scholarly journals Fever of unknown origin, anemia and thrombocytosis as early symptoms and signs of a late-onset polymialgia rheumatica: A diagnostic challenge

2012 ◽  
Vol 32 (3) ◽  
pp. 322-323
Author(s):  
Pasquale Niscola ◽  
Laura Scaramucci ◽  
Marco Giovannini ◽  
Andrea Tendas ◽  
Luca Cupelli ◽  
...  
Keyword(s):  
Fever Of Unknown Origin ◽  
Late Onset ◽  
Unknown Origin ◽  
Diagnostic Challenge ◽  
Early Symptoms ◽  
Symptoms And Signs

scholarly journals TNFRSF1A gene variant identified in a boy with recurrent episodes of fever

2018 ◽  
Vol 146 (9-10) ◽  
pp. 577-580
Author(s):  
Srdja Jankovic ◽  
Goran Djuricic ◽  
Aleksandra Radosavljevic ◽  
Dragana Janic
Keyword(s):  
Fever Of Unknown Origin ◽  
Periodic Fever ◽  
Tumor Necrosis Factor Receptor ◽  
Unknown Origin ◽  
Recurrent Fever ◽  
Diagnostic Challenge ◽  
Periodic Fever Syndromes ◽  
Tnfrsf1a Gene ◽  
Febrile Condition ◽  
Fever Syndromes

Introduction. Fever of unknown origin is an important diagnostic challenge. Although rare, periodic fever syndromes may often present with a chronic or recurrent febrile condition with a variable temporal pattern of occurrence. Although clinical characteristics often indicate the syndrome in question, there are many atypical forms, and the genotype?phenotype relationship is highly complex, warranting in many cases the designation of a ?syndrome spectrum? rather than a syndrome per se. The aim of this paper was to present a boy with recurrent fever of unknown origin. Case outline. We hereby present a boy with recurrent fever of unknown origin who was by clinically guided partial exome sequencing found to have a heterozygous variant 434A>G in the TNFRSF1A gene, otherwise connected with tumor necrosis factor receptor-associated periodic fever syndrome. The patient responded well to short courses of glucocorticoids and is no longer subjected to unnecessary antibiotic treatment he had frequently received in the past. Conclusion. Periodic fever syndromes should be kept in mind as a differential diagnostic possibility in children with fever of unknown origin.

scholarly journals Fever of Unknown Origin as an Onset for Late-Onset Systemic Lupus Erythematous

Thrita ◽  
2014 ◽  
Vol 3 (1) ◽  
Author(s):  
Nasrin Shoar ◽  
Saeed Shoar ◽  
Sayed Shahabuddin Hoseini ◽  
Zahra Abdi Layaei
Keyword(s):  
Fever Of Unknown Origin ◽  
Late Onset ◽  
Unknown Origin ◽  
Systemic Lupus Erythematous ◽  
Systemic Lupus

Generalized lymphadenopathy in patient with fever of unknown origin as a differential diagnostic challenge - case report

2021 ◽  
pp. 1-13
Author(s):  
Sofija Sekulic Markovic ◽  
Ivana Rakovic ◽  
Sara Petrovic ◽  
Dusica Petrovic Rodic ◽  
Nenad Zornic ◽  
...  
Keyword(s):  
Case Report ◽  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Diagnostic Challenge ◽  
Generalized Lymphadenopathy

Published in May - 2021

scholarly journals Fever of Unknown Origin - A Child With an Unusual Case of Juvenile Idiopathic Arthritis

2020 ◽  
Vol 4 (1) ◽  
pp. 459-461
Author(s):  
Purnima Gyawali ◽  
Deepika Gyawali ◽  
Sharda Acharya
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Fever Of Unknown Origin ◽  
Pediatric Population ◽  
Unknown Origin ◽  
Diagnostic Challenge ◽  
Laboratory Assessment ◽  
Medical College ◽  
Unexplained Fever ◽  
History Of ◽  
High Index Of Suspicion

Fever of unknown origin in the pediatric population is fever >38.3°C (101°F) of at least seven days' duration, in which no diagnosis is apparent after initial outpatient or hospital evaluation that includes a careful history and physical examination and initial laboratory assessment. Fever of unknown origin is a diagnostic challenge, with a broad spectrum of causes classified as infectious, malignant/neoplastic, rheumatic/inflammatory, and miscellaneous disorders. A high index of suspicion should be kept for juvenile idiopathic arthritis in children presenting with unexplained fever and joint symptoms and should be appropriately managed. The case described here is of a 13-year-old female from Nepal, who presented to the Pediatric outpatient department of KIST Medical College and Teaching Hospital with a history of fever and arthralgia for three months.

scholarly journals Systemic Onset Juvenile Idiopathic Arthritis (sJIA) or Still's Disease: A Diagnostic Challenge; while Presented as Fever of Unknown Origin. 2 Cases

2019 ◽  
Vol 10 (1) ◽  
pp. 84-88
Author(s):  
Gule Tajkia ◽  
Syed Khairul Amin ◽  
Shamim Rima ◽  
Soma Halder ◽  
Fabia Hannan
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Chronic Inflammatory Disease ◽  
Joint Disease ◽  
Unknown Etiology ◽  
Still’S Disease ◽  
Diagnostic Challenge ◽  
Still's Disease ◽  
Systemic Onset

Systemic-onset juvenile idiopathic arthritis (sJIA) or Still's disease is a chronic inflammatory disease of unknown etiology belongs to the group of Juvenile Idiopathic Arthritis. In contrast to other JIA patients in whom the joint disease usually overshadows the more general symptomatology, in Systemic-onset juvenile idiopathic arthritis (sJIA) extra-articular features such as spiking fever, hepatosplenomegaly, lymphadenopathy, rash, pleurisy, or pericarditis, and vasculopathy are most prominent. Thus the onset of disease can be vary nonspecific and may suggest bacterial or viral infection, malignancy or other rheumatic disease. As it is highly characterized by its extra-articular systemic illness features, in some ways, it resembles a fever of unknown origin. We present 2 cases of fever of unknown origin, initially presented with fever and other extra-articular features, without any arthritis, but after several months develops arthritis and finally diagnosed as Systemic-onset juvenile idiopathic arthritis (sJIA) or Still's disease . Anwer Khan Modern Medical College Journal Vol. 10, No. 1: Jan 2019, P 84-88

scholarly journals Fever of unknown origin. A changing clinical spectrum and a diagnostic challenge

Case reports ◽  
2020 ◽  
Vol 6 (2) ◽  
pp. 89-91
Author(s):  
Moisés Casarrubias-Ramírez
Keyword(s):  
Fever Of Unknown Origin ◽  
Case Reports ◽  
Unknown Origin ◽  
Clinical Spectrum ◽  
Diagnostic Challenge

This issue of Case Reports presents two cases of fever of unknown origin (FUO) that illustrate the etiological diversity and diagnostic complexity of this condition.

scholarly journals Focused Diagnostic Approach to A Patient with Fever of Unknown Origin (FUO): A Review

2013 ◽  
Vol 3 (1) ◽  
pp. 27-34
Author(s):  
Jamal Uddin Ahmed ◽  
Muhammad Abdur Rahim ◽  
Md. Delwar Hossain ◽  
AKM Shaheen Ahmed ◽  
AKM Musa ◽  
...  
Keyword(s):  
Laboratory Tests ◽  
Fever Of Unknown Origin ◽  
Diagnostic Testing ◽  
Unknown Origin ◽  
Specific Pattern ◽  
Diagnostic Approach ◽  
Atypical Presentation ◽  
Main Difficulty ◽  
Diagnostic Challenge ◽  
Therapeutic Trials

Fever of unknown origin (FUO) is a diagnostic challenge for clinicians. Disorders presenting as fever of unknown origin are varied and extensive. Clinicians often find themselves hopeless with a patient with FUO and try to catch a straw by doing every conceivable test and run therapeutic trials in order to diagnose all of the myriad causes of FUO that are in fact part of the differential diagnosis of FUO in general. The main difficulty with diagnostic testing in patients with FUO is that it is unfocused. All disorders have a specific pattern of organ involvement. In a patient with FUO, there are almost always one or more clues from the history, physical examination, or nonspecific laboratory tests that suggest a particular diagnosis or at least limit diagnostic possibilities. It is worthy to remember that fever of unknown origin is more often caused by an atypical presentation of a common entity than by a rare disorder. Thus a focused diagnostic approach can minimize the miseries of both the clinician & the patient. Birdem Med J 2013; 3(1): 27-34 DOI: http://dx.doi.org/10.3329/birdem.v3i1.17124

Fever of unknown origin caused by late-onset rheumatoid arthritis

Heart & Lung ◽  
2006 ◽  
Vol 35 (1) ◽  
pp. 70-73 ◽  
Author(s):  
Burke A. Cunha ◽  
Uzma Syed ◽  
Naveed Hamid
Keyword(s):  
Rheumatoid Arthritis ◽  
Fever Of Unknown Origin ◽  
Late Onset ◽  
Unknown Origin

scholarly journals A Toddler With Prolonged Fever and Intermittent Cough

2019 ◽  
Vol 6 ◽  
pp. 2333794X1882299
Author(s):  
Carson Gill ◽  
Ori Scott ◽  
Carolyn E. Beck
Keyword(s):  
Differential Diagnosis ◽  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Retropharyngeal Abscess ◽  
Diagnostic Challenge ◽  
Prolonged Fever ◽  
Common Etiology ◽  
Physical Examinations

Fever of unknown origin is an important diagnostic challenge in pediatrics that requires a thoughtful approach. The differential diagnosis is broad and includes infectious, autoimmune, oncologic, neurologic, genetic, and iatrogenic causes. Infection remains the most common etiology, and uncommon presentations of infections are still more likely than classic presentations of rare conditions. We report a case of a retropharyngeal abscess in a toddler whose presentation is marked by a prolonged fever (>3 weeks). This case highlights the importance of close follow-up with serially repeated history and physical examinations to guide the evaluation of a patient with fever of unknown origin.

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