Small loci of astroglial glutamine synthetase deficiency in the postnatal brain cause epileptic seizures and impaired functional connectivity

Epilepsia ◽  
2021 ◽  
Author(s):  
Maxwell G. Farina ◽  
Mani Ratnesh S. Sandhu ◽  
Maxime Parent ◽  
Basavaraju G. Sanganahalli ◽  
Matthew Derbin ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Glutamine Synthetase ◽  
Epileptic Seizures ◽  
Postnatal Brain ◽  
Synthetase Deficiency

Functional connectivity of dissociation in patients with psychogenic non-epileptic seizures

2011 ◽  
Vol 83 (3) ◽  
pp. 239-247 ◽  
Author(s):  
Sylvie J M van der Kruijs ◽  
Nynke M G Bodde ◽  
Maarten J Vaessen ◽  
Richard H C Lazeron ◽  
Kristl Vonck ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Epileptic Seizures

scholarly journals Altered Functional Connectivity after Epileptic Seizure Revealed by Scalp EEG

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Yi Liang ◽  
Chunli Chen ◽  
Fali Li ◽  
Dezhong Yao ◽  
Peng Xu ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Brain Activity ◽  
Epileptic Seizures ◽  
Local Area ◽  
Brain Network ◽  
Fuzzy Entropy ◽  
Clustering Coefficient ◽  
Characteristic Path Length ◽  
Functional Brain Network ◽  
Before And After

Epileptic seizures are considered to be a brain network dysfunction, and chronic recurrent seizures can cause severe brain damage. However, the functional brain network underlying recurrent epileptic seizures is still left unveiled. This study is aimed at exploring the differences in a related brain activity before and after chronic repetitive seizures by investigating the power spectral density (PSD), fuzzy entropy, and functional connectivity in epileptic patients. The PSD analysis revealed differences between the two states at local area, showing postseizure energy accumulation. Besides, the fuzzy entropies of preseizure in the frontal, central, and temporal regions are higher than that of postseizure. Additionally, attenuated long-range connectivity and enhanced local connectivity were also found. Moreover, significant correlations were found between network metrics (i.e., characteristic path length and clustering coefficient) and individual seizure number. The PSD, fuzzy entropy, and network analysis may indicate that the brain is gradually impaired along with the occurrence of epilepsy, and the accumulated effect of brain impairment is observed in individuals with consecutive epileptic bursts. The findings of this study may provide helpful insights into understanding the network mechanism underlying chronic recurrent epilepsy.

Abnormal functional connectivity density in psychogenic non-epileptic seizures

2014 ◽  
Vol 108 (7) ◽  
pp. 1184-1194 ◽  
Author(s):  
Jurong Ding ◽  
Dongmei An ◽  
Wei Liao ◽  
Guorong Wu ◽  
Qiang Xu ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Epileptic Seizures ◽  
Functional Connectivity Density

scholarly journals Altered regional activity and inter-regional functional connectivity in psychogenic non-epileptic seizures

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Rong Li ◽  
Yibo Li ◽  
Dongmei An ◽  
Qiyong Gong ◽  
Dong Zhou ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Epileptic Seizures ◽  
Regional Activity

Inborn error of amino acid synthesis: Human glutamine synthetase deficiency

2006 ◽  
Vol 29 (2-3) ◽  
pp. 352-358 ◽  
Author(s):  
Johannes Häberle ◽  
Boris Görg ◽  
Annick Toutain ◽  
Frank Rutsch ◽  
Jean-François Benoist ◽  
...  
Keyword(s):  
Amino Acid ◽  
Glutamine Synthetase ◽  
Inborn Error ◽  
Acid Synthesis ◽  
Amino Acid Synthesis ◽  
Synthetase Deficiency

scholarly journals Impaired novelty acquisition and synaptic plasticity in congenital hyperammonemia caused by hepatic glutamine synthetase deficiency

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Aisa N. Chepkova ◽  
Olga A. Sergeeva ◽  
Boris Görg ◽  
Helmut L. Haas ◽  
Nikolaj Klöcker ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Glutamine Synthetase ◽  
Synthetase Deficiency

Glutamine synthetase deficiency

2020 ◽  
pp. 259-262
Author(s):  
William L. Nyhan ◽  
Georg F. Hoffmann ◽  
Aida I. Al-Aqeel ◽  
Bruce A. Barshop
Keyword(s):  
Glutamine Synthetase ◽  
Synthetase Deficiency

Aberrant gamma band cortical sources and functional connectivity in adolescents with psychogenic non-epileptic seizures: A preliminary report

2017 ◽  
Vol 247 ◽  
pp. 51-54 ◽  
Author(s):  
Shreekantiah Umesh ◽  
Sai Krishna Tikka ◽  
Nishant Goyal ◽  
Vinod Kumar Sinha ◽  
Shamshul Haque Nizamie
Keyword(s):  
Functional Connectivity ◽  
Preliminary Report ◽  
Epileptic Seizures ◽  
Gamma Band ◽  
Cortical Sources
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