DNA sequence of the skeletal muscle calcium release channel cDNA and verification of the Arg615→ Cys615 mutation, associated with porcine malignant hyperthermia, in Norwegian Landrace pigs

2009 ◽  
Vol 23 (5) ◽  
pp. 395-402 ◽  
Author(s):  
I. HARBITZ ◽  
T. KRISTENSEN ◽  
M. BOSNES ◽  
S. KRAN ◽  
W. DAVIES
Keyword(s):  
Skeletal Muscle ◽  
Malignant Hyperthermia ◽  
Dna Sequence ◽  
Calcium Release ◽  
Calcium Release Channel ◽  
Release Channel ◽  
Muscle Calcium

Electron cryomicroscopy and angular reconstitution used to visualize the skeletal muscle calcium release channel

1995 ◽  
Vol 2 (1) ◽  
pp. 18-24 ◽  
Author(s):  
Irina I. Serysheva ◽  
Elena V. Orlova ◽  
Wah Chiu ◽  
Michael B. Sherman ◽  
Susan L. Hamilton ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Calcium Release ◽  
Electron Cryomicroscopy ◽  
Calcium Release Channel ◽  
Release Channel ◽  
Muscle Calcium

scholarly journals The Skeletal Muscle Calcium Release Channel

Cell ◽  
2000 ◽  
Vol 102 (4) ◽  
pp. 499-509 ◽  
Author(s):  
Jerry P Eu ◽  
Junhui Sun ◽  
Le Xu ◽  
Jonathan S Stamler ◽  
Gerhard Meissner
Keyword(s):  
Skeletal Muscle ◽  
Calcium Release ◽  
Calcium Release Channel ◽  
Release Channel ◽  
Muscle Calcium

Heat Production During Anesthetic-Induced Malignant Hyperthermia

2001 ◽  
Vol 21 (2) ◽  
pp. 169-179 ◽  
Author(s):  
Thomas E. Nelson
Keyword(s):  
Skeletal Muscle ◽  
Malignant Hyperthermia ◽  
Heat Production ◽  
Calcium Release ◽  
Calcium Release Channel ◽  
Release Channel ◽  
Inhaled Anesthetics ◽  
Continuous Release ◽  
Gene Coding ◽  
Life Threatening

Malignant hyperthermia (MH) is a pharmacogenetic disease which predisposes to the trigger of a life-threatening, hypermetabolic syndrome by potent inhaled anesthetics and by depolarizing skeletal muscle relaxants. Heat production in the anesthetized MH can be profound with 5-fold increases in oxygen consumption. The trigger anesthetics cause an abnormal, sustained rise in myoplasmic calcium levels. Possible mechanisms by which continuous release of calcium from skeletal muscle sarcoplasmic reticulum stores can produce the profound hyperthermia are discussed. Mutations in the gene coding the ryanodine receptor calcium release channel have been found in MH families and these mutant channels may be the functionsl basis for MH.

Two structural configurations of the skeletal muscle calcium release channel

1996 ◽  
Vol 3 (6) ◽  
pp. 547-552 ◽  
Author(s):  
Elena V. Orlova ◽  
Irina I. Serysheva ◽  
Marin van Heel ◽  
Susan L. Hamilton ◽  
Wah Chiu
Keyword(s):  
Skeletal Muscle ◽  
Calcium Release ◽  
Calcium Release Channel ◽  
Release Channel ◽  
Structural Configurations ◽  
Muscle Calcium

scholarly journals Structure of the Skeletal Muscle Calcium Release Channel Activated with Ca2+ and AMP-PCP

1999 ◽  
Vol 77 (4) ◽  
pp. 1936-1944 ◽  
Author(s):  
I.I. Serysheva ◽  
M. Schatz ◽  
M. van Heel ◽  
W. Chiu ◽  
S.L. Hamilton
Keyword(s):  
Skeletal Muscle ◽  
Calcium Release ◽  
Calcium Release Channel ◽  
Release Channel ◽  
Muscle Calcium
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