Scintigraphic validation of AC Biosusceptometry to study the gastric motor activity and the intragastric distribution of food in humans

In a double-blind trial, 12 out-patients with primary anorexia nervosa received, for six weeks, either 10 mg cisapride or placebo, three times a day. Cisapride accelerated gastric emptying of a radiolabelled semisolid meal in all six patients; five gained weight and symptoms of gastric retention ameliorated in four. With placebo, three of six had emptying enhanced, four gained weight, and one's symptoms improved. For another six weeks, all patients received cisapride. In five of the patients who had received cisapride, emptying further accelerated or remained stable; in one it slowed. Of the six patients who received placebo, four had emptying accelerated, five gained weight, and symptoms improved in four. Longer administration of cisapride may, by enhancing gastric motor activity, alleviate symptoms of retention and thus help to change eating behaviour.

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Effect of Gastrin on Gastric Motor Activity

Gastroenterology ◽

10.1016/s0016-5085(19)33820-x ◽

1969 ◽

Vol 57 (6) ◽

pp. 649-658 ◽

Cited By ~ 8

Author(s):

Kyoji Sugawara ◽

Jaime Isaza ◽

E.R. Woodward

Keyword(s):

Motor Activity ◽

Gastric Motor Activity

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Convergence of inhibitory neural inputs regulate motor activity in the murine and monkey stomach

AJP Gastrointestinal and Liver Physiology ◽

10.1152/ajpgi.00062.2016 ◽

2016 ◽

Vol 311 (5) ◽

pp. G838-G851 ◽

Cited By ~ 4

Author(s):

Lara A. Shaylor ◽

Sung Jin Hwang ◽

Kenton M. Sanders ◽

Sean M. Ward

Keyword(s):

Nitric Oxide ◽

Motor Activity ◽

Motor Neurons ◽

Electrical Field Stimulation ◽

Neural Responses ◽

Motor Patterns ◽

Primate Model ◽

Distal Stomach ◽

Gastric Motor Activity ◽

Motor Nerves

Inhibitory motor neurons regulate several gastric motility patterns including receptive relaxation, gastric peristaltic motor patterns, and pyloric sphincter opening. Nitric oxide (NO) and purines have been identified as likely candidates that mediate inhibitory neural responses. However, the contribution from each neurotransmitter has received little attention in the distal stomach. The aims of this study were to identify the roles played by NO and purines in inhibitory motor responses in the antrums of mice and monkeys. By using wild-type mice and mutants with genetically deleted neural nitric oxide synthase ( Nos1 −/−) and P2Y1 receptors ( P2ry1 −/−) we examined the roles of NO and purines in postjunctional inhibitory responses in the distal stomach and compared these responses to those in primate stomach. Activation of inhibitory motor nerves using electrical field stimulation (EFS) produced frequency-dependent inhibitory junction potentials (IJPs) that produced muscle relaxations in both species. Stimulation of inhibitory nerves during slow waves terminated pacemaker events and associated contractions. In Nos1 −/− mice IJPs and relaxations persisted whereas in P2ry1 −/− mice IJPs were absent but relaxations persisted. In the gastric antrum of the non-human primate model Macaca fascicularis, similar NO and purine neural components contributed to inhibition of gastric motor activity. These data support a role of convergent inhibitory neural responses in the regulation of gastric motor activity across diverse species.

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