Bed Nucleus of the Stria Terminalis–Derived Corticotropin-Releasing Factor Controls Binge Alcohol Drinking Via Interacting With Corticotropin-Releasing Factor Receptors 1 and 2 in the Ventral Tegmental Area

2017 ◽  
Vol 81 (11) ◽  
pp. 905-906 ◽  
Author(s):  
Leszek Kaczmarek
Keyword(s):  
Ventral Tegmental Area ◽  
Alcohol Drinking ◽  
Corticotropin Releasing Factor ◽  
Stria Terminalis ◽  
Bed Nucleus ◽  
Ventral Tegmental

Neurochemical characterization of neurons in the bed nucleus of the stria terminalis projecting to the ventral tegmental area

2011 ◽  
Vol 71 ◽  
pp. e322
Author(s):  
Takehiro Kudo ◽  
Motokazu Uchigashima ◽  
Taisuke Miyazaki ◽  
Miwako Yamasaki ◽  
Masabumi Minami ◽  
...  
Keyword(s):  
Ventral Tegmental Area ◽  
Stria Terminalis ◽  
Bed Nucleus ◽  
Ventral Tegmental

GABAergic neurons in the ventral tegmental area receive dual GABA/enkephalin-mediated inhibitory inputs from the bed nucleus of the stria terminalis

2014 ◽  
Vol 39 (11) ◽  
pp. 1796-1809 ◽  
Author(s):  
Takehiro Kudo ◽  
Kohtarou Konno ◽  
Motokazu Uchigashima ◽  
Yuchio Yanagawa ◽  
Ichiro Sora ◽  
...  
Keyword(s):  
Ventral Tegmental Area ◽  
Gabaergic Neurons ◽  
Stria Terminalis ◽  
Bed Nucleus ◽  
Ventral Tegmental

scholarly journals Role of the bed nucleus of the stria terminalis in the control of ventral tegmental area dopamine neurons

2009 ◽  
Vol 33 (8) ◽  
pp. 1336-1346 ◽  
Author(s):  
Marion Jalabert ◽  
Gary Aston-Jones ◽  
Etienne Herzog ◽  
Olivier Manzoni ◽  
François Georges
Keyword(s):  
Ventral Tegmental Area ◽  
Dopamine Neurons ◽  
Stria Terminalis ◽  
Bed Nucleus ◽  
Ventral Tegmental

scholarly journals The paraventricular thalamus provides a polysynaptic brake on limbic CRF neurons to sex-dependently blunt binge alcohol drinking and avoidance behavior in mice

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Olivia B. Levine ◽  
Mary Jane Skelly ◽  
John D. Miller ◽  
Jean K. Rivera-Irizarry ◽  
Sydney A. Rowson ◽  
...  
Keyword(s):  
Synaptic Input ◽  
Alcohol Drinking ◽  
Avoidance Behavior ◽  
Corticotropin Releasing Factor ◽  
Stria Terminalis ◽  
Bed Nucleus ◽  
Synaptic Excitation ◽  
Per Se ◽  
Paraventricular Thalamus ◽  
Crf Neurons

AbstractBed nucleus of the stria terminalis (BNST) neurons that synthesize corticotropin-releasing factor (CRF) drive binge alcohol drinking and anxiety. Here, we found that female C57BL/6J mice binge drink more than males and have greater basal BNSTCRF neuron excitability and synaptic excitation. We identified a dense VGLUT2 + synaptic input from the paraventricular thalamus (PVT) that releases glutamate directly onto BNSTCRF neurons but also engages a large BNST interneuron population to ultimately inhibit BNSTCRF neurons, and this polysynaptic PVTVGLUT2-BNSTCRF circuit is more robust in females than males. Chemogenetic inhibition of the PVTBNST projection promoted binge alcohol drinking only in female mice, while activation reduced avoidance behavior in both sexes. Lastly, repeated binge drinking produced a female-like phenotype in the male PVT-BNSTCRF excitatory synapse without altering the function of PVTBNST neurons per se. Our data describe a complex, feedforward inhibitory PVTVGLUT2-BNSTCRF circuit that is sex-dependent in its function, behavioral roles, and alcohol-induced plasticity.

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