Fibrous hamartoma of infancy with hypertrichosis: the diagnostic challenge of a rare late‐onset case

2020 ◽  
Author(s):  
Madhusmita Sethy ◽  
Biswanath Behera ◽  
Aparna Palit ◽  
Ashish Kumar Nayak ◽  
Siddhartha Dash ◽  
...  
Keyword(s):  
Late Onset ◽  
Diagnostic Challenge ◽  
Fibrous Hamartoma Of Infancy

A diagnostic challenge of late onset adult merosinopathy

2017 ◽  
Vol 27 ◽  
pp. S107-S108
Author(s):  
C. von Landenberg ◽  
K. Kappes-Horn ◽  
M. Stepien-Mering ◽  
J. Reimann
Keyword(s):  
Late Onset ◽  
Diagnostic Challenge

scholarly journals Late onset cystoid macular oedema presents a diagnostic challenge

2014 ◽  
Vol 97 (5) ◽  
pp. 459-462 ◽  
Author(s):  
Leon Nehmad
Keyword(s):  
Macular Oedema ◽  
Late Onset ◽  
Cystoid Macular Oedema ◽  
Diagnostic Challenge

Rapidly progressive course of very late onset multiple sclerosis presenting with Parkinsonism: case report

2010 ◽  
Vol 17 (2) ◽  
pp. 245-249 ◽  
Author(s):  
T Schultheiss ◽  
H Reichmann ◽  
T Ziemssen
Keyword(s):  
Multiple Sclerosis ◽  
Potential Benefit ◽  
Late Onset ◽  
Age Groups ◽  
Treatment Strategies ◽  
Disease Course ◽  
Spastic Paraplegia ◽  
Diagnostic Challenge ◽  
Progressive Course ◽  
Neuroprotective Therapies

Multiple sclerosis mainly affects young adolescents, making late-onset multiple sclerosis a rarity and diagnostic challenge, particularly for cases after age 80 years. We present an 82-year-old patient with multiple sclerosis with very late onset. As well as spastic paraplegia, additional Parkinsonism secondary to demyelination in the basal ganglia was observed in this case. In most publications, spinal cord lesions were more common in late-onset multiple sclerosis which, in contrast, could not be found in our case. Despite different treatment strategies, rapid clinical deterioration and death after about 2 years of disease course occurred. Further discrimination in late-onset multiple sclerosis (50–70 years) and multiple sclerosis with very late onset (above 70 years) might be considered. Future trials to elucidate potential benefit of immunosuppressive (and neuroprotective) therapies in these age groups are mandatory.

scholarly journals Late Onset Systemic Lupus Erythematosus in an Afro-Caribbean Patient: A Diagnostic Challenge

2018 ◽  
Vol 1 (2) ◽  
pp. 84-89
Author(s):  
Barrett-Campbell Odeth ◽  
◽  
James-Goulbourne Tracian ◽  
Shapira Iuliana ◽  
◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Elderly Population ◽  
Late Onset ◽  
The Elderly ◽  
Chronic Illnesses ◽  
Systemic Lupus ◽  
Diagnostic Challenge ◽  
Caribbean Woman ◽  
Onset Systemic Lupus Erythematosus

Systemic Lupus Erythematosus may be missed in the elderly population as the clinical features may resemble more common conditions. Treatment remains a challenge in this group given the co-existing chronic illnesses and drug-related toxicities. Herein, we report a case of a 72-year-old Afro-Caribbean woman diagnosed with systemic lupus erythematosus after having pulmonary and renal manifestations.

Late onset multiple sclerosis (LOMS): A diagnostic challenge

2013 ◽  
Vol 333 ◽  
pp. e413
Author(s):  
B. Miguel ◽  
A. Hernández ◽  
C. Valencia ◽  
A. López ◽  
N. Giraldo ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Late Onset ◽  
Diagnostic Challenge

scholarly journals Recomendações para o Diagnóstico da Forma Tardia da Doença de Pompe

2014 ◽  
Vol 27 (4) ◽  
pp. 525 ◽  
Author(s):  
Luís Brito-Avô ◽  
José Delgado Alves ◽  
João Matos Costa ◽  
Ana Valverde ◽  
Lélita Santos ◽  
...  
Keyword(s):  
Muscle Biopsy ◽  
Pompe Disease ◽  
Storage Disease ◽  
Age Of Onset ◽  
Late Onset ◽  
Neuromuscular Diseases ◽  
Glycogen Storage Disease Type ◽  
Glycogen Storage ◽  
Diagnostic Challenge

<strong>Introduction:</strong> Pompe disease is a progressive and debilitating autossomal recessive myopathy due to mutations in lysossomal acid-α-glucosidase. Its late-onset form has a heterogeneous presentation mimicking other neuromuscular diseases, leading to diagnostic challenge.<br /><strong>Objective:</strong> To develop consensus based recommendations for the diagnosis of late-onset Pompe Disease.<br /><strong>Material and Methods:</strong> Bibliographic review and analysis of an opinion questionnaire applied to a group of specialists with expertise in the diagnosis of several myopathies and lysossomal storage disorders. Discussed in consensus meeting.<br /><strong>Recommendations:</strong> Patients with a progressive limb-girdle weakness, fatigue, cramps and muscle pain should be evaluated with CK levels, electromyography, dynamic spirometry and muscle biopsy in inconclusive cases. Suspected cases and those in which muscle biopsy could not allow other diagnosis should be screened for lysossomal acid-α-glucosidase deficiency with DBS (dried blood spot). The diagnosis should be confirmed by determination of lysossomal acid-α-glucosidase activity in a second sample and lysossomal acid-α-glucosidase gene sequencing.<br /><strong>Keywords:</strong> Age of Onset; Consensus; Glycogen Storage Disease Type II.

scholarly journals Fever of unknown origin, anemia and thrombocytosis as early symptoms and signs of a late-onset polymialgia rheumatica: A diagnostic challenge

2012 ◽  
Vol 32 (3) ◽  
pp. 322-323
Author(s):  
Pasquale Niscola ◽  
Laura Scaramucci ◽  
Marco Giovannini ◽  
Andrea Tendas ◽  
Luca Cupelli ◽  
...  
Keyword(s):  
Fever Of Unknown Origin ◽  
Late Onset ◽  
Unknown Origin ◽  
Diagnostic Challenge ◽  
Early Symptoms ◽  
Symptoms And Signs

scholarly journals Features of late-onset systemic lupus erythematosus

2021 ◽  
Vol 30 (3) ◽  
pp. 121-124
Author(s):  
Alexandra Constantinescu ◽  
◽  
Claudia Cobilinschi ◽  
Elena Gradinaru ◽  
Ioana Saulescu ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Late Onset ◽  
Systemic Lupus ◽  
Diagnostic Challenge ◽  
Disease Subtype ◽  
Distinct Disease ◽  
Physician Awareness ◽  
Chronic Autoimmune Disease ◽  
Onset Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease, characterized by multiorgan involvement, most commonly targeting the skin, joints and kidneys. Late-onset disease occurs in patients over the age of 50 and represents a diagnostic challenge, as it is less frequently encountered and it may exhibit a more unusual clinical and paraclinical picture. The aim of this paper is to highlight two cases of SLE diagnosed in female patients of considerably advanced ages, 81 and 72 years respectively, in order to enhance physician awareness with regard to this distinct disease subtype.

The Diagnostic Challenge of the Late-Onset Frontal Lobe Syndrome

2017 ◽  
Vol 78 (9) ◽  
pp. e1197-e1203 ◽  
Author(s):  
Everard G. B. Vijverberg ◽  
Flora Gossink ◽  
Welmoed Krudop ◽  
Sietske Sikkes ◽  
Cora Kerssens ◽  
...  
Keyword(s):  
Frontal Lobe ◽  
Late Onset ◽  
Diagnostic Challenge ◽  
Frontal Lobe Syndrome
Sign in / Sign up

Export Citation Format

Share Document