scholarly journals Respiratory Complex I dysfunction in cancer: from a maze of cellular adaptive responses to potential therapeutic strategies

FEBS Journal ◽  
2021 ◽  
Author(s):  
Manuela Sollazzo ◽  
Monica De Luise ◽  
Silvia Lemma ◽  
Licia Bressi ◽  
Maria Iorio ◽  
...  
Keyword(s):  
Complex I ◽  
Therapeutic Strategies ◽  
Adaptive Responses ◽  
Respiratory Complex ◽  
Respiratory Complex I

scholarly journals Structural and Energetic Affinity of Annocatacin B with ND1 Subunit of the Human Mitochondrial Respiratory Complex I as a Potential Inhibitor: An In Silico Comparison Study with the Known Inhibitor Rotenone

Polymers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1840
Author(s):  
Camilo Febres-Molina ◽  
Jorge A. Aguilar-Pineda ◽  
Pamela L. Gamero-Begazo ◽  
Haruna L. Barazorda-Ccahuana ◽  
Diego E. Valencia ◽  
...  
Keyword(s):  
Free Energy ◽  
In Silico ◽  
Complex I ◽  
Binding Free Energy ◽  
Biological Activities ◽  
Experimental Studies ◽  
Respiratory Complex ◽  
Mitochondrial Respiratory Complex ◽  
Respiratory Complex I ◽  
Mitochondrial Respiratory

ND1 subunit possesses the majority of the inhibitor binding domain of the human mitochondrial respiratory complex I. This is an attractive target for the search for new inhibitors that seek mitochondrial dysfunction. It is known, from in vitro experiments, that some metabolites from Annona muricata called acetogenins have important biological activities, such as anticancer, antiparasitic, and insecticide. Previous studies propose an inhibitory activity of bovine mitochondrial respiratory complex I by bis-tetrahydrofurans acetogenins such as annocatacin B, however, there are few studies on its inhibitory effect on human mitochondrial respiratory complex I. In this work, we evaluate the in silico molecular and energetic affinity of the annocatacin B molecule with the human ND1 subunit in order to elucidate its potential capacity to be a good inhibitor of this subunit. For this purpose, quantum mechanical optimizations, molecular dynamics simulations and the molecular mechanics/Poisson–Boltzmann surface area (MM/PBSA) analysis were performed. As a control to compare our outcomes, the molecule rotenone, which is a known mitochondrial respiratory complex I inhibitor, was chosen. Our results show that annocatacin B has a greater affinity for the ND1 structure, its size and folding were probably the main characteristics that contributed to stabilize the molecular complex. Furthermore, the MM/PBSA calculations showed a 35% stronger binding free energy compared to the rotenone complex. Detailed analysis of the binding free energy shows that the aliphatic chains of annocatacin B play a key role in molecular coupling by distributing favorable interactions throughout the major part of the ND1 structure. These results are consistent with experimental studies that mention that acetogenins may be good inhibitors of the mitochondrial respiratory complex I.

scholarly journals A salvage pathway maintains highly functional respiratory complex I

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Karolina Szczepanowska ◽  
Katharina Senft ◽  
Juliana Heidler ◽  
Marija Herholz ◽  
Alexandra Kukat ◽  
...  
Keyword(s):  
Complex I ◽  
Salvage Pathway ◽  
Respiratory Complex ◽  
Respiratory Complex I

Molecular Gene Therapy: Overexpression of the Alternative NADH Dehydrogenase NDI1 Restores Overall Physiology in a Fungal Model of Respiratory Complex I Deficiency

2010 ◽  
Vol 399 (1) ◽  
pp. 31-40 ◽  
Author(s):  
Marc F.P.M. Maas ◽  
Carole H. Sellem ◽  
Frank Krause ◽  
Norbert A. Dencher ◽  
Annie Sainsard-Chanet
Keyword(s):  
Gene Therapy ◽  
Complex I ◽  
Nadh Dehydrogenase ◽  
Respiratory Complex ◽  
Complex I Deficiency ◽  
Respiratory Complex I

scholarly journals Molecular basis of Leigh-like syndrome in respiratory complex I

2014 ◽  
Vol 1837 ◽  
pp. e43
Author(s):  
Emmanuel Gnandt ◽  
Karoline Aierstock ◽  
Klaudia Morina ◽  
Manuel Moser ◽  
Lukas Denkhaus ◽  
...  
Keyword(s):  
Molecular Basis ◽  
Complex I ◽  
Respiratory Complex ◽  
Respiratory Complex I

Targeting respiratory complex I to prevent the Warburg effect

2015 ◽  
Vol 63 ◽  
pp. 41-45 ◽  
Author(s):  
Renaud Vatrinet ◽  
Luisa Iommarini ◽  
Ivana Kurelac ◽  
Monica De Luise ◽  
Giuseppe Gasparre ◽  
...  
Keyword(s):  
Warburg Effect ◽  
Complex I ◽  
Respiratory Complex ◽  
Respiratory Complex I ◽  
The Warburg Effect
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