An Experimental Model in Mink for Studying the Relation Between Amyloid Fibril Protein AA and the Related Serum Protein, SAA

1975 ◽  
Vol 4 (7) ◽  
pp. 811-816 ◽  
Author(s):  
G. HUSBY ◽  
J. B. NATVIG ◽  
K. SLETTEN ◽  
K. NORDSTOGA ◽  
R. F. ANDERS
1976 ◽  
Vol 143 (3) ◽  
pp. 678-683 ◽  
Author(s):  
R F Anders ◽  
K Nordstoga ◽  
J B Natvig ◽  
G Husby

The concentration of the amyloid AA-related serum protein (SAA) was markedly increased after endotoxin injections in mink, mouse, rabbit, and man. It was particularly studied during the development of endotoxin-induced amyloidosis of the mink. Protein SAA was markedly elevated in all mink 24 h after the first endotoxin injection but had fallen to relatively low levels before the onset of amyloidosis at about 4 wk. These results are consistent with SAA being a circulating precursor of the amyloid fibril protein, AA. However, both proteins may be derived by proteolysis from a common precursor.


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