Pyoderma gangrenosum associated with Takayasu's arteritis

We report a Caucasian female who presented with simultaneous erythema nodosum and pyoderma gangrenosum due to underlying Takayasu’s arteritis. Takayasu’s arteritis is a chronic large vessel vasculitis of unknown cause. The disease has a worldwide distribution but is most commonly seen in Asian populations. There is a strong predilection for young females. The clinical presentation is variable, but mostly derives from stenosis or occlusion of affected arteries, resulting in claudication and ischemia. Skin manifestations are observed in up to 28% of patients with Takayasu’s arteritis, with erythema nodosum reported more frequently in Caucasians. Pyoderma gangrenosum is more common in Asian patients. This report demonstrates the importance to exclude Takayasu’s arteritis in patients with such skin lesions.

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Takayasu’s arteritis with pyoderma gangrenosum and necrotizing vasculitis

Clinical and Experimental Dermatology ◽

10.1111/j.1365-2230.2009.03534.x ◽

2010 ◽

Vol 35 (3) ◽

pp. 329-330 ◽

Cited By ~ 2

Author(s):

A. Minagawa ◽

H. Uhara ◽

T. Saida

Keyword(s):

Pyoderma Gangrenosum ◽

Takayasu’S Arteritis ◽

Takayasu's Arteritis ◽

Necrotizing Vasculitis

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Cyclosporine Treatment of Severe Recalcitrant Pyoderma Gangrenosum in a Patient With Takayasu's Arteritis

Archives of Dermatology ◽

10.1001/archderm.1991.01680100135027 ◽

1991 ◽

Vol 127 (11) ◽

pp. 1731 ◽

Cited By ~ 8

Author(s):

S. Honor Fullerton

Keyword(s):

Pyoderma Gangrenosum ◽

Takayasu’S Arteritis ◽

Takayasu's Arteritis

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Folgoration as an Example of Pathergy in a Patient Affected by Pyoderma Gangrenosum and Takayasu's Arteritis

Dermatology Research and Practice ◽

10.1155/2009/393452 ◽

2009 ◽

Vol 2009 ◽

pp. 1-3 ◽

Cited By ~ 3

Author(s):

A. G. Richetta ◽

S. D'Epiro ◽

C. Mattozzi ◽

S. Giancristoforo ◽

S. Calvieri

Keyword(s):

Rheumatoid Arthritis ◽

Ulcerative Colitis ◽

Pyoderma Gangrenosum ◽

Monoclonal Gammopathy ◽

Takayasu’S Arteritis ◽

Clinical Manifestations ◽

Neutrophilic Dermatosis ◽

Minor Trauma ◽

Takayasu's Arteritis ◽

Unknown Aetiology

Pyoderma gangrenosum (PG) is a neutrophilic dermatosis of unknown aetiology. Clinical manifestations of PG are characterized by destructive, necrotizing, and noninfective ulceration of the skin. 20–30% of cases are initiated and aggravated by minor trauma or surgery, a phenomenon named pathergy. PG is related to several autoimmune diseases including ulcerative colitis, Crohn's disease, rheumatoid arthritis, and monoclonal gammopathy. The association with Takayasu's arteritis (TA), a chronic inflammatory and stenotic disease of large and medium-sized arteries, is instead less common. We report a case of PG associated with TA that was induced by an accident with folgoration of the skin; in this case the folgoration can be considered as an exemple of Pathergy, that is, a characteristic feature of PG.

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