Possible causes of a focal esophageal muscle defect

2020 ◽  
Vol 32 (7) ◽  
pp. 1116-1116
Author(s):  
Shiko Kuribayashi ◽  
Hiroyuki Kuwano ◽  
Toshio Uraoka
Keyword(s):  
Muscle Defect ◽  
Esophageal Muscle

scholarly journals Frequency of Herpes Virus (HSV) in Esophageal Muscle Samples among Patients with Achalasia under Heller Myotomy

2021 ◽  
Author(s):  
Tahmaseb Jouzdani ◽  
Amir Sadeghi ◽  
Hamed Tahmasbi ◽  
Ramin Shekouhi ◽  
Maryam Sohooli ◽  
...  
Keyword(s):  
Herpes Virus ◽  
Viral Agent ◽  
Heller’S Myotomy ◽  
History Of ◽  
Heller's Myotomy ◽  
Pcr Method ◽  
Polymerase Chain ◽  
Herpès Virus ◽  
Esophageal Muscle ◽  
Hsv 1

Abstract Background Despite years of research, the etiology of achalasia not well understood. Scientists suppose a role for autoimmunity, in this disorder, and probable viral agent, such as herpes virus (HSV). The aim was to find out the frequency of HSV in esophageal muscle samples in patients with achalasia under Heller's myotomy. Methods In this study, 60 patients with achalasia, after fulfilling the consent form, were underwent Heller’s myotomy surgery. Biopsy samples prepared for polymerase chain reaction (PCR) method for HSV DNA detection. After DNA-extraction, replication performed using specific primers. Results The mean age was 40.62 ± 5.08 years. Thirty-nine patients (65%) were female and 21 (35%) were male. Thirty-eight (63.3%) had no history but the else (36.7%) had a positive history of HSV. HSV-1 was positive in three patients (5%). Two females and one male were HSV-positive. Conclusions HSV-1 frequency is not notable among Iranian patients with achalasia. We suggest exploring other viruses, in special that involving the pathogenesis of achalasia, with a larger sample size.

scholarly journals Activated Eosinophils are Present in Esophageal Muscle in Patients with Achalasia of the Esophagus

2018 ◽  
Vol 24 ◽  
pp. 2377-2383 ◽  
Author(s):  
Hong Jin ◽  
Bin Wang ◽  
Li-li Zhang ◽  
Wei Zhao
Keyword(s):  
Esophageal Muscle

Esophageal muscle tone predicts esophageal sensation a barostat study in patients with functional esophageal disorders and healthy controls

2001 ◽  
Vol 120 (5) ◽  
pp. A220 ◽  
Author(s):  
Yehuda Ringel ◽  
Douglas A. Drossman ◽  
Nicholas J. Shaheen ◽  
Laura E. Keeter ◽  
Kenneth R. Jones ◽  
...  
Keyword(s):  
Muscle Tone ◽  
Healthy Controls ◽  
Esophageal Muscle

Histology and Immunofluorescence of Esophageal Muscle in Achalasia

1988 ◽  
pp. 926-929
Author(s):  
J. A. C. Thorpe ◽  
C. Edwards ◽  
R. A. Thompson ◽  
H. R. Matthews
Keyword(s):  
Esophageal Muscle

scholarly journals Laminin mimetic peptide nanofibers regenerate acute muscle defect

2017 ◽  
Vol 60 ◽  
pp. 190-200 ◽  
Author(s):  
Cagla Eren Cimenci ◽  
Gozde Uzunalli ◽  
Ozge Uysal ◽  
Fatih Yergoz ◽  
Ebru Karaca Umay ◽  
...  
Keyword(s):  
Mimetic Peptide ◽  
Peptide Nanofibers ◽  
Muscle Defect

Antioxidant enzymes in intramural nerves of the opossum esophagus

1996 ◽  
Vol 270 (1) ◽  
pp. G136-G142 ◽  
Author(s):  
R. M. Thomas ◽  
S. Fang ◽  
L. S. Leichus ◽  
L. W. Oberley ◽  
J. Christensen ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Superoxide Dismutase ◽  
Antioxidant Enzymes ◽  
Superoxide Radical ◽  
Muscularis Propria ◽  
Enteric Neurons ◽  
Enzyme Assays ◽  
Nerve Bundles ◽  
Diethyldithiocarbamic Acid ◽  
Esophageal Muscle

Superoxide radical (O2-.) combines with nitric oxide (NO) to form peroxynitrite, thereby nullifying the biological activity of NO. Superoxide dismutase (SOD) prevents this reaction by converting O2-. to H2O2. We tested the hypotheses that the antioxidant enzymes catalase (CAT), Mn SOD, and Cu/Zn SOD are present in enteric neurons of the opossum esophagus, and that O2-. alters esophageal motor function. Immunostaining demonstrated CAT, Mn SOD, and Cu/Zn SOD immunoreactivity in interganglionic nerve bundles and ganglia of the myenteric and submucosal plexuses. Western blot analysis confirmed the presence of these enzymes in homogenates of esophageal muscularis propria, and enzyme assays demonstrated Cu/Zn SOD and Mn SOD activities of 262 and 73 U/mg protein, respectively. Both diethyldithiocarbamic acid, an inhibitor of Cu/Zn SOD, and xanthine (X) with xanthine oxidase (XO), which generate O2-., shortened the latency of the nerve-mediated contraction of circular esophageal muscle, the off response, by 20.2 and 23.4%, respectively. SOD alone did not affect the latency, but it inhibited the effect of X with XO on the latency. Antioxidant enzymes found in intramural esophageal nerves may play a role in regulating NO-mediated neuromuscular communication in the esophagus.

Force-velocity characteristics of esophageal muscle: effect of acetylcholine and norepinephrine

1974 ◽  
Vol 226 (5) ◽  
pp. 1250-1256 ◽  
Author(s):  
S Cohen ◽  
F Green
Keyword(s):  
Force Velocity ◽  
Esophageal Muscle

scholarly journals Clinical impact of peroral endoscopic myotomy for esophageal motility disorders on esophageal muscle layer thickness

2019 ◽  
Vol 07 (04) ◽  
pp. E525-E532
Author(s):  
Daisuke Watanabe ◽  
Shinwa Tanaka ◽  
Fumiaki Kawara ◽  
Hirohumi Abe ◽  
Ryusuke Ariyoshi ◽  
...  
Keyword(s):  
Layer Thickness ◽  
Esophageal Motility ◽  
Circular Muscle ◽  
Muscle Layer ◽  
Peroral Endoscopic Myotomy ◽  
Esophageal Motility Disorders ◽  
Pathological Features ◽  
Motility Disorders ◽  
Endoscopic Myotomy ◽  
Esophageal Muscle

Abstract Background and study aims Previously, we reported that esophageal muscle layer thickness was associated with technical complexity of peroral endoscopic myotomy (POEM). However, there are no data regarding the mid-term effects of POEM procedures on esophageal muscle layer thickness. Therefore, we conducted this study to elucidate mid-term effects of POEM procedures, and to examine whether postoperative changes in esophageal muscle layer thickness were related to particular clinico-pathological features in patients with esophageal motility disorders. Patients and methods Seventy-four consecutive patients with esophageal motility disorders who underwent POEM at Kobe University Hospital from April 2015 to December 2016 were prospectively recruited into this study. First, we investigated the esophageal muscle layer thickness values obtained at 1 year after POEM. Second, we evaluated the effects of a reduction in muscle layer thickness on various clinico-pathological features. Results At 1 year after POEM, mean thickness of the inner circular muscle at 0 cm, 5 cm, and 10 cm from the esophagogastric junction was 1.06 ± 0.45 mm, 0.99 ± 0.36 mm, and 0.97 ± 0.44 mm, respectively. Among all sites, muscle layer thickness had significantly decreased after POEM. However, univariate logistic regression analysis demonstrated that no clinical factors were associated with esophageal muscle layer thickness after POEM procedure. Conclusions We demonstrated for the first time that thickness of the esophageal muscle layer was significantly decreased after POEM. This result reveals that changes in esophageal muscle layer thickness caused by esophageal motility disorders are reversible.

Evidence for Developmentally Programmed Transdifferentiation in Mouse Esophageal Muscle

Science ◽  
1995 ◽  
Vol 270 (5243) ◽  
pp. 1818-1821 ◽  
Author(s):  
A. Patapoutian ◽  
B. J. Wold ◽  
R. A. Wagner
Keyword(s):  
Esophageal Muscle

Characterization of vagal input to the rat esophageal muscle

2001 ◽  
Vol 91 (1-2) ◽  
pp. 1-9 ◽  
Author(s):  
Martin Storr ◽  
Fabian Geisler ◽  
Winfried L. Neuhuber ◽  
Volker Schusdziarra ◽  
Hans D. Allescher
Keyword(s):  
Esophageal Muscle
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