Hibiscus sabdariffaincreases hydroxocobalamin oral bioavailability and clinical efficacy in vitamin B12deficiency with neurological symptoms

2016 ◽  
Vol 30 (6) ◽  
pp. 568-576
Author(s):  
Zouhayr Souirti ◽  
Mouna Loukili ◽  
Imar D. Soudy ◽  
Kaies Rtibi ◽  
Aslihan Özel ◽  
...  
Keyword(s):  
Clinical Efficacy ◽  
Oral Bioavailability ◽  
Neurological Symptoms

Discovery of Ritonavir, a Potent Inhibitor of HIV Protease with High Oral Bioavailability and Clinical Efficacy

1998 ◽  
Vol 41 (4) ◽  
pp. 602-617 ◽  
Author(s):  
Dale J. Kempf ◽  
Hing L. Sham ◽  
Kennan C. Marsh ◽  
Charles A. Flentge ◽  
David Betebenner ◽  
...  
Keyword(s):  
Clinical Efficacy ◽  
Oral Bioavailability ◽  
Potent Inhibitor ◽  
Hiv Protease

scholarly journals Pharmacokinetics of Orally Administered GS-441524 in Dogs

2021 ◽  
Author(s):  
Victoria C. Yan ◽  
Sunada Khadka ◽  
Kenisha Arthur ◽  
Cong-Dat Pham ◽  
Matthew J. Yan ◽  
...  
Keyword(s):  
Clinical Efficacy ◽  
Oral Bioavailability ◽  
Plasma Concentrations ◽  
Beagle Dogs ◽  
Oral Agent ◽  
Data Support

AbstractDespite being FDA-approved for COVID-19, the clinical efficacy of remdesivir (Veklury®) remains contentious. We previously described the pharmacokinetic, pharmacodynamic and toxicological rationales on the greater suitability of its parent nucleoside, GS-441524, for COVID-19 treatment. Here, we assess the oral bioavailability of GS-441524 in beagle dogs and show that plasma concentrations approximately 24-fold higher than the EC50 against SARS-CoV-2 are easily and safely sustained. These data support translation of GS-441524 as an oral agent for COVID-19.

The incidence of transient neurological symptoms after spinal anaesthesia with lidocaine compared to prilocaine

Anaesthesia ◽  
2000 ◽  
Vol 55 (10) ◽  
pp. 1020-1024 ◽  
Author(s):  
K. De Weert ◽  
M. Traksel ◽  
M. Gielen ◽  
R. Slappendel ◽  
E. Weber ◽  
...  
Keyword(s):  
Spinal Anaesthesia ◽  
Neurological Symptoms

Clinical efficacy of specific immunotherapy to cat dander: a double-blind placebo-controlled trial

1997 ◽  
Vol 27 (8) ◽  
pp. 860-867 ◽  
Author(s):  
V.A. VARNEY ◽  
J. EDWARDS ◽  
K. TABBAH ◽  
H. BREWSTER ◽  
G. MAVROLEON ◽  
...  
Keyword(s):  
Clinical Efficacy ◽  
Specific Immunotherapy ◽  
Controlled Trial ◽  
Double Blind ◽  
Double Blind Placebo

Enhancement of oral bioavailability of pentoxifylline by solid lipid nanoparticles

2009 ◽  
Vol 00 (00) ◽  
pp. 090820062440031-9 ◽  
Author(s):  
Jaleh Varshosaz ◽  
Mohsen Minayian ◽  
Elaheh Moazen
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Oral Bioavailability ◽  
Lipid Nanoparticles ◽  
Solid Lipid
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