CoV-2 mRNA Vaccine

2021 ◽  
Vol 9 (1) ◽  
pp. e1112
Author(s):  
Michael Yu Sy ◽  
Erin Fromm ◽  
Linda Doan ◽  
Nathan Rojek ◽  
Alexander Ulrich Brandt
Keyword(s):  
Glatiramer Acetate ◽  
Close Proximity ◽  
Nicolau Syndrome

scholarly journals Case Report: Two Cases of Nicolau Syndrome Associated with Glatiramer Acetate

2017 ◽  
Vol 19 (3) ◽  
pp. 148-150 ◽  
Author(s):  
Dorlan J. Kimbrough ◽  
Scott D. Newsome
Keyword(s):  
Glatiramer Acetate ◽  
Skin Necrosis ◽  
Rare Complication ◽  
Skin Lesions ◽  
Drug Induced ◽  
Length Of Treatment ◽  
Disease Modifying Therapy ◽  
Nicolau Syndrome ◽  
Embolia Cutis Medicamentosa ◽  
Disease Modifying

We report two cases of Nicolau syndrome (embolia cutis medicamentosa), a rare complication of injectable medications, both associated with the administration of 20 mg of subcutaneous glatiramer acetate. Both patients required surgical debridement and were subsequently treated conservatively without additional complications. Patient 1 opted to discontinue disease-modifying therapy. Patient 2 continued glatiramer acetate therapy without complications by using other injection sites. These cases highlight the need for prompt investigation of new unusual skin lesions in patients receiving injectable multiple sclerosis treatments (regardless of length of treatment and previous minor cosmetic concerns) and illustrate the clinical distinction between Nicolau syndrome and drug-induced skin necrosis.

Ten Things We Can Do to Meet the Diverse Needs of Children with Dual Diagnoses

2005 ◽  
Author(s):  
Bernie Fabry ◽  
John J. McGonigle ◽  
Jeanine Rasky ◽  
Martin Lubetsky
Keyword(s):  
Dual Diagnoses
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