Immunoglobulin E and Immunoglobulin G4 Antibodies to Cow's Milk in Children with Cow's Milk Allergy

Objective Cow’s milk allergy is the most common food allergy in childhood. Changes occur in the protein structure of milk during yogurt fermentation. This study aimed to determine whether children who are diagnosed with a cow’s milk allergy can tolerate yogurt. Methods We performed a yogurt challenge test on 34 children who were diagnosed with a cow’s milk allergy in our Pediatric Allergy Outpatient Clinic. The mean age of 24 male and 10 female children was 24 ± 13 months. Results A reaction was observed in 17 (50%) patients, whereas no reaction was observed in the other 17 (50%) during an oral yogurt challenge test that was performed in all of the 34 patients with a cow’s milk allergy. Cow’s milk-specific immunoglobulin E levels were significantly lower in the group of children who could tolerate yogurt than in the group of children who could not tolerate yogurt. Conclusion Yogurt is tolerated by half of children with a cow’s milk allergy when subjected to a challenge test performed with yogurt, which is consumed as much as milk in Turkey.

Download Full-text

Open oral food challenge in the confirmation of cow's milk allergy mediated by immunoglobulin E

Allergologia et Immunopathologia ◽

10.1016/j.aller.2011.02.007 ◽

2012 ◽

Vol 40 (1) ◽

pp. 25-30 ◽

Cited By ~ 5

Author(s):

R. Bicudo Mendonça ◽

J. Motta Franco ◽

R. Rodrigues Cocco ◽

F.I. Suano de Souza ◽

L.C. Lopes de Oliveira ◽

...

Keyword(s):

Immunoglobulin E ◽

Food Challenge ◽

Oral Food Challenge ◽

Cow’S Milk Allergy ◽

Cow’S Milk ◽

Milk Allergy ◽

Cow's Milk ◽

Cow's Milk Allergy

Download Full-text

Epidemiology of Cow’s Milk Allergy

Nutrients ◽

10.3390/nu11051051 ◽

2019 ◽

Vol 11 (5) ◽

pp. 1051 ◽

Cited By ~ 21

Author(s):

Julie D. Flom ◽

Scott H. Sicherer

Keyword(s):

Natural History ◽

Immunoglobulin E ◽

Cow’S Milk Allergy ◽

Food Allergies ◽

Cow’S Milk ◽

Milk Allergy ◽

Cow's Milk ◽

Cow's Milk Allergy ◽

Immune Mediated

Immunoglobulin E (IgE)-mediated cow’s milk allergy (CMA) is one of the most common food allergies in infants and young children. CMA can result in anaphylactic reactions, and has long term implications on growth and nutrition. There are several studies in diverse populations assessing the epidemiology of CMA. However, assessment is complicated by the presence of other immune-mediated reactions to cow’s milk. These include non-IgE and mixed (IgE and non-IgE) reactions and common non-immune mediated reactions, such as lactose intolerance. Estimates of prevalence and population-level patterns are further complicated by the natural history of CMA (given its relatively high rate of resolution) and variation in phenotype (with a large proportion of patients able to tolerate baked cow’s milk). Prevalence, natural history, demographic patterns, and long-term outcomes of CMA have been explored in several disparate populations over the past 30 to 40 years, with differences seen based on the method of outcome assessment, study population, time period, and geographic region. The primary aim of this review is to describe the epidemiology of CMA. The review also briefly discusses topics related to prevalence studies and specific implications of CMA, including severity, natural course, nutritional impact, and risk factors.

Download Full-text