Efficacy of eradication therapy in Helicobacter pylori ‐negative gastric mucosa‐associated lymphoid tissue lymphoma: A meta‐analysis

Helicobacter ◽  
2021 ◽  
Author(s):  
Kyoungwon Jung ◽  
Do Hoon Kim ◽  
Hyun Il Seo ◽  
Eun Jeong Gong ◽  
Chang Seok Bang
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Lymphoid Tissue ◽  
Meta Analysis ◽  
Eradication Therapy

scholarly journals Eradication Therapy Is Effective for Helicobacter pylori-Negative Gastric Mucosa-Associated Lymphoid Tissue Lymphoma

2012 ◽  
Vol 228 (3) ◽  
pp. 223-227 ◽  
Author(s):  
Naoki Asano ◽  
Katsunori Iijima ◽  
Shiho Terai ◽  
Xiaoyi Jin ◽  
Nobuyuki Ara ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Lymphoid Tissue ◽  
Eradication Therapy

Resistance of t(11;18) positive gastric mucosa-associated lymphoid tissue lymphoma to Helicobacter pylori eradication therapy

The Lancet ◽  
2001 ◽  
Vol 357 (9249) ◽  
pp. 39-40 ◽  
Author(s):  
Hongxiang Liu ◽  
Agnes Ruskon-Fourmestraux ◽  
Anne Lavergne-Slove ◽  
Hongtao Ye ◽  
Thierry Molina ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Lymphoid Tissue ◽  
Eradication Therapy ◽  
Helicobacter Pylori Eradication ◽  
Helicobacter Pylori Eradication Therapy

scholarly journals Prognostic Impact of Helicobacter pylori Infection and Eradication Therapy in Gastric Mucosa-associated Lymphoid Tissue Lymphoma

2010 ◽  
Vol 30 (6) ◽  
pp. 547-553 ◽  
Author(s):  
Sang Hyuk Park ◽  
Hyun-Sook Chi ◽  
Seo-Jin Park ◽  
Seongsoo Jang ◽  
Chan-Jeoung Park ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Lymphoid Tissue ◽  
Eradication Therapy ◽  
Helicobacter Pylori Infection ◽  
Prognostic Impact

scholarly journals Outcome of Radiotherapy for Gastric Mucosa-Associated Lymphoid Tissue Lymphoma Refractory to Helicobacter Pylori Eradication Therapy

2006 ◽  
Vol 45 (6) ◽  
pp. 405-409 ◽  
Author(s):  
Mitsushige Sugimoto ◽  
Masayoshi Kajimura ◽  
Naohito Shirai ◽  
Takahisa Furuta ◽  
Shigeru Kanaoka ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Lymphoid Tissue ◽  
Eradication Therapy ◽  
Helicobacter Pylori Eradication ◽  
Helicobacter Pylori Eradication Therapy

scholarly journals Helicobacter pylori cagA Status and Gastric Mucosa-associated Lymphoid Tissue Lymphoma: a Systematic Review and Meta-analysis

2021 ◽  
Author(s):  
Mohsen Karbaalei ◽  
Amirhossein Sahebkar ◽  
Yoshio Yamaoka ◽  
Masoud Keikha
Keyword(s):  
Systematic Review ◽  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Lymphoid Tissue ◽  
Meta Analysis ◽  
Publication Date ◽  
Inverse Association ◽  
High Grade ◽  
H Pylori

Abstract Background: Recent studies have investigated the role of Helicobacter pylori infection in the development of gastric mucosa-associated lymphoid tissue (MALT) lymphoma. It is estimated that approximately 0.1% of people infected with H. pylori develop gastric MALT. However, the role of the CagA antigen, the highest causative agent of H. pylori, in increasing the risk of gastric MALT remains unclear and controversial. A systematic review and meta-analysis were conducted to evaluate the effect of cagA status on the development of gastric MALT.Methods: All articles evaluating the status of the cagA gene in the development of gastric MALT were collected using systematic searches in online databases, including PubMed, Scopus, Embase, and Google Scholar, regardless of publication date. The association between cagA and gastric MALT was assessed using the odds ratio (OR) summary. In addition, a random-effects model was used in cases with significant heterogeneity.Results: A total of 10 studies met our inclusion criteria, among which 1,860 patients participated. We observed a meaningful association between cagA status and gastric MALT, especially in Western countries (OR: 1.30; 0.90–1.87 with 95% CIs). However, the heterogeneity was significant; therefore, the results should be interpreted with caution. Surprisingly, a strong positive association was observed between cagA status and high-grade lymphomas (OR: 6.43; 2.45–16.84 with 95% CIs). In addition, no study has evaluated the correlation between cagA and vacA, but we observed an inverse association between vacA and gastric MALT risk (OR: 0.92; 0.57–1.50 with 95% CIs). Conclusion: CagA may not play a significant role in the early stages of gastric MALT, but it can be translocated to B cells and affect the development of high-grade lymphomas.

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