This is a rare case of a wild squirrel that was diagnosed with angiostrongyliasis characterized by the presence of larvae-induced eosinophilic meningoencephalomyelitis. A wild, intact, male Pallas’s squirrel (Callosciurus erythraeus) of unknown age was presented with a history of progressive paralysis in both forelimbs and hindlimbs. Gradually, the squirrel showed signs of deterioration, found dead and submitted for a complete pathological diagnosis. Necropsy revealed the presence of severe and diffuse congestion in the subarachnoid space of the brain and mild congestion in the spinal cord. Microscopically, severe meningoencephalomyelitis and interstitial pneumonia were consistent with lesions induced by Angiostrongylus cantonensis (A. cantonensis). Although A. cantonensis has been widely studied in rabbits, mice and humans, infection in squirrels has not been documented. This may be the first reported case of angiostrongyliasis in the Pallas’s squirrel.