PENGARUH SPA BAYI TERHADAP PENINGKATAN BERAT BADAN BAYI USIA 4-6 BULAN DI WILAYAH KERJA PUSKESMAS TAPIAN DOLOK KABUPATEN SIMALUNGUN

Infan is the period as well as the time of Christ's development. It is said to be a critical period because this period is very short for the environment and it is said to be a development period because infancy is not very short and can be repeated again. The most important period of child development is infancy and toddlerhood. In infancy / toddler there is a basic growth that will determine the next child's development. Infancy is the first month of life, the baby will adapt to the environment, changes in blood circulation, and begin to work the organs of the body, and in post-neonatal the baby will experience very fast growth. One way to stimulate growth and development in children is to use the baby solus per aqua (SPA) technique. Babies who are given SPA Babies will certainly grow and develop differently from the growth and development of babies who are not given SPA Babies. This is because the Baby SPA series aims to awaken the baby's sensory and motor nerves early with certain stimuli so that babies can grow actively and be more optimal both physically and mentally. This study aims to obtain an overview of the effect of Infant SPA on weight gain aged 4 to 6 months, Measuring the weight gain of infants aged 4 to 6 months who receive and Infant SPA and those who do not receive massage and Infant SPA at the Tapian Dolok Health Center, Simalungun Regency. The hypothesis in this study is that the increase in the weight of the babies who received the Baby Spa was greater than the standard deviation of the weight gain of 36.9 with a mean difference of 48.7 grams between the two groups. The sample size obtained is 12 respondents so that the number of samples will be increased to 30 according to the minimum sample that can be analyzed statistically. So the intervention group was 30 babies and the control group was 30 babies. The results showed that there was an effect of SPA for infants on weight gain of infants at the age of 4 to 6 months. This study is expected to provide knowledge to mothers who have babies aged 4 6 months the importance of SPA for babies to the baby's weight gain.

Overview of Motor Nerve Damage in People with Diabetes Mellitus

Damage to motor nerves in people with diabetes increases the risk of a foot injury. This occurs because the damage results in changes in foot biomechanics, muscle atrophy, deformity, and increased pressure on the feet. So far, the examination of motor nerve damage in people with diabetes in agricultural areas such as the Jember Regency is still rarely touched by primary health services. The purpose of this study was to identify motor nerve damage in people with diabetes in the agriculture area of ​​the Jember Regency. This type of research is exploratory, descriptive, 102 respondents obtained by purposive sampling technique. Inclusion criteria in this study are age> 18 years; do not have DFU active, and did not experience amputation in both legs. Data collection uses instrument modification from MNSI (Michigan Neuropathy Screening Instrument) and MDNS (Michigan Diabetic Neuropathy Score). MNSI using in inspecting for deformity, while MDNS using for forms of physiological reflex damage and muscle strength. The analysis used in univariate and displayed in the frequency distribution. The results showed that the majority of respondents who suffer from DM are experienced in the middle adulthood category (71.6%), with a length of suffering more than five years (95.1%), and have a history of comorbidities (68.6%). The most common form of motor deformity damage was hallux valgus on the right and left legs (38.2%; 26.4%). Forms of motor damage in the form of muscle strength, severe damage to the abduction of the right and left legs (7.8%), and were found right or left toe extensions (1.9%; 2.9%). Motor damage in the form of no physiological reflexes was found in the right and left Quadriceps femoral (2%; 1%), and right or left leg Achilles (1%). The result of total motor damage assessment is that people with diabetes have decreased muscle strength in the right and left extremities (74.5%; 72.5%). This research shows that the majority of people with diabetes in the agricultur area of ​​the Jember Regency suffer motor nerve damage. Therefore, there is a need for preventive measures to prevent the worsening condition of people with diabetes.

Application of Microspectral Imaging in Motor and Sensory Nerve Classification

Objective. It aimed to explore the application of the microscopic hyperspectral technique in motor and sensory nerve classification. Methods. The self-developed microscopic hyperspectral acquisition system was applied to collect the data of anterior and posterior spinal cord sections of white rabbits. The joint correction algorithm was employed to preprocess the collected data, such as noise reduction. On the basis of pure linear light source index, a new pixel purification algorithm based on cross contrast was proposed to extract more regions of interest, which was used for feature extraction of motor and sensory nerves. Besides, the ML algorithm was employed to classify motor and sensory nerves based on feature extraction results. Results. The joint correction algorithm was adopted to preprocess the data collected by the microscopic hyperspectral technique, so as to eliminate the influence of the incident light source and the system and improve the classification accuracy. The axon and myelin spectrum curves of the two kinds of nerves in the stained specimens had the same trend, but the values of all kinds of spectrum of sensory nerves were higher than those of motor nerves. However, the myelin sheath spectrum curves of motor nerves in the unstained specimens were greatly different from the curves of sensory nerves. The axon spectrum curves had the same trend, but the axon spectrum values of sensory nerves were higher than those of motor nerves. The ML algorithm had high accuracy and fast speed in motor and sensory nerve classification, and the classification effect of stained specimens was better than that of unstained specimens. Conclusion. The microscopic hyperspectral technique had high feasibility in sensory and motor nerve classification and was worthy of further research and promotion.

Cryotherapy for Prevention of Taxane-Induced Peripheral Neuropathy: A Meta-Analysis

PurposeTaxanes are widely used in gynecological cancer therapy, however, taxane-induced peripheral neuropathy (TIPN) limits chemotherapy dose and reduces patients’ quality of life. As a safe and convenient intervention, cryotherapy has been recommended as a promising intervention in the recent clinical guidelines for the prevention of TIPN. Although there are a considerable number of studies which explored the use of cryotherapy in preventing chemotherapy-induced peripheral neuropathy (CIPN), there is insufficient large-scale clinical evidence. We performed a meta-analysis on the current available evidence to examine whether cryotherapy can prevent TIPN in cancer patients receiving taxanes.MethodsWe searched databases including PubMed, Embase, and Cochrane from inception to August 3, 2021 for eligible trials. Clinical trials that examined the efficacy of cryotherapy for prevention of TIPN were included. The primary outcome was the incidence of TIPN, and secondary outcomes were incidence of taxane dose reduction and changes in nerve conduction studies. The meta-analysis software (RevMan 5.3) was used to analyze the data.ResultsWe analyzed 2250 patients from 9 trials. Assessments using the Common Terminology Criteria for Adverse Events (CTCAE) score showed that cryotherapy could significantly reduce the incidence of motor and sensory neuropathy of grade≥2 (sensory: RR 0.65, 95%CI 0.56 to 0.75, p<0.00001; motor: RR 0.18, 95% CI [0.03, 0.94], p=0.04). When evaluated using the Patient Neuropathy Questionnaire (PNQ), cryotherapy demonstrated significant reduction in the incidence of sensory neuropathy (RR 0.11, 95% CI 0.04 to 0.31], p<0.0001), but did not show significant reduction in the incidence of motor neuropathy (RR 0.46, 95% CI 0.11 to 1.88, p=0.28). Cryotherapy was associated with reduced incidences of taxane dose reduction due to TIPN (RR 0.48, 95% CI [0.24, 0.95], p=0.04) and had potential to preserve motor nerves.ConclusionsCryotherapy is likely to prevent TIPN in patients receiving taxanes. High quality and sufficient amount of evidence is warranted.

Denervation of the Wrist Joint and Its Long Term Effect

Background The wrist joint is a common site of traumatic, degenerative and inflammatory disease that, when symptoms are severe, can be treated by partial or complete arthrodesis, arthroplasty and/or wrist denervation. Aim of the Work to review systematically studies about total and partial wrist denervation for chronic painful wrist conditions and meta-analyze the long term improvement. Materials and Methods Literature searches was conducted using the following databases: "PubMed, Ovid, Web of Science, Science Direct, Scopus, Cochrane Library, Google Scholar, Medline" using the following key words: wrist joint, total denervation, partial denervation for published studies. Results This study provides long-term data regarding the outcomes of partial and total wrist denervation. We have found that this is a reliable motion preserving procedure for patients with chronic wrist pain. In the series, 85% and 70% of patients did not undergo revision surgery at average follow-up of approximately 54.7 months and 47.5 months in total and partial denervation respectively. Conclusion Denervation is a relatively quick procedure with low complication rates and does not preclude salvage procedures if pain persists. It has been shown that neurectomy of the articular branches is possible without any injury to the important sensory and motor nerves of the hand. Total denervation of the wrist is a useful method for treating wrist pain when other choices compromise functional capacity or a long period of post-operative recovery is not desired.

Permainan Tradisional Sebagai Sarana Mengembangkan Kemampuan Fisik Motorik Anak dan Nilai-Nilai Pendidikan Islam di PAUD Kamboja Probolinggo

The goal of this research was to examine how traditional games can help Cambodian Probolinggo PAUD kids improve gross motor abilities while also teaching Islamic values. To address important issues, the author employs qualitative research methods such as observation, documentation, and interviews to gather data. In addition, data triangulation will be used to evaluate the information gathered (sources and techniques). One of the most important parts of an individual's total development is physical motor development. Traditional games have been shown to benefit children's gross motor nerves by requiring them to use their physical abilities in order to play. Traditional games can also be used as cultural heritage because people recognize that they are original games passed down from their forefathers and that they must be conserved so that they do not become extinct and forgotten. Traditional games help Cambodian Probolinggo PAUD children learn Islamic educational ideals. When the youngsters are at home, religious adherence and honesty are also indicators. Penelitian ini bertujuan untuk mengkaji bagaimana permainan tradisional dapat membantu anak PAUD Kamboja Probolinggo meningkatkan kemampuan motorik kasar sekaligus mengajarkan nilai-nilai Islam. Untuk mengatasi masalah penting, penulis menggunakan metode penelitian kualitatif seperti observasi, dokumentasi, dan wawancara untuk mengumpulkan data. Selain itu, triangulasi data akan digunakan untuk mengevaluasi informasi yang dikumpulkan (sumber dan teknik). Salah satu bagian terpenting dari perkembangan total individu adalah perkembangan motorik fisik. Permainan tradisional telah terbukti bermanfaat bagi saraf motorik kasar anak-anak dengan mengharuskan mereka menggunakan kemampuan fisik mereka untuk bermain. Permainan tradisional juga dapat dijadikan sebagai warisan budaya karena masyarakat mengakui bahwa permainan tersebut merupakan permainan asli yang diturunkan dari nenek moyang dan harus dilestarikan agar tidak punah dan terlupakan. Permainan tradisional membantu anak-anak PAUD Kamboja Probolinggo mempelajari cita-cita pendidikan Islam. Ketika anak-anak berada di rumah, sinyalnya sama-sama religius dan jujur.

KATP channels and NO dilate redundantly intramuscular arterioles during electrical stimulation of the skeletal muscle in mice

Functional hyperemia is fundamental to provide enhanced oxygen delivery during exercise in skeletal muscle. Different mechanisms are suggested to contribute, mediators from skeletal muscle, transmitter spillover from the neuromuscular synapse as well as endothelium-related dilators. We hypothesized that redundant mechanisms that invoke adenosine, endothelial autacoids, and KATP channels mediate the dilation of intramuscular arterioles in mice. Arterioles (maximal diameter: 20–42 µm, n = 65) were studied in the cremaster by intravital microscopy during electrical stimulation of the motor nerve to induce twitch or tetanic skeletal muscle contractions (10 or 100 Hz). Stimulation for 1–60 s dilated arterioles rapidly up to 65% of dilator capacity. Blockade of nicotinergic receptors blocked muscle contraction and arteriolar dilation. Exclusive blockade of adenosine receptors (1,3-dipropyl-8-(p-sulfophenyl)xanthine) or of NO and prostaglandins (nitro-L-arginine and indomethacin, LN + Indo) exerted only a minor attenuation. Combination of these blockers, however, reduced the dilation by roughly one-third during longer stimulation periods (> 1 s at 100 Hz). Blockade of KATP channels (glibenclamide) which strongly reduced adenosine-induced dilation reduced responses upon electrical stimulation only moderately. The attenuation was strongly enhanced if glibenclamide was combined with LN + Indo and even observed during brief stimulation. LN was more efficient than indomethacin to abrogate dilations if combined with glibenclamide. Arteriolar dilations induced by electrical stimulation of motor nerves require muscular contractions and are not elicited by acetylcholine spillover from neuromuscular synapses. The dilations are mediated by redundant mechanisms, mainly activation of KATP channels and release of NO. The contribution of K+ channels and hyperpolarization sets the stage for ascending dilations that are crucial for a coordinated response in the network.

To the clinic of epidemic hiccups

In wide medical circles, persistent hiccups, singultus are viewed either as a highly serious symptom of a severe disease of the abdominal organs or the central nervous system, or as an accidental reflex to the motor nerves of the diaphragm that is not of great importance for patients and the muscles of the chest and abdomen.

Perturbed BMP signaling and denervation promote muscle wasting in cancer cachexia

Most patients with advanced solid cancers exhibit features of cachexia, a debilitating syndrome characterized by progressive loss of skeletal muscle mass and strength. Because the underlying mechanisms of this multifactorial syndrome are incompletely defined, effective therapeutics have yet to be developed. Here, we show that diminished bone morphogenetic protein (BMP) signaling is observed early in the onset of skeletal muscle wasting associated with cancer cachexia in mouse models and in patients with cancer. Cancer-mediated factors including Activin A and IL-6 trigger the expression of the BMP inhibitor Noggin in muscle, which blocks the actions of BMPs on muscle fibers and motor nerves, subsequently causing disruption of the neuromuscular junction (NMJ), denervation, and muscle wasting. Increasing BMP signaling in the muscles of tumor-bearing mice by gene delivery or pharmacological means can prevent muscle wasting and preserve measures of NMJ function. The data identify perturbed BMP signaling and denervation of muscle fibers as important pathogenic mechanisms of muscle wasting associated with tumor growth. Collectively, these findings present interventions that promote BMP-mediated signaling as an attractive strategy to counteract the loss of functional musculature in patients with cancer.