scholarly journals Quantification of severe liver iron overload using MRI offset echoes

2015 ◽  
Vol 4 (5) ◽  
pp. 204798161456891 ◽  
Author(s):  
Henric Rydén ◽  
Mikael Skorpil
Keyword(s):  
Magnetic Resonance Imaging ◽  
Relaxation Time ◽  
Magnetic Resonance ◽  
Iron Overload ◽  
Resonance Imaging ◽  
Severe Liver ◽  
Liver Iron ◽  
Liver Iron Overload ◽  
Magnetic Resonance Imaging Mri ◽  
Iron Concentrations

Magnetic resonance imaging (MRI) has become the clinical standard to estimate liver iron overload. The most commonly used method is to measure the transversal relaxation time, T2*, from a multi gradient recalled echo sequence (MGRE). While this technique is reliable in low to moderate liver iron concentrations (LIC), it will be inaccurate when it is severe. We report a case with severe liver hemochromatosis and show the benefit of using an easily implemented MRI offset echo sequence to more accurately estimate LIC. After adjusting treatment, both Ferritin and LIC decreased. Using standard MGRE this reduction could not have been detected.

Accuracy of Magnetic Resonance Imaging in Diagnosis of Liver Iron Overload: A Systematic Review and Meta-analysis

2015 ◽  
Vol 13 (1) ◽  
pp. 55-63.e5 ◽  
Author(s):  
Maria Sarigianni ◽  
Aris Liakos ◽  
Efthymia Vlachaki ◽  
Paschalis Paschos ◽  
Eleni Athanasiadou ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Systematic Review ◽  
Magnetic Resonance ◽  
Iron Overload ◽  
Meta Analysis ◽  
Resonance Imaging ◽  
Liver Iron ◽  
Liver Iron Overload

Improved T2* assessment in liver iron overload by magnetic resonance imaging

2009 ◽  
Vol 27 (2) ◽  
pp. 188-197 ◽  
Author(s):  
Vincenzo Positano ◽  
Benedetta Salani ◽  
Alessia Pepe ◽  
Maria Filomena Santarelli ◽  
Daniele De Marchi ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Iron Overload ◽  
Resonance Imaging ◽  
Liver Iron ◽  
Liver Iron Overload

scholarly journals Stratification for Age in Non-Transfusion-Dependent Thalassemia: Data from a National Italian Networking

Blood ◽  
2018 ◽  
Vol 132 (Supplement 1) ◽  
pp. 3639-3639
Author(s):  
Alessia Pepe ◽  
Laura Pistoia ◽  
Nicola Romano ◽  
Giuseppe Colaci ◽  
Aurelio Maggio ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Iron Overload ◽  
Pediatric Patients ◽  
Cardiac Complications ◽  
Hepatic Iron ◽  
Resonance Imaging ◽  
Liver Iron ◽  
Cardiac Iron ◽  
Magnetic Resonance Imaging Mri

Abstract Background: Non-transfusion-dependent thalassemia (NTDT) is a term used to indicate patients who do not require lifelong regular transfusions for survival. Morbidity in NTDT patients is more common and serious than previously recognized. This study aimed to examine the association of age with the presence of iron overload assessed by Magnetic Resonance Imaging (MRI) and cardiovascular and endocrine complications in NTDT patients. Methods: We considered 170 patients with thalassemia intermedia never transfused o who received occasional transfusions consecutively enrolled in the Myocardial Iron Overload in Thalassemia (MIOT) project. Iron overload was quantified by the T2* Magnetic Resonance Imaging (MRI) technique. All complications were classified according to international guidelines. Results: Six groups of patients were identified: age<18 years (N=7), age 18-30 years (N=36), age 30-40 years (N=48), age 40-50 (N=45), age 50-60 years (N=26), and age≥60 years (N=8). The Table shows the comparison among the groups. The youngest patient showing hepatic iron (MRI liver iron concentration-LIC>3 mg/g dw) had 9 years of age and the frequency of hepatic iron did not significantly increase with age. Only one patient showed cardiac iron (global heart T2*<20 ms). Diabetes appeared only in patients with more than 50 years and showed a trend toward increasing with increasing age. Hypothyroidism and osteoporosis were not present in pediatric patients and were not associated to age. Hypogonadism was not present in patients with less than 30 years and its frequency was comparable among the age groups. No patient showed hypoparathyroidism. Only patients older than 30 years showed a cardiac complication (heart failure or arrhythmias), but the rate did not significantly increase with increasing age. Conclusions: Our data in NTDT are indicative of high rate of liver iron overload at early age and extremely rare cardiac iron overload. Endocrine or cardiac complications were not present in pediatric patients but in adult patients the frequency did not increase with advancing age. Table. Table. Disclosures Pepe: Chiesi Farmaceutici S.p.A., ApoPharma Inc., and Bayer: Other: No profit support.

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