Comparison of the efficacy and safety of intralesional injection of tranexamic acid and the topical application of Kligman combination drug in the treatment of macular amyloidosis

2021 ◽  
Author(s):  
Mohammadreza Ghassemi ◽  
Masoumeh Roohaninasab ◽  
Seyed Abolfazl Kamani ◽  
Afsaneh Sadeghzadeh‐Bazargan ◽  
Azadeh Goodarzi
Keyword(s):  
Tranexamic Acid ◽  
Topical Application ◽  
Intralesional Injection ◽  
Efficacy And Safety ◽  
Combination Drug ◽  
Macular Amyloidosis

Efficacy and safety of the topical application of tranexamic acid in primary cementless hip arthroplasty: Prospective, randomised, double-blind and controlled study

2018 ◽  
Vol 62 (1) ◽  
pp. 47-54
Author(s):  
F.J. Tavares Sánchez-Monge ◽  
I. Aguado Maestro ◽  
A. Bañuelos Díaz ◽  
M.Á. Martín Ferrero ◽  
M.F. García Alonso
Keyword(s):  
Tranexamic Acid ◽  
Topical Application ◽  
Hip Arthroplasty ◽  
Controlled Study ◽  
Efficacy And Safety ◽  
Double Blind ◽  
Cementless Hip Arthroplasty

In Reply to the Letter to the Editor Regarding “Cytotoxicity and Effect of Topical Application of Tranexamic Acid on Human Fibroblast in Spine Surgery”

2022 ◽  
Vol 157 ◽  
pp. 261
Author(s):  
Feng Wang ◽  
Shu-guang Wang ◽  
Qian Yang ◽  
Li-Ping Nan ◽  
Tong-Chuan Cai ◽  
...  
Keyword(s):  
Tranexamic Acid ◽  
Spine Surgery ◽  
Topical Application ◽  
Human Fibroblast ◽  
Letter To The Editor

Letter to the Editor Regarding “Cytotoxicity and Effect of Topical Application of Tranexamic Acid on Human Fibroblast in Spine Surgery”

2022 ◽  
Vol 157 ◽  
pp. 260
Author(s):  
Kjersti Ausen ◽  
Tuva Eikebrokk ◽  
Brita Vassmyr ◽  
Caroline Gravastrand ◽  
Olav Spigset ◽  
...  
Keyword(s):  
Tranexamic Acid ◽  
Spine Surgery ◽  
Topical Application ◽  
Human Fibroblast ◽  
Letter To The Editor

scholarly journals The Efficacy and Safety of Fibrin Sealant Versus Tranexamic Acid Administration in Patients Undergoing Hip Arthroplasty: A Meta-analysis

2020 ◽  
Author(s):  
Fan Yong Yong ◽  
deng bo ◽  
Hong Hai Nan ◽  
Zhu Zhong
Keyword(s):  
Blood Loss ◽  
Tranexamic Acid ◽  
Randomized Controlled Trials ◽  
Hip Arthroplasty ◽  
Fibrin Sealant ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Transfusion Rate ◽  
Efficacy And Safety ◽  
Randomized Controlled

Abstract PurposeThe efficacy and safety of topical fibrin sealant (FS) compared with tranexamic acid (TXA) to reduce blood loss after total hip arthroplasty (THA) is not clear. A meta-analysis was conducted to evaluate the efficacy and safety of topical FS versus topical or intravenous TXA for treatment of primary THA.MethodWe searched electronic databases, including PubMed, Embase, and the Cochrane Library to identify studies up to March 2020. The references included in articles were also checked for additional potentially-relevant studies. The language of publication was limited to English. The endpoints included the mean difference (MD) of blood loss, hemoglobin value, and odds ratios (ORs) of transfusion requirements and thrombotic events. Our meta-analysis was performed according to the Guidelines of the Cochrane Reviewer's Handbook and the PRISMA statement. The data of the included studies were analyzed using RevMan 5.3.ResultsA total of four studies (two randomized controlled trials and two non-randomized controlled trials) met the inclusion criteria. Our meta-analysis demonstrated that TXA administration led to significantly different outcomes in terms of transfusion rate (RD = -0.12, 95% CI (-0.23, -0.00), P = 0.05, I2 = 74%) and postoperative hemoglobin levels (WMD = -0.47, 95% CI (-0.74, -021), P = 0.0005, I2 = 3%) compared with topical application of FS in patients undergoing THA. No significant difference was seen in total calculated blood loss (WMD = -86.22, 95% CI (-99.13, -73.31), P < 0.00001, I2 = 96%) or complication rate (RR = 0.98, 95% CI (-99.13, -73.31), P = 0.45, I2 = 0%) between the two groups.ConclusionsTXA administration can effectively decrease the transfusion rate and result in higher postoperative hemoglobin levels without increasing the rate of infection.

Efficacy and Safety of Tranexamic Acid in Resection and Endoprosthetic Reconstruction of Distal Femoral Osteosarcomas in Children

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Omer Sofulu ◽  
Ozer Ozturk ◽  
Murat Polat ◽  
Omer Buyuktopcu ◽  
Mehmet D. Kesimer ◽  
...  
Keyword(s):  
Tranexamic Acid ◽  
Efficacy And Safety ◽  
Endoprosthetic Reconstruction

scholarly journals Evaluation of Therapeutic Efficacy and Safety of Tranexamic Acid Local Infiltration in Combination with Topical 4% Hydroquinone Cream Compared to Topical 4% Hydroquinone Cream Alone in Patients with Melasma: A Split-Face Study

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Zohreh Tehranchinia ◽  
Bita Saghi ◽  
Hoda Rahimi
Keyword(s):  
Tranexamic Acid ◽  
Efficacy And Safety ◽  
Local Infiltration ◽  
Patient’S Satisfaction ◽  
Treatment Groups ◽  
Exposed Skin ◽  
Therapeutic Outcomes ◽  
Satisfaction With Treatment ◽  
The Difference ◽  
Split Face

Introduction. Melasma is an acquired pigmentary disorder characterized by hyperpigmented macules and/or patches affecting sun-exposed skin. Tranexamic acid (TA) can reduce melanin content of epidermis. Thus, we conducted this study to evaluate the efficacy and safety of tranexamic acid local infiltration in combination with topical 4% hydroquinone cream compared to topical 4% hydroquinone cream alone in patients with melasma.Material and Methods. This study was a prospective assessor- and analyst-blind, randomized split-face clinical trial which was performed on patients with bilateral malar epidermal melasma. A total of 55 patients were enrolled, and each side of their face was randomly allocated to either TA+HQ or HQ alone treatment. The MASI score was applied as an objective measurement to compare two treatment groups. The patient's satisfaction of melasma treatment was evaluated using a four-scale grading, as well.Results. The mean of MASI score in week 16 decreased in both groups significantly (p < 0.01). The therapeutic outcomes were significantly better in TA+HQ group than HQ group (p=0.001). Patients satisfaction with treatment was significantly higher in the TA + HQ group. The difference between the two groups regarding side effect occurrence was not statistically significant.Conclusion. Addition of tranexamic acid injections to conventional hydroquinone therapy can increase the efficacy of topical treatment.This trial is registered withIRCT2015110324865N1.

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