Expressional screening of interferon-stimulated genes for antiviral activity against hepatitis C virus replication

2006 ◽  
Vol 13 (10) ◽  
pp. 690-700 ◽  
Author(s):  
Y. Itsui ◽  
N. Sakamoto ◽  
M. Kurosaki ◽  
N. Kanazawa ◽  
Y. Tanabe ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Antiviral Activity ◽  
Virus Replication ◽  
Interferon Stimulated Genes

scholarly journals Ribavirin Regulates Hepatitis C Virus Replication Through Enhancing Interferon-Stimulated Genes and Interleukin 8

2012 ◽  
Vol 205 (7) ◽  
pp. 1121-1130 ◽  
Author(s):  
Yoshio Tokumoto ◽  
Yoichi Hiasa ◽  
Kazuhiro Uesugi ◽  
Takao Watanabe ◽  
Toshie Mashiba ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Replication ◽  
Interleukin 8 ◽  
Interferon Stimulated Genes

The Design, Synthesis, and Antiviral Activity of 4′-Azidocytidine Analogues against Hepatitis C Virus Replication: The Discovery of 4′-Azidoarabinocytidine

2009 ◽  
Vol 52 (1) ◽  
pp. 219-223 ◽  
Author(s):  
David B. Smith ◽  
Genadiy Kalayanov ◽  
Christian Sund ◽  
Anna Winqvist ◽  
Pedro Pinho ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Antiviral Activity ◽  
Virus Replication ◽  
Design Synthesis

Ferrocene-based inhibitors of hepatitis C virus replication that target NS5A with low picomolar in vitro antiviral activity

2018 ◽  
Vol 28 (21) ◽  
pp. 3463-3471 ◽  
Author(s):  
Venkat R. Gadhachanda ◽  
Kyle J. Eastman ◽  
Qiuping Wang ◽  
Avinash S. Phadke ◽  
Dharaben Patel ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Antiviral Activity ◽  
Virus Replication

scholarly journals Interleukin-1 Inhibits Hepatitis C Virus Subgenomic RNA Replication by Activation of Extracellular Regulated Kinase Pathway

2003 ◽  
Vol 77 (9) ◽  
pp. 5493-5498 ◽  
Author(s):  
Haizhen Zhu ◽  
Chen Liu
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Antiviral Activity ◽  
Interleukin 1 ◽  
Rna Replication ◽  
Inhibitory Effect ◽  
Chronic Infections ◽  
Subgenomic Replicon ◽  
Subgenomic Rna ◽  
Interferon Stimulated Genes

ABSTRACT Interleukin-1 (IL-1) plays an important role in the inflammatory process. Some studies have demonstrated that IL-1 production was impaired in patients with chronic infections of hepatitis C virus (HCV), implying that IL-1 may play a role in viral clearance. Using an HCV subgenomic replicon cell line, we demonstrate that IL-1 can effectively inhibit HCV subgenomic RNA replication and viral protein expression, suggesting that IL-1 has direct antiviral activity. The inhibitory effect is associated with the extracellular regulatory kinase (ERK) activation. In addition, we also show that IL-1 can induce one of the interferon-stimulated genes (ISGs), 1-8U, which exhibits antiviral activity. However, it has no effect on the other ISG, 6-16, suggesting that IL-1 induces novel antiviral pathways within a cell.

Design, Synthesis, and Antiviral Activity of 2‘-Deoxy-2‘-fluoro-2‘-C-methylcytidine, a Potent Inhibitor of Hepatitis C Virus Replication

2005 ◽  
Vol 48 (17) ◽  
pp. 5504-5508 ◽  
Author(s):  
Jeremy L. Clark ◽  
Laurent Hollecker ◽  
J. Christian Mason ◽  
Lieven J. Stuyver ◽  
Phillip M. Tharnish ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Antiviral Activity ◽  
Virus Replication ◽  
Potent Inhibitor ◽  
Design Synthesis

Mechanistic dynamics of Hepatitis C virus replication in single liver cells

2013 ◽  
Vol 51 (01) ◽  
Author(s):  
MM Knodel ◽  
P Targett-Adams ◽  
A Grillo ◽  
S Reiter ◽  
E Herrmann ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Replication ◽  
Liver Cells

Role of autophagy in hepatitis C virus replication

2019 ◽  
Author(s):  
WI Twu ◽  
K Tabata ◽  
D Paul ◽  
R Bartenschlager
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Replication
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