Electrophysiological evidence for an antinociceptive effect of ketamine in the rat spinal cord

1998 ◽  
Vol 42 (4) ◽  
pp. 435-441 ◽  
Author(s):  
J.-X. Hao ◽  
B. H. Sjölund ◽  
Z. Wiesenfeld-Hallin
Keyword(s):  
Spinal Cord ◽  
Antinociceptive Effect ◽  
Rat Spinal Cord ◽  
Electrophysiological Evidence

scholarly journals Antinociceptive Effect and Enzymatic Degradation of Endomorphin-1 in Newborn Rat Spinal Cord

1999 ◽  
Vol 81 (3) ◽  
pp. 264-270
Author(s):  
Azusa Sugimoto-Watanabe ◽  
Kazufumi Kubota ◽  
Kenji Fujibayashi ◽  
Koji Saito
Keyword(s):  
Spinal Cord ◽  
Enzymatic Degradation ◽  
Antinociceptive Effect ◽  
Rat Spinal Cord ◽  
Newborn Rat

Roles of adenosine receptor subtypes on the antinociceptive effect of sildenafil in rat spinal cord

2010 ◽  
Vol 480 (3) ◽  
pp. 182-185 ◽  
Author(s):  
Hyung Gon Lee ◽  
Woong Mo Kim ◽  
Jeong Il Choi ◽  
Myung Ha Yoon
Keyword(s):  
Spinal Cord ◽  
Adenosine Receptor ◽  
Antinociceptive Effect ◽  
Receptor Subtypes ◽  
Rat Spinal Cord

scholarly journals Antinociceptive effect of selective G protein-gated inwardly rectifying K+ channel agonist ML297 in the rat spinal cord

PLoS ONE ◽  
2020 ◽  
Vol 15 (9) ◽  
pp. e0239094
Author(s):  
Masami Kimura ◽  
Hiroaki Shiokawa ◽  
Yuji Karashima ◽  
Makoto Sumie ◽  
Sumio Hoka ◽  
...  
Keyword(s):  
Spinal Cord ◽  
G Protein ◽  
Antinociceptive Effect ◽  
K Channel ◽  
Rat Spinal Cord ◽  
Inwardly Rectifying ◽  
Channel Agonist

scholarly journals Antinociception Following Implantation of AtT-20 and Genetically Modified AtT-20/hENK Cells in Rat Spinal Cord

1993 ◽  
Vol 4 (1) ◽  
pp. 15-26 ◽  
Author(s):  
Hope H. Wu ◽  
Steven C. McLoon ◽  
George L. Wilcox
Keyword(s):  
Spinal Cord ◽  
Antinociceptive Effect ◽  
Alternative Therapy ◽  
Immunohistochemical Analysis ◽  
Opioid Antagonist ◽  
Control Group ◽  
Tail Flick ◽  
Rat Spinal Cord ◽  
Adrenergic Agonist ◽  
Spinal Subarachnoid Space

AtT-20 cells, which produceß-endorphin, and AtT-20/hENK cells, which are AtT-20 cells transfected with a proenkephalin gene, were implanted in the rat spinal subarachnoid space in an effort to produce an antinociceptive effect. Host rats were tested for antinociceptive activity by standard nociceptive tests, tail flick and hot plate. Although cell implants had minimal effect on the basal response to thermal nociceptive stimuli, administration of theß2-adrenergic agonist isoproterenol produced antinociception in the cell-implanted group but not in the control group. The antinociceptive effect of isoproterenol was dose-related and could be blocked by the opioid antagonist naloxone. Immunohistochemical analysis of spinal cords revealed the presence of enkephalin-negative cells surrounding the spinal cord of rats receiving AtT-20 cell implants, and enkephalinpositive cells surrounding the spinal cord of rats. receiving AtT-20/hENK cell implants. These results suggest that opioid-releasing cells implanted around rat spinal cord can produce antinociception and may provide an alternative therapy for chronic pain.

Immunohistochemical determination of rat spinal cord substance P, and antinociceptive effect during development of thiamine deficiency

1995 ◽  
Vol 696 (1-2) ◽  
pp. 21-29 ◽  
Author(s):  
Takeshi Tadano ◽  
Takahiro Asao ◽  
Tomoki Aizawa ◽  
Shinobu Sakurada ◽  
Yuji Abe ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Substance P ◽  
Thiamine Deficiency ◽  
Antinociceptive Effect ◽  
Rat Spinal Cord

scholarly journals Antinociceptive Effect and Enzymatic Degradation of Endomorphin-1 in Newborn Rat Spinal Cord.

1999 ◽  
Vol 81 (3) ◽  
pp. 264-270 ◽  
Author(s):  
Azusa Sugimoto-Watanabe ◽  
Kazufumi Kubota ◽  
Kenji Fujibayashi ◽  
Koji Saito
Keyword(s):  
Spinal Cord ◽  
Enzymatic Degradation ◽  
Antinociceptive Effect ◽  
Rat Spinal Cord ◽  
Newborn Rat
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