scholarly journals Impact of tranexamic acid use on blood loss and transfusion rates following VDRO in children with cerebral palsy

2018 ◽  
Vol 60 ◽  
pp. 7-7
Keyword(s):  
Cerebral Palsy ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Children With Cerebral Palsy

scholarly journals The Value of Tranexamic Acid in Reducing Blood Loss following Hip Reconstruction in Children with Cerebral Palsy

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
I. Majid ◽  
S. Alshryda ◽  
B. Somanchi ◽  
E. Morakis ◽  
A. Foster
Keyword(s):  
Cerebral Palsy ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Controlled Trial ◽  
Statistical Significance ◽  
Transfusion Rate ◽  
Hip Reconstruction ◽  
Children With Cerebral Palsy ◽  
Paediatric Orthopaedic ◽  
Randomised Controlled

This is a retrospective study of 51 consecutive hip reconstructions in children with cerebral palsy performed between 2011 and 2013. Tranexamic acid (TXA) was used in 14 hip reconstructions only. Transfusion rate was higher, postoperative Hb was lower, and patients stayed longer in the TXA group. This did not reach a statistical significance (P = 0.75, 0.5, and 0.71, resp.). More than half of the patients who had TXA underwent bilateral hip reconstructions in comparison with 27% only in the non-TXA group. Bilateral hip reconstructions mean more surgery, more blood loss, and more blood transfusion. The patients who had TXA were significantly more disabled as evident by the higher proportions of patient with worse GMFCS levels. Although we have not been able to demonstrate the value of TXA in reducing blood loss and transfusion rate in children with CP who underwent hip reconstruction, it is hoped that an interest in exploring the value of TXA in paediatric orthopaedic surgery is generated. Ideally this should be explored further in an adequately powered, randomised controlled trial where risk of bias is minimized.

scholarly journals Impact of tranexamic acid use on blood loss and transfusion rates following femoral varus derotational osteotomy in children with cerebral palsy

2019 ◽  
Vol 13 (2) ◽  
pp. 190-195 ◽  
Author(s):  
A. Nazareth ◽  
S. J. Shymon ◽  
L. Andras ◽  
R. Y. Goldstein ◽  
R. M. Kay
Keyword(s):  
Cerebral Palsy ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Thromboembolic Complications ◽  
Safety And Efficacy ◽  
Estimated Blood Loss ◽  
Transfusion Requirements ◽  
Derotational Osteotomy ◽  
Venous Thromboembolic Events ◽  
Children With Cerebral Palsy

Purpose Previous studies have established the safety and efficacy of tranexamic acid (TXA) in reducing blood loss after total joint arthroplasty and spinal fusion surgery; however, literature regarding the effectiveness of intraoperative TXA in children with cerebral palsy (CP) is limited. The aim of this study was to investigate the safety and efficacy of intraoperative TXA in reducing blood loss and transfusion requirements for children with CP undergoing a proximal femoral varus derotational osteotomy (VDRO). Methods This is a retrospective review of 258 children with CP who underwent VDRO performed at the author’s institution between 2004 and 2017. In all, 36 subjects underwent VDRO surgery with administration of intravenous TXA and 222 subjects underwent VDRO without administration of TXA. Outcome measures including blood loss, transfusion requirements and venous thromboembolic events were compared between groups using t-tests and chi-squared tests. Results No significant differences were seen in the rates of transfusion between groups for the entire hospitalization (TXA group: 11.1% versus No TXA group: 19.8%), intraoperatively (TXA: 2.8% versus No TXA: 9.0%) or postoperatively (TXA: 8.3% versus No TXA: 14.4%). Intraoperative estimated blood loss (TXA: 144.4 mL versus No TXA: 159.0 mL) and percentage blood loss (TXA: 8.9% versus No TXA: 9.2%) were similar between groups. No major thromboembolic complications events occurred in either group. Conclusion The use of TXA was not associated with thromboembolic complications in this series of children with CP undergoing VDRO surgery. Though there was a trend toward lower rates of intraoperative and postoperative blood transfusion with TXA use in these patients, the differences were not significant, possibly due to low estimated blood loss in both groups and sample size. Level of evidence III- retrospective comparative study

scholarly journals Tranexamic acid use decreases transfusion rate in children with cerebral palsy undergoing proximal femoral varus derotational osteotomy

Medicine ◽  
2022 ◽  
Vol 101 (2) ◽  
pp. e28506
Author(s):  
Edward Compton ◽  
Rachel Y. Goldstein ◽  
Alexander Nazareth ◽  
Stephen J. Shymon ◽  
Lydia Andras ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Tranexamic Acid ◽  
Transfusion Rate ◽  
Derotational Osteotomy ◽  
Children With Cerebral Palsy

Are Antifibrinolytics Helpful in Decreasing Blood Loss and Transfusions During Spinal Fusion Surgery in Children With Cerebral Palsy Scoliosis?

Spine ◽  
2012 ◽  
Vol 37 (9) ◽  
pp. E549-E555 ◽  
Author(s):  
Arjun A. Dhawale ◽  
Suken A. Shah ◽  
Paul D. Sponseller ◽  
Tracey Bastrom ◽  
Geraldine Neiss ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Blood Loss ◽  
Spinal Fusion ◽  
Fusion Surgery ◽  
Spinal Fusion Surgery ◽  
Children With Cerebral Palsy

Prevalence of Speech Problems and the Use of Augmentative and Alternative Communication in Children With Cerebral Palsy: A Registry-Based Study in Norway

2010 ◽  
Vol 19 (1) ◽  
pp. 12-20 ◽  
Author(s):  
Guro Andersen ◽  
Tone R. Mjøen ◽  
Torstein Vik
Keyword(s):  
Cerebral Palsy ◽  
Motor Function ◽  
Gestational Age ◽  
Augmentative And Alternative Communication ◽  
Alternative Communication ◽  
Gross Motor ◽  
Gross Motor Function ◽  
Children With Cerebral Palsy ◽  
Communicative Abilities ◽  
Normal Speech

Abstract This study describes the prevalence of speech problems and the use of augmentative and alternative communication (AAC) in children with cerebral palsy (CP) in Norway. Information on the communicative abilities of 564 children with CP born 1996–2003, recorded in the Norwegian CP Registry, was collected. A total of 270 children (48%) had normal speech, 90 (16%) had slightly indistinct speech, 52 (9%) had indistinct speech, 35 (6%) had very indistinct speech, 110 children (19%) had no speech, and 7 (1%) were unknown. Speech problems were most common in children with dyskinetic CP (92 %), in children with the most severe gross motor function impairments and among children being totally dependent on assistance in feeding or tube-fed children. A higher proportion of children born at term had speech problems when compared with children born before 32 weeks of gestational age 32 (p > 0.001). Among the 197 children with speech problems only, 106 (54%) used AAC in some form. Approximately 20% of children had no verbal speech, whereas ~15% had significant speech problems. Among children with either significant speech problems or no speech, only 54% used AAC in any form.

Sign in / Sign up

Export Citation Format

Share Document