scholarly journals Hepatitis C virus core protein binding to lipid membranes: the role of domains 1 and 2

2008 ◽  
Vol 15 (5) ◽  
pp. 346-356 ◽  
Author(s):  
A. J. Pérez-Berná ◽  
A. S. Veiga ◽  
M. A. R. B. Castanho ◽  
J. Villalaín
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Protein Binding ◽  
Lipid Membranes ◽  
Core Protein ◽  
Virus Core

scholarly journals Role of Hepatitis C virus core protein in viral-induced mitochondrial dysfunction

2009 ◽  
Vol 17 (11) ◽  
pp. 784-793 ◽  
Author(s):  
T. Wang ◽  
R. V. Campbell ◽  
M. K. Yi ◽  
S. M. Lemon ◽  
S. A. Weinman
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Mitochondrial Dysfunction ◽  
Core Protein ◽  
Virus Core

scholarly journals Up-regulating effect of human hepatitis C virus core protein-binding protein 6 on NACA gene promoter

2003 ◽  
Vol 11 (7) ◽  
pp. 959-962 ◽  
Author(s):  
Qian Yang ◽  
Yan Liu ◽  
Jun Cheng ◽  
Ke Li ◽  
Jian-Jun Wang ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Protein Binding ◽  
Core Protein ◽  
Binding Protein ◽  
Gene Promoter ◽  
Virus Core ◽  
Human Hepatitis

scholarly journals Screen for human single chain variable region in antibody against human hepatitis C virus core protein binding protein 6

2003 ◽  
Vol 11 (4) ◽  
pp. 389-393
Author(s):  
Yan-Wei Zhong ◽  
Jun Cheng ◽  
Zhong-Dong Zhang ◽  
Min Sun ◽  
Qiang Li ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Protein Binding ◽  
Core Protein ◽  
Binding Protein ◽  
Variable Region ◽  
Single Chain ◽  
Virus Core ◽  
Human Hepatitis

Distinct functional role of Hepatitis C virus core protein on NF-κB regulation is linked to genomic variation

2002 ◽  
Vol 87 (1) ◽  
pp. 21-29 ◽  
Author(s):  
Ratna B Ray ◽  
Robert Steele ◽  
Arnab Basu ◽  
Keith Meyer ◽  
Mainak Majumder ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Functional Role ◽  
Core Protein ◽  
Genomic Variation ◽  
Virus Core

scholarly journals Peptide inhibitors of hepatitis C virus core oligomerization and virus production

2009 ◽  
Vol 90 (6) ◽  
pp. 1319-1328 ◽  
Author(s):  
S. Kota ◽  
C. Coito ◽  
G. Mousseau ◽  
J.-P. Lavergne ◽  
A. D. Strosberg
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Core Protein ◽  
Virus Production ◽  
Peptide Inhibitors ◽  
Rt Pcr ◽  
Protein Protein Interaction ◽  
Virus Core ◽  
Infected Cells

Hepatitis C virus (HCV) nucleocapsid assembly requires dimerization of the core protein, an essential step in the formation of the virus particle. We developed a novel quantitative assay for monitoring this protein–protein interaction, with the goal of identifying inhibitors of core dimerization that might block HCV production in infected Huh-7.5 hepatoma cells. Two core-derived, 18-residue peptides were found that inhibited the dimerization of a fragment of core comprising residues 1–106 (core106) by 68 and 63 %, respectively. A third, related 15-residue peptide displayed 50 % inhibition, with an IC50 of 21.9 μM. This peptide was shown, by fluorescence polarization, to bind directly to core106 with a K d of 1.9 μM and was displaced by the unlabelled peptide with an IC50 of 18.7 μM. When measured by surface plasmon resonance, the same peptide bound core169 with a K d of 7.2 μM. When added to HCV-infected cells, each of the three peptides blocked release, but not replication, of infectious virus. When measured by real-time RT-PCR, the RNA levels were reduced by 7-fold. The 15-residue peptide had no effect on HIV propagation. Such inhibitors may constitute useful tools to investigate the role of core dimerization in the virus cycle.

Identification of a novel protein binding to hepatitis C virus core protein

2009 ◽  
Vol 24 (7) ◽  
pp. 1300-1304 ◽  
Author(s):  
Yun-ru Chen ◽  
Tian-yan Chen ◽  
Shu-lin Zhang ◽  
Shu-mei Lin ◽  
Ying-ren Zhao ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Protein Binding ◽  
Core Protein ◽  
Virus Core ◽  
Novel Protein

Role of Hepatitis C Virus Core Antigen Assay in Blood Donors Screening at Zagazig University Hospitals

2018 ◽  
Vol 8 (1) ◽  
pp. 48-54
Author(s):  
Rashed Hassan ◽  
Abdelmonem Elshamy ◽  
Sameh Abdel Monem ◽  
Emad Moustafa ◽  
Essam Wahab
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Blood Donors ◽  
Core Antigen ◽  
University Hospitals ◽  
Virus Core ◽  
Antigen Assay

Biosynthesis and biochemical properties of the hepatitis C virus core protein.

1994 ◽  
Vol 68 (6) ◽  
pp. 3631-3641 ◽  
Author(s):  
E Santolini ◽  
G Migliaccio ◽  
N La Monica
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Core Protein ◽  
Biochemical Properties ◽  
Virus Core
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