scholarly journals Role of geochemical protoenzymes (geozymes) in primordial metabolism: Specific abiotic hydride transfer by metals to the biological redox cofactor NAD +

FEBS Journal ◽  
2021 ◽  
Author(s):  
Delfina P. Henriques Pereira ◽  
Jana Leethaus ◽  
Tugce Beyazay ◽  
Andrey do Nascimento Vieira ◽  
Karl Kleinermanns ◽  
...  
Keyword(s):  
Hydride Transfer

scholarly journals Experimental and Computational Studies Delineate the Role of Asparagine 177 in Hydride Transfer forE. coliThymidylate Synthase

ACS Catalysis ◽  
2018 ◽  
Vol 8 (11) ◽  
pp. 10241-10253 ◽  
Author(s):  
Ilya Gurevic ◽  
Zahidul Islam ◽  
Katarzyna Świderek ◽  
Kai Trepka ◽  
Ananda K. Ghosh ◽  
...  
Keyword(s):  
Hydride Transfer ◽  
Computational Studies

Formation of .eta.3-cyclooctenyl complexes from hydride transfer reactions in hydrido(cycloocta-1,5-diene)tris(ligand)ruthenium(II) cations: the dominant role of steric effects

1984 ◽  
Vol 3 (10) ◽  
pp. 1485-1491 ◽  
Author(s):  
Terence V. Ashworth ◽  
Anthony A. Chalmers ◽  
Elsie Meintjies ◽  
Hester E. Oosthuizen ◽  
Eric Singleton
Keyword(s):  
Dominant Role ◽  
Hydride Transfer ◽  
Transfer Reactions ◽  
Steric Effects ◽  
Hydride Transfer Reactions

Role of Glu312 in Binding and Positioning of the Substrate for the Hydride Transfer Reaction in Choline Oxidase†,‡

Biochemistry ◽  
2008 ◽  
Vol 47 (1) ◽  
pp. 243-256 ◽  
Author(s):  
Osbourne Quaye ◽  
George T. Lountos ◽  
Fan ◽  
Allen M. Orville ◽  
Giovanni Gadda
Keyword(s):  
Transfer Reaction ◽  
Hydride Transfer ◽  
Choline Oxidase ◽  
Hydride Transfer Reaction

Structural basis for the catalytic mechanism of homoserine dehydrogenase

2015 ◽  
Vol 71 (5) ◽  
pp. 1216-1225 ◽  
Author(s):  
Vikas Navratna ◽  
Govardhan Reddy ◽  
Balasubramanian Gopal
Keyword(s):  
Reaction Mechanism ◽  
Catalytic Mechanism ◽  
Mutational Analysis ◽  
Hydride Transfer ◽  
Structural Basis ◽  
Homoserine Dehydrogenase ◽  
Transfer Step ◽  
Conserved Water Molecules ◽  
Acid Pathway

Homoserine dehydrogenase (HSD) is an oxidoreductase in the aspartic acid pathway. This enzyme coordinates a critical branch point of the metabolic pathway that leads to the synthesis of bacterial cell-wall components such as L-lysine andm-DAP in addition to other amino acids such as L-threonine, L-methionine and L-isoleucine. Here, a structural rationale for the hydride-transfer step in the reaction mechanism of HSD is reported. The structure ofStaphylococcus aureusHSD was determined at different pH conditions to understand the basis for the enhanced enzymatic activity at basic pH. An analysis of the crystal structure revealed that Lys105, which is located at the interface of the catalytic and cofactor-binding sites, could mediate the hydride-transfer step of the reaction mechanism. The role of Lys105 was subsequently confirmed by mutational analysis. Put together, these studies reveal the role of conserved water molecules and a lysine residue in hydride transfer between the substrate and the cofactor.

scholarly journals Probing the Role of Dynamics in Hydride Transfer Catalyzed by Lactate Dehydrogenase

2008 ◽  
Vol 95 (4) ◽  
pp. 1974-1984 ◽  
Author(s):  
Nickolay Zhadin ◽  
Miriam Gulotta ◽  
Robert Callender
Keyword(s):  
Lactate Dehydrogenase ◽  
Hydride Transfer

Theoretical Study of the Mechanism of the Hydride Transfer between Ferredoxin–NADP+ Reductase and NADP+: The Role of Tyr303

2012 ◽  
Vol 134 (50) ◽  
pp. 20544-20553 ◽  
Author(s):  
Isaias Lans ◽  
Milagros Medina ◽  
Edina Rosta ◽  
Gerhard Hummer ◽  
Mireia Garcia-Viloca ◽  
...  
Keyword(s):  
Theoretical Study ◽  
Hydride Transfer
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