A Randomized Trial of Solvent/Detergent and Standard Fresh Frozen Plasma in the Treatment of the Coagulopathy seen during Orthotopic Liver Transplantation

Vox Sanguinis ◽  
1998 ◽  
Vol 74 (S1) ◽  
pp. 225-229 ◽  
Author(s):  
J. W. Freeman ◽  
L. M. Williamson ◽  
C. Llewelyn ◽  
N. Fisher ◽  
J. P. Allain ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Randomized Trial ◽  
Orthotopic Liver Transplantation ◽  
Fresh Frozen Plasma ◽  
Fresh Frozen ◽  
Frozen Plasma

A randomized trial of solvent/detergent-treated and standard fresh-frozen plasma in the coagulopathy of liver disease and liver transplantation

Transfusion ◽  
1999 ◽  
Vol 39 (11-12) ◽  
pp. 1227-1234 ◽  
Author(s):  
L.M. Williamson ◽  
C.A. Llewelyn ◽  
N.C. Fisher ◽  
J.P. Allain ◽  
M.C. Bellamy ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Disease ◽  
Randomized Trial ◽  
Fresh Frozen Plasma ◽  
Fresh Frozen ◽  
Frozen Plasma

Liver Transplantation Without the Use of Fresh Frozen Plasma

1996 ◽  
Vol 83 (4) ◽  
pp. 681-686 ◽  
Author(s):  
Jacques Dupont ◽  
Frederic Messiant ◽  
Nicole Declerck ◽  
Benoit Tavernier ◽  
Brigitte Jude ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Fresh Frozen Plasma ◽  
Fresh Frozen ◽  
Frozen Plasma

High-titered anti-HBs fresh frozen plasma for immunoprophylaxis against hepatitis B virus recurrence after liver transplantation

1997 ◽  
Vol 29 (5) ◽  
pp. 2369-2373 ◽  
Author(s):  
G. Mentha ◽  
E. Giostra ◽  
F. Negro ◽  
L. Rubbia-Brandt ◽  
O. Huber ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Fresh Frozen Plasma ◽  
B Virus ◽  
Fresh Frozen ◽  
Frozen Plasma

Liver Transplantation Without the Use of Fresh Frozen Plasma

1996 ◽  
Vol 83 (4) ◽  
pp. 681-686 ◽  
Author(s):  
Jacques Dupont ◽  
Frederic Messiant ◽  
Nicole Declerck ◽  
Benoit Tavernier ◽  
Brigitte Jude ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Fresh Frozen Plasma ◽  
Fresh Frozen ◽  
Frozen Plasma

Liver Transplantation Without the Use of Fresh Frozen Plasma

1997 ◽  
Vol 41 (5) ◽  
pp. 312
Author(s):  
JACQUES DU PONT ◽  
FREDERIC MESSIANT ◽  
NICOLE DECLERCK ◽  
BENOIT TAVERNIER ◽  
BRIGITTE JUDE ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Fresh Frozen Plasma ◽  
Fresh Frozen ◽  
Frozen Plasma

scholarly journals Patterns of Coagulopathy during Liver Transplantation: Experience with the First 75 Cases using Thrombelastography

1994 ◽  
Vol 22 (6) ◽  
pp. 659-665 ◽  
Author(s):  
P. L. Mcnicol ◽  
G. Liu ◽  
I. D. Harley ◽  
P. R. Mccall ◽  
G. M. Przybylowski ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Transplant ◽  
Fresh Frozen Plasma ◽  
Specific Pattern ◽  
Site Assessment ◽  
Early Reperfusion ◽  
Function Test ◽  
Fresh Frozen ◽  
Coagulation Status ◽  
Frozen Plasma

Using both conventional laboratory clotting profile and thrombelastography, coagulation status was monitored intraoperatively during liver transplantation in the first 75 cases performed at the Austin Hospital between June 1988 and October 1992. Superimposed on a baseline coagulopathy due to liver disease is a specific pattern of coagulation disturbance which occurs during a liver transplant. Fibrinolysis occurs in the anhepatic stage, worsens with early reperfusion and then spontaneously resolves. In addition reperfusion is associated with a transient clotting defect. If blood loss is excessive, coagulopathy due to massive transfusion may compound the situation. Thrombelastography is a measurement technique allowing rapid on-site assessment of functional clotting status’. It is particularly useful in liver transplant surgery. In combination with clinical bleeding assessment it facilitates selective use of component therapy (fresh frozen plasma, platelets and cryoprecipitate) and specific drug treatment only when it is appropriate. It also acts as a liver function test, being especially useful in assessing the graft after reperfusion.

Bioscavenger therapy for organophosphate poisoning – an open-labeled pilot randomized trial comparing fresh frozen plasma or albumin with saline in acute organophosphate poisoning in humans

2010 ◽  
Vol 48 (8) ◽  
pp. 813-819 ◽  
Author(s):  
Kishore Pichamuthu ◽  
Jayakumar Jerobin ◽  
Anupama Nair ◽  
George John ◽  
Joseph Kamalesh ◽  
...  
Keyword(s):  
Randomized Trial ◽  
Fresh Frozen Plasma ◽  
Organophosphate Poisoning ◽  
Fresh Frozen ◽  
Frozen Plasma

scholarly journals Blood Loss and Transfusion Requirements in Liver Transplantation: Experience with the First 75 Cases

1994 ◽  
Vol 22 (6) ◽  
pp. 666-671 ◽  
Author(s):  
P. L. Mcnicol ◽  
G. Liu ◽  
I. D. Harley ◽  
P. R. Mccall ◽  
G. M. Przybylowski ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Blood Loss ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Surgical Techniques ◽  
Fresh Frozen Plasma ◽  
Transfusion Requirements ◽  
Fresh Frozen ◽  
The Mean ◽  
Frozen Plasma

The blood loss data and transfusion requirements including blood bank, salvaged washed red cells, fresh frozen plasma and cryoprecipitate were analysed for the first 75 cases of liver transplantation performed at the Austin Hospital between June 1988 and October 1992. The mean blood loss was 8.8 litres (standard deviation 14.1) with a median value of 4.0 litres. Blood product use expressed as mean number of units (SD) was bank red blood cells 7.1 (12.7), washed red blood cells 3.9 (5.9), fresh frozen plasma 7.1 (9.1), platelets 5.1 (7.4), and cryoprecipitate 1.7 (5.1). These results demonstrate that liver transplantation can be performed without imposing excessive demands on blood transfusion services. Management should include surgical techniques to minimize bleeding and use of autologous transfusion. Use of component therapy (FFP, platelets and cryoprecipitate) should not be empirical. It should be selective on the basis of clinical bleeding assessment and guided by results of the laboratory coagulation profile and changes in thrombelastographic (TEG) parameters.

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