Long-lasting marked inhibition of periaqueductal gray-evoked defensive behaviors in inescapably-shocked rats

2013 ◽  
Vol 39 (2) ◽  
pp. 275-286 ◽  
Author(s):  
Jeyce W. Quintino-dos-Santos ◽  
Cláudia J. T. Müller ◽  
Alexandre M. C. Santos ◽  
Sérgio Tufik ◽  
Caroline A. Rosa ◽  
...  
Keyword(s):  
Periaqueductal Gray ◽  
Marked Inhibition ◽  
Defensive Behaviors

Corrigendum to “Serotonin in the dorsal periaqueductal gray inhibits panic-like defensive behaviors in rats exposed to acute hypoxia” [Neuroscience 307 (2015) 191–198]

Neuroscience ◽  
2015 ◽  
Vol 310 ◽  
pp. 752
Author(s):  
A. Spiacci ◽  
T. de Oliveira Sergio ◽  
G.S.F. da Silva ◽  
M.L. Glass ◽  
L.C. Schenberg ◽  
...  
Keyword(s):  
Acute Hypoxia ◽  
Periaqueductal Gray ◽  
Dorsal Periaqueductal Gray ◽  
Defensive Behaviors

Defensive behaviors evoked from the ventrolateral periaqueductal gray of the rat: Comparison of opioid and GABA disinhibition

2005 ◽  
Vol 164 (1) ◽  
pp. 61-66 ◽  
Author(s):  
Michael M. Morgan ◽  
Cecilea C. Clayton
Keyword(s):  
Periaqueductal Gray ◽  
Defensive Behaviors

scholarly journals Dorsal premammillary projection to periaqueductal gray controls escape vigor from innate and conditioned threats

2021 ◽  
Author(s):  
Weisheng Wang ◽  
Peter J Schuette ◽  
Mimi Q La-Vu ◽  
Brooke C Tobias ◽  
Marta Ceko ◽  
...  
Keyword(s):  
Periaqueductal Gray ◽  
Fmri Data ◽  
Central Node ◽  
Defensive Behaviors ◽  
Increased Activity ◽  
Ensemble Activity ◽  
Escape Speed

Escape from threats has paramount importance for survival. However, it is unknown if a single circuit controls escape from innate and conditioned threats. The hypothalamic dorsal premammillary nucleus (PMd) may control escape, as it is activated by escape-inducing threats and projects to the region most implicated in flight, the dorsolateral periaqueductal gray (dlPAG). We show that in mice cholecystokinin (cck)-expressing PMd cells are activated during escape, but not other defensive behaviors. PMd-cck ensemble activity can also predict future escape. Furthermore, PMd inhibition decreases escape speed from both innate and conditioned threats. Inhibition of the PMd-cck projection to the dlPAG also decreased escape speed. Lastly, human fMRI data show that a posterior hypothalamic-to-dlPAG pathway increased activity during exposure to aversive images, indicating that a similar pathway may possibly have a related role in humans. Our data identify the PMd as a central node of the escape network.

Organization of single components of defensive behaviors within distinct columns of periaqueductal gray matter of the rat: role of N-METHYL-d-aspartic acid glutamate receptors

Neuroscience ◽  
2004 ◽  
Vol 125 (1) ◽  
pp. 71-89 ◽  
Author(s):  
A.S. Bittencourt ◽  
A.P. Carobrez ◽  
L.P. Zamprogno ◽  
S. Tufik ◽  
L.C. Schenberg
Keyword(s):  
Glutamate Receptors ◽  
Aspartic Acid ◽  
Gray Matter ◽  
Periaqueductal Gray ◽  
Periaqueductal Gray Matter ◽  
Defensive Behaviors

l-type calcium channels selectively control the defensive behaviors induced by electrical stimulation of dorsal periaqueductal gray and overlying collicular layers

2000 ◽  
Vol 111 (1-2) ◽  
pp. 175-185 ◽  
Author(s):  
Luiz Carlos Schenberg ◽  
Leonardo Pimentel de Almeida Marçal ◽  
Fabiana Seeberger ◽  
Maria Rufina de Barros ◽  
Eliana Cristina Murari Sudré
Keyword(s):  
Electrical Stimulation ◽  
Calcium Channels ◽  
Periaqueductal Gray ◽  
Dorsal Periaqueductal Gray ◽  
Defensive Behaviors ◽  
Stimulation Of

Activation of dorsal periaqueductal gray by glycine produces long lasting hyponociception in rats without overt defensive behaviors

Life Sciences ◽  
2008 ◽  
Vol 83 (3-4) ◽  
pp. 118-121 ◽  
Author(s):  
M.A. Martins ◽  
A.P. Carobrez ◽  
C.R. Tonussi
Keyword(s):  
Periaqueductal Gray ◽  
Dorsal Periaqueductal Gray ◽  
Defensive Behaviors

Characterization of pretentorial periaqueductal gray matter neurons mediating intraspecific defensive behaviors in the rat by microinjections of kainic acid

1989 ◽  
Vol 486 (1) ◽  
pp. 121-132 ◽  
Author(s):  
Antoine Depaulis ◽  
Richard Bandler ◽  
Marguerite Vergnes
Keyword(s):  
Kainic Acid ◽  
Gray Matter ◽  
Periaqueductal Gray ◽  
Periaqueductal Gray Matter ◽  
Defensive Behaviors

Lack of interaction between NMDA and cholecystokinin-2 receptor-mediated neurotransmission in the dorsolateral periaqueductal gray in the regulation of rat defensive behaviors

Life Sciences ◽  
2006 ◽  
Vol 79 (23) ◽  
pp. 2238-2244 ◽  
Author(s):  
L.J. Bertoglio ◽  
F.S. Guimarães ◽  
H. Zangrossi
Keyword(s):  
Periaqueductal Gray ◽  
Defensive Behaviors

scholarly journals Induction of flight via midbrain projections to the cuneiform nucleus

2021 ◽  
Author(s):  
Emmy F Tsang ◽  
Camilla Orlandini ◽  
Rahul Sureka ◽  
Alvaro H Crevenna ◽  
Emerald Perlas ◽  
...  
Keyword(s):  
Escape Behavior ◽  
Periaqueductal Gray ◽  
Flight Behavior ◽  
Optogenetic Stimulation ◽  
Dorsal Periaqueductal Gray ◽  
Defensive Behaviors ◽  
Cuneiform Nucleus ◽  
Midbrain Structure

The dorsal periaqueductal gray is a midbrain structure implicated in the control of defensive behaviors and the processing of painful stimuli. Electrical stimulation or optogenetic activation of excitatory neurons in dorsal periaqueductal gray results in freezing or flight behavior at low or high intensity, respectively. However, the output structures that mediate these defensive behaviors remain unconfirmed. Here we carried out a targeted classification of neuron types in dorsal periaqueductal gray using multiplex in situ sequencing and then applied cell-type and projection-specific optogenetic stimulation to identify projections from dorsal periaqueductal gray to the cuneiform nucleus that promoted goal-directed flight behavior. These data confirmed that descending outputs from dorsal periaqueductal gray serve as a trigger for directed escape behavior.

scholarly journals Fine-tuning of defensive behaviors in the dorsal periaqueductal gray by atypical neurotransmitters

2012 ◽  
Vol 45 (4) ◽  
pp. 357-365 ◽  
Author(s):  
M.V. Fogaça ◽  
S.F. Lisboa ◽  
D.C. Aguiar ◽  
F.A. Moreira ◽  
F.V. Gomes ◽  
...  
Keyword(s):  
Periaqueductal Gray ◽  
Fine Tuning ◽  
Dorsal Periaqueductal Gray ◽  
Defensive Behaviors
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