Non-invasive quantitation of liver iron-overload by magnetic resonance imaging

Determination of liver iron concentration by magnetic resonance imaging (MRI) is becoming the new technique of choice for the diagnosis of iron overload in hereditary haemochromatosis and other liver iron surcharge diseases. Determination of hepatic iron concentration obtained by liver biopsy has been the gold standard for years. The development of MRI techniques, via signal intensity ratio methods or relaxometry, has provided a non-invasive and more accurate approach to the diagnosis of liver iron overload. This article reviews the available MRI methods for the determination of liver iron concentration and also evaluates the technique for the diagnosis and quantification of iron overload in different clinical practice scenarios.

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Comparison of Tissue Elastography With Magnetic Resonance Imaging T2* and Serum Ferritin Quantification in Detecting Liver Iron Overload in Patients With Thalassemia Major

Clinical Gastroenterology and Hepatology ◽

10.1016/j.cgh.2016.08.046 ◽

2017 ◽

Vol 15 (2) ◽

pp. 292-298.e1 ◽

Cited By ~ 2

Author(s):

Nirav Pipaliya ◽

Dattatray Solanke ◽

Pathik Parikh ◽

Meghraj Ingle ◽

Ratna Sharma ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Iron Overload ◽

Serum Ferritin ◽

Thalassemia Major ◽

Resonance Imaging ◽

Liver Iron ◽

Liver Iron Overload ◽

Tissue Elastography

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Myocardial and liver iron overload, assessed using T2* magnetic resonance imaging with an excel spreadsheet for post processing in Tunisian thalassemia major patients

Annals of Hematology ◽

10.1007/s00277-016-2841-5 ◽

2016 ◽

Vol 96 (1) ◽

pp. 133-139 ◽

Cited By ~ 5

Author(s):

Monia Ouederni ◽

Monia Ben Khaled ◽

Fethi Mellouli ◽

Elhem Ben Fraj ◽

Nawel Dhouib ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Iron Overload ◽

Thalassemia Major ◽

Post Processing ◽

Resonance Imaging ◽

Liver Iron ◽

Excel Spreadsheet ◽

Liver Iron Overload

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Quantification of severe liver iron overload using MRI offset echoes

Acta Radiologica Open ◽

10.1177/2047981614568910 ◽

2015 ◽

Vol 4 (5) ◽

pp. 204798161456891 ◽

Cited By ~ 1

Author(s):

Henric Rydén ◽

Mikael Skorpil

Keyword(s):

Magnetic Resonance Imaging ◽

Relaxation Time ◽

Magnetic Resonance ◽

Iron Overload ◽

Resonance Imaging ◽

Severe Liver ◽

Liver Iron ◽

Liver Iron Overload ◽

Magnetic Resonance Imaging Mri ◽

Iron Concentrations

Magnetic resonance imaging (MRI) has become the clinical standard to estimate liver iron overload. The most commonly used method is to measure the transversal relaxation time, T2*, from a multi gradient recalled echo sequence (MGRE). While this technique is reliable in low to moderate liver iron concentrations (LIC), it will be inaccurate when it is severe. We report a case with severe liver hemochromatosis and show the benefit of using an easily implemented MRI offset echo sequence to more accurately estimate LIC. After adjusting treatment, both Ferritin and LIC decreased. Using standard MGRE this reduction could not have been detected.

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