scholarly journals Contact with renal sinus is associated with poor prognosis in surgically treated pT1 clear cell renal cell carcinoma

2020 ◽  
Vol 27 (8) ◽  
pp. 657-662 ◽  
Author(s):  
Keita Izumi ◽  
Kazutaka Saito ◽  
Takayuki Nakayama ◽  
Shohei Fukuda ◽  
Hiroshi Fukushima ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Poor Prognosis ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma ◽  
Renal Sinus

scholarly journals Increased expression of MUC3A is associated with poor prognosis in localized clear-cell renal cell carcinoma

Oncotarget ◽  
2016 ◽  
Vol 7 (31) ◽  
pp. 50017-50026 ◽  
Author(s):  
Tian Niu ◽  
Yidong Liu ◽  
Yuan Zhang ◽  
Qiang Fu ◽  
Zheng Liu ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Poor Prognosis ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma

scholarly journals Overexpression of BMP1 reflects poor prognosis in clear cell renal cell carcinoma

2019 ◽  
Vol 27 (5) ◽  
pp. 330-340 ◽  
Author(s):  
Wen Xiao ◽  
Xuegang Wang ◽  
Tao Wang ◽  
Jinchun Xing
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Poor Prognosis ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma

617 GENOMIC ALTERATIONS ASSOCIATED WITH METASTASIS AND POOR PROGNOSIS IN CLEAR CELL RENAL CELL CARCINOMA

2010 ◽  
Vol 183 (4S) ◽  
Author(s):  
Jimsgene Sanjmyatav ◽  
Carsten Schwaenen ◽  
Sven Wessendorf ◽  
Markus Kreuz ◽  
Thomas Steiner ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Poor Prognosis ◽  
Clear Cell ◽  
Genomic Alterations ◽  
Cell Renal Cell Carcinoma

Intratumoural heterogeneity may hinder precision medicine strategies in patients with clear cell renal cell carcinoma

2018 ◽  
Vol 71 (5) ◽  
pp. 467-471 ◽  
Author(s):  
Maria Rosaria Raspollini ◽  
Ilaria Montagnani ◽  
Rodolfo Montironi ◽  
Francesca Castiglione ◽  
Guido Martignoni ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Precision Medicine ◽  
Renal Cell ◽  
Clear Cell ◽  
Molecular Heterogeneity ◽  
Precision Oncology ◽  
Cell Renal Cell Carcinoma ◽  
Renal Sinus ◽  
The Moment

Clear cell renal cell carcinoma (ccRCC) is an heterogeneous tumour at architectural, cellular and molecular level, a reason why the 2014 International Society of Urological Pathology consensus recommended wide sampling of RCC masses to include at least 1 block/cm of tumour together with perpendicular sections of the tumour/perinephric fat interface and the tumour/renal sinus interface. Intratumoural molecular heterogeneity may be a limitation at the moment of defining precision medicine strategies based on gene mutation status. This study analyses the presence of any mutation of KRAS, NRAS, BRAF, PIK3CA, ALK, ERBB2, DDR2, MAP2K1, RET and EGFR genes in 20 tissue blocks from a case of ccRCC and its metastasis. We observed the presence of the mutation at pH1047R of PIK3CA gene in five samples of the tumour, while the remaining 15 samples did not show any mutation at PIK3CA or any other investigated gene. There is a great need to develop novel RCC sampling strategies to overcome tumour heterogeneity prior to define precision oncology strategies.

scholarly journals Decreased expression of JMJD3 predicts poor prognosis of patients with clear cell renal cell carcinoma

2017 ◽  
Vol 14 (2) ◽  
pp. 1550-1560 ◽  
Author(s):  
Jiajun Wang ◽  
Li Liu ◽  
Qilai Long ◽  
Qi Bai ◽  
Yu Xia ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Poor Prognosis ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma
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