Magnetic resonance imaging and ultrasound evaluation of “healthy” joints in young subjects with severe haemophilia A

Haemophilia ◽  
2013 ◽  
Vol 19 (3) ◽  
pp. e167-e173 ◽  
Author(s):  
M. N. D. Di Minno ◽  
S. Iervolino ◽  
E. Soscia ◽  
A. Tosetto ◽  
A. Coppola ◽  
...  
2017 ◽  
Vol 30 (05) ◽  
pp. 371-376
Author(s):  
Mathieu Manassero ◽  
Jean-Laurent Thibaud ◽  
Edouard Reyes-Gomez ◽  
Véronique Viateau ◽  
Adeline Decambron

Summary Objectives: This case report describes for the first time a bone haemophilic pseudotumour in a dog. Case description: A seven-month-old German Shepherd male dog was presented with the complaint of a forelimb weight-bearing lameness with major swelling that expanded dramatically after fine needle aspiration. Radiographs showed a large, well-defined ulnar diaphyseal cystic-like osteolytic lesion. Based on prolonged activated partial thromboplastin time (aPTT) and low factor VIII activity, haemophilia A was diagnosed. Bone scintigraphy, computed tomography, magnetic resonance imaging, and histological findings definitely ruled out malignant neoplasia or inflammation and strongly supported a bone haemophilic pseudotumour over an aneurysmal bone cyst. Segmental ulnar resection and replacement by a polymethylmethacrylate spacer combined with perioperative bleeding management resulted in a successful outcome. Discussion: This case provided evidence that a bone haemophilic pseudotumour may be the sole presenting clinical sign of haemophilia A in dogs. Early diagnosis, based on history and magnetic resonance imaging findings, is imperative for prompt treatment leading to successful outcome. It is challenging as fine needle aspiration or biopsy is contraindicated. As described in humans, surgical excision of the lesion combined with management of severe postoperative bleeding was associated with successful outcome in the present case. Clinical significance: A bone haemophilic pseudotumour should be considered in the differential diagnosis of expanding mass associated with osteolysis, especially in young male dogs. Perioperative monitoring of the bleeding disorder and subsequent FVIII replacement therapy was of paramount importance in the present case.


2017 ◽  
Vol 21 (1) ◽  
Author(s):  
Chantelle Van Niekerk ◽  
Barbara Van Dyk

Background: Syndesmosis injuries are often more serious than an injury to the lateral ligament complex of the ankle, with double the recovery time, chronic discomfort and joint instability. Although magnetic resonance imaging (MRI) is considered as the best imaging modality to assess the integrity of the syndesmotic ligamentous complex and clear space, a dynamic ultrasound evaluation may provide an alternative imaging option worthy of exploring.Aim: The aim of this article is to compare the sensitivity and specificity of musculoskeletal ultrasound and MRI, in the diagnosis of syndesmosis pathology, with surgical findings as the reference point.Method: MRI was performed on 114 participants presenting with pain over the lateral aspect of the ankle after injury. This was followed by a dynamic ultrasound examination during which the anterior tibiofibular ligament (ATiFL) was assessed for continuity, contour and haematoma. The tibiofibular clear space was measured with the ankle in a neutral position, followed by internal and external rotation.Results: The Fisher’s exact test was used to determine non-random associations between variables and compute statistical significance (p < 0.05). Ultrasound achieved a sensitivity of 86.3%, specificity of 97% with a false-positive rate of 3%. The sensitivity of MRI is similar to that of ultrasound (86%) with a specificity of 100%.Conclusion: Although both imaging tests performed very well, MRI was slightly better at excluding pathology while both tests performed equally in demonstrating pathology. As a simple, inexpensive and reproducible test, dynamic ultrasound can thus be considered as an alternative to MRI in acute ankle pathology.


Urology ◽  
1998 ◽  
Vol 51 (6) ◽  
pp. 1018-1021 ◽  
Author(s):  
Alexander D Serra ◽  
Hedvig Hricak ◽  
Fergus V Coakley ◽  
Bohyun Kim ◽  
Adams Dudley ◽  
...  

2013 ◽  
Vol 132 (4) ◽  
pp. 498e-509e ◽  
Author(s):  
Valeria Fiaschetti ◽  
Chiara A. Pistolese ◽  
Maria Fornari ◽  
Valeria Liberto ◽  
Valentina Cama ◽  
...  

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