Intraepidermal collagen type VII in dystrophic epidermolysis bullosa: report of five new cases

1992 ◽  
Vol 126 (3) ◽  
pp. 222-230 ◽  
Author(s):  
R.J. PHILLIPS ◽  
J.I. HARPER ◽  
B.D. LAKE
Keyword(s):  
Epidermolysis Bullosa ◽  
Collagen Type ◽  
Dystrophic Epidermolysis Bullosa ◽  
Collagen Type Vii

scholarly journals Inversa Dystrophic Epidermolysis Bullosa Is Caused by Missense Mutations at Specific Positions of the Collagenic Domain of Collagen Type VII

2010 ◽  
Vol 130 (10) ◽  
pp. 2508-2511 ◽  
Author(s):  
Christine Chiaverini ◽  
Alexandra V. Charlesworth ◽  
Monia Youssef ◽  
Jean-François Cuny ◽  
Smail H. Rabia ◽  
...  
Keyword(s):  
Epidermolysis Bullosa ◽  
Collagen Type ◽  
Missense Mutations ◽  
Dystrophic Epidermolysis Bullosa ◽  
Collagen Type Vii

scholarly journals Genetic Linkage Between the Collagen Type VII Gene COL7A1 and Pretibial Epidermolysis Bullosa with Lichenoid Features

1995 ◽  
Vol 104 (5) ◽  
pp. 803-805 ◽  
Author(s):  
Jean Marie Naeyaert ◽  
Lieve Nuytinck ◽  
Sylvia De Bie ◽  
Hilde Beele ◽  
André Kint ◽  
...  
Keyword(s):  
Epidermolysis Bullosa ◽  
Genetic Linkage ◽  
Collagen Type ◽  
Collagen Type Vii

scholarly journals Fluorescence overlay antigen mapping of the epidermal basement membrane zone: III. Topographic staining and effective resolution.

1995 ◽  
Vol 43 (7) ◽  
pp. 649-656 ◽  
Author(s):  
S Bruins ◽  
M C De Jong ◽  
K Heeres ◽  
M H Wilkinson ◽  
M F Jonkman ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Epidermolysis Bullosa ◽  
Collagen Type ◽  
Basement Membrane Zone ◽  
Resolving Power ◽  
Resolution Limit ◽  
Double Immunofluorescence ◽  
Collagen Type Vii ◽  
Epidermal Basement Membrane ◽  
Reference Markers

In this third study on the fluorescence overlay antigen mapping (FOAM) technique, we have addressed the question of which differences of antigen distributions close to the resolving power of the light microscope can be distinguished. An answer to this question should provide clues to future applications of the technique aiming at the topographic differentiation of IgG deposits displayed at the epidermal basement membrane zone (EBMZ) in certain bullous skin disorders. For the present purpose we have developed a topographic staining model in human skin, using structural EBMZ antigens as topographic reference markers. The distribution of these markers relative to one another is visualized in FOAM images obtained by selective double immunofluorescence tracing and videomicroscopic overlay imaging. The theoretical resolution limit of the technique is discussed and suggests an effective lower limit of some 60-65 nm. Although this limit is not reached under present conditions, our results show that it is possible to distinguish topographic differences of antigen distributions with an upper resolution limit of 200 +/- 50 nm. Furthermore, our findings indicate that collagen Type VII and beta 4 integrin are the most suitable molecules to serve as topographic reference markers in future applications of the technique aiming at the differentiation of bullous pemphigoid (BP) and epidermolysis bullosa acquisita (EBA). Preliminary results on this topic are most promising indeed.

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