scholarly journals Assessment of ventral tegmental area-projecting GABAergic neurons from the bed nucleus of the stria terminalis in modulating binge-like ethanol intake

2018 ◽  
Vol 48 (11) ◽  
pp. 3335-3343 ◽  
Author(s):  
Michel A. Companion ◽  
Todd E. Thiele
Keyword(s):  
Ventral Tegmental Area ◽  
Gabaergic Neurons ◽  
Ethanol Intake ◽  
Stria Terminalis ◽  
Bed Nucleus ◽  
Ventral Tegmental

GABAergic neurons in the ventral tegmental area receive dual GABA/enkephalin-mediated inhibitory inputs from the bed nucleus of the stria terminalis

2014 ◽  
Vol 39 (11) ◽  
pp. 1796-1809 ◽  
Author(s):  
Takehiro Kudo ◽  
Kohtarou Konno ◽  
Motokazu Uchigashima ◽  
Yuchio Yanagawa ◽  
Ichiro Sora ◽  
...  
Keyword(s):  
Ventral Tegmental Area ◽  
Gabaergic Neurons ◽  
Stria Terminalis ◽  
Bed Nucleus ◽  
Ventral Tegmental

Neurochemical characterization of neurons in the bed nucleus of the stria terminalis projecting to the ventral tegmental area

2011 ◽  
Vol 71 ◽  
pp. e322
Author(s):  
Takehiro Kudo ◽  
Motokazu Uchigashima ◽  
Taisuke Miyazaki ◽  
Miwako Yamasaki ◽  
Masabumi Minami ◽  
...  
Keyword(s):  
Ventral Tegmental Area ◽  
Stria Terminalis ◽  
Bed Nucleus ◽  
Ventral Tegmental

scholarly journals Role of the bed nucleus of the stria terminalis in the control of ventral tegmental area dopamine neurons

2009 ◽  
Vol 33 (8) ◽  
pp. 1336-1346 ◽  
Author(s):  
Marion Jalabert ◽  
Gary Aston-Jones ◽  
Etienne Herzog ◽  
Olivier Manzoni ◽  
François Georges
Keyword(s):  
Ventral Tegmental Area ◽  
Dopamine Neurons ◽  
Stria Terminalis ◽  
Bed Nucleus ◽  
Ventral Tegmental

scholarly journals A midbrain dynorphin circuit promotes threat generalization

2020 ◽  
Author(s):  
Lizz Fellinger ◽  
Yong S. Jo ◽  
Avery C. Hunker ◽  
Marta E. Soden ◽  
Larry S. Zweifel
Keyword(s):  
Ventral Tegmental Area ◽  
Opioid Receptor ◽  
Dorsal Raphe Nucleus ◽  
Kappa Opioid Receptor ◽  
Raphe Nucleus ◽  
Stria Terminalis ◽  
Kappa Opioid ◽  
Bed Nucleus ◽  
Ventral Tegmental ◽  
Threat Stimuli

SummaryDiscrimination between predictive and non-predictive threat stimuli decrease as threat intensity increases. The central mechanisms that mediate the transition from discriminatory to generalized threat responding remain poorly resolved. Here, we identify the stress- and dysphoria-associated kappa opioid receptor (KOR) and its ligand dynorphin (Dyn), acting in the ventral tegmental area (VTA), as a key substrate for regulating threat generalization. We identified several dynorphinergic inputs to the VTA and demonstrate that projections from the bed nucleus of the stria terminalis (BNST) and dorsal raphe nucleus (DRN) both contribute to anxiety-like behavior but differentially affect threat generalization. These data demonstrate that conditioned threat discrimination has an inverted ‘U’ relationship with threat intensity and establish a role for KOR/Dyn signaling in the midbrain for promoting threat generalization.

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