Vasoactive intestinal polypeptide (VIP) increases vaginal blood flow and inhibits uterine smooth muscle activity in women

Immunocytochemical studies habe shown that many peptides which profoundly affect the endocrine and exocrine functions of the pancreas are localized to neurons. In the cat, such peptidergic nerves appear to innervate ganglia, islets and blood vessels of the pancreas, whereas their contributions to exocrine cells are minor. Our studies suggest that pancreatic ganglia represent one major site of action of the peptides and that, in addition, nerves containing the vasoactive intestinal polypeptide and gastrin/CCK-related peptides profoundly affect pancreatic blood flow and insulin secretion, respectively.

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Aspects on the Role of Tachykinins and Vasoactive Intestinal Polypeptide in Control of Secretion, Motility and Blood Flow in the Gut

Advances in Experimental Medicine and Biology - Sensory Nerves and Neuropeptides in Gastroenterology ◽

10.1007/978-1-4899-0744-8_21 ◽

1991 ◽

pp. 233-240 ◽

Cited By ~ 10

Author(s):

Elvar Theodorsson ◽

Bengt Smedfors ◽

Per Hellström ◽

Olof Söder ◽

Andreas Aly ◽

...

Keyword(s):

Blood Flow ◽

Vasoactive Intestinal Polypeptide ◽

Intestinal Polypeptide

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Vasoactive intestinal polypeptide reduces hydrochloric acid-induced duodenal mucosal permeability

AJP Gastrointestinal and Liver Physiology ◽

10.1152/ajpgi.1993.264.2.g272 ◽

1993 ◽

Vol 264 (2) ◽

pp. G272-G279 ◽

Cited By ~ 3

Author(s):

O. Nylander ◽

E. Wilander ◽

G. M. Larson ◽

L. Holm

Keyword(s):

Blood Pressure ◽

Blood Flow ◽

Vasoactive Intestinal Polypeptide ◽

Lesion Score ◽

Morphological Examination ◽

Mucosal Permeability ◽

Doppler Flowmetry ◽

Arterial Blood ◽

51Cr Edta ◽

Intestinal Polypeptide

The duodenum in anesthetized rats was perfused with HCl, and mucosal integrity was assessed by measuring the clearance of 51Cr-labeled EDTA from blood to lumen and/or by morphological examination (lesion score). Duodenal blood flow was determined by laser Doppler flowmetry and luminal alkalinization as well as H+ disappearance by backtitration. Intravenous infusion of vasoactive intestinal polypeptide (VIP; 13.5 micrograms.kg-1.h-1) increased luminal alkalinization threefold and decreased clearance of 51Cr-EDTA by 50%. VIP also decreased arterial blood pressure and induced a small and irregular decrease in duodenal blood flow. Perfusion with 10 mM HCl increased clearance of 51Cr-EDTA 2.1-fold, but the lesion score was not different from that in saline-perfused animals. Perfusion with 20 mM HCl increased clearance of 51Cr-EDTA four-fold and induced a greater lesion score than did 10 mM. Perfusion with either 10 or 20 mM HCl did not affect the duodenal blood flow. VIP reduced the rise in clearance of 51Cr-EDTA in response to 10 mM but not that to 20 mM HCl. Intravenous injection of prazosin (50 micrograms/kg) decreased luminal alkalinization, clearance of 51Cr-EDTA, blood pressure, and duodenal blood flow. In prazosin-pretreated rats, perfusion with 10 mM HCl increased clearance of 51Cr-EDTA 2.6-fold, and the lesion score was greater in this group than in animals infused with VIP. A positive linear correlation was obtained between HCO3- secretion and the mean rate of H+ disappearance.(ABSTRACT TRUNCATED AT 250 WORDS)

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