Severe skin necrosis following warfarin therapy in a patient with protein C deficiency

1993 ◽  
Vol 233 (3) ◽  
pp. 287-289 ◽  
Author(s):  
H. LOCHT ◽  
F. D. LINDSTRÖM
Keyword(s):  
Skin Necrosis ◽  
Protein C ◽  
Warfarin Therapy ◽  
Protein C Deficiency

scholarly journals Sepsis as a cause of acquired Protein C and Protein S deficiency- A case report and literature review

2014 ◽  
Vol 52 (193) ◽  
pp. 729-731
Author(s):  
Arun Kannan ◽  
Jose Lizcano ◽  
Sweta Chandra ◽  
Christie Murphy
Keyword(s):  
Septic Shock ◽  
Skin Necrosis ◽  
Protein C ◽  
Warfarin Therapy ◽  
Protein S ◽  
Protein S Deficiency ◽  
Protein C Deficiency ◽  
Goal Directed Therapy ◽  
S Deficiency ◽  
Anti Phospholipid Syndrome

Warfarin Induced Skin Necrosis is a well-known complication in patients being started on warfarin without adequate bridging . The mechanism is thought to be due to protein C deficiency . We present a rather unusual cause of protein C deficiency due to sepsis resulting in warfarin induced skin necrosis. 43 year old lady who has been on chronic warfarin therapy secondary to anti phospholipid syndrome was admitted to the hospital for acute ischemic cerebellar stroke. Warfarin was held due to acute thrombocytopenia. She was discharged after restarting the warfarin. She presented back with septic shock due to pneumonia. She was found to have multiple necrotic areas consistent with skin necrosis. Unfortunately, patient died due to multi organ failure despite goal directed therapy. This case demonstrates the importance of recognizing the sepsis as an acquired cause of protein C deficiency.

Homozygous protein C deficiency with late onset and recurrent coumarin-induced skin necrosis

The Lancet ◽  
1992 ◽  
Vol 339 (8795) ◽  
pp. 743-744 ◽  
Author(s):  
J. Conard ◽  
M.H. Horellou ◽  
P. Van Dreden ◽  
M. Samama ◽  
P.H. Reitsma ◽  
...  
Keyword(s):  
Skin Necrosis ◽  
Protein C ◽  
Late Onset ◽  
Protein C Deficiency

Childhood-onset skin necrosis resulting from protein C deficiency

2006 ◽  
Vol 0 (0) ◽  
pp. 070209222700073-???
Author(s):  
PR Criado ◽  
IM Bernardelli ◽  
EA Rivitti ◽  
MN Sotto ◽  
MAC Vilella ◽  
...  
Keyword(s):  
Skin Necrosis ◽  
Protein C ◽  
Childhood Onset ◽  
Protein C Deficiency

scholarly journals NECROSE CUTANEE REVELANT UN DEFICIT CONGENITAL EN PROTEINE C : A PROPOS DE 3 CAS

2021 ◽  
Vol 9 (03) ◽  
pp. 80-83
Author(s):  
S. Halouani ◽  
◽  
W. Kojmane ◽  
F. Hmami ◽  
S. Atmani ◽  
...  
Keyword(s):  
Early Diagnosis ◽  
Replacement Therapy ◽  
Disseminated Intravascular Coagulation ◽  
Skin Necrosis ◽  
Protein C ◽  
Autosomal Recessive ◽  
Autosomal Recessive Disorder ◽  
Protein C Deficiency ◽  
Neonatal Skin ◽  
Protein C Activity

Neonatal skin necrosis in the context of a congenital homozygous protein C deficiency is a rare inherited autosomal recessive disorder, it is characterized by rapidly extensive necrotic patches occurring a few hours after birth in a newborn who doesnt present any hemodynamic disorder. The diagnosis is based on the assay of protein C activity which is collapsed or even undetectable. Early diagnosis and replacement therapy are the mainstays of management before the onset of disseminated intravascular coagulation. We report three cases of newborns presenting with DIC in the context of protein C deficiency and the course of which was fatal.

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