Bunina bodies in amyotrophic lateral sclerosis

2008 ◽  
Vol 28 (2) ◽  
pp. 109-115 ◽  
Author(s):  
Koichi Okamoto ◽  
Yuji Mizuno ◽  
Yukio Fujita
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Bunina Bodies ◽  
Lateral Sclerosis

scholarly journals Autophagy Is a Common Degradation Pathway for Bunina Bodies and TDP-43 Inclusions in Amyotrophic Lateral Sclerosis

2019 ◽  
Vol 78 (10) ◽  
pp. 910-921 ◽  
Author(s):  
Fumiaki Mori ◽  
Yasuo Miki ◽  
Tomoya Kon ◽  
Kunikazu Tanji ◽  
Koichi Wakabayashi
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Motor Neurons ◽  
Cathepsin B ◽  
Cathepsin D ◽  
Early Stage ◽  
Degradation Pathway ◽  
Sporadic Amyotrophic Lateral Sclerosis ◽  
Bunina Bodies ◽  
Related Proteins ◽  
Lateral Sclerosis

Abstract Bunina bodies (BBs) coexisting with TDP-43-immunoreactive (TDP-43-IR) skein-like inclusions (SIs) and round inclusions (RIs) in lower motor neurons are a frequent feature of sporadic amyotrophic lateral sclerosis (sALS). Since previous studies have shown that BBs and TDP-43-IR inclusions are often detected in association with autophagy-related structures (autophagosomes and autolysosomes), we examined the anterior horn cells (AHCs) of the spinal cord from 15 patients with sALS and 6 control subjects, using antibodies against autophagy-related proteins (LC3, cathepsin B, and cathepsin D). Among AHCs with SIs, 43.9% contained BBs, whereas 51.7% of AHCs with RIs did so. The cytoplasm of AHCs showed diffuse immunoreactivity for LC3, cathepsin B and cathepsin D in both sALS and controls. Ultrastructurally, SIs and mature BBs contained autophagosomes and autolysosomes. Mature BBs were localized in the vicinity of SIs. RIs also contained autophagosomes, autolysosomes, and early-stage BBs. These findings suggest that autophagy is a common degradation pathway for BBs and TDP-43-IR inclusions, which may explain their frequent coexistence.

The relationship between Bunina bodies, skein-like inclusions and neuronal loss in amyotrophic lateral sclerosis

2002 ◽  
Vol 103 (6) ◽  
pp. 583-589 ◽  
Author(s):  
M. van Welsem ◽  
Hogenhuis J. ◽  
Meininger V. ◽  
Metsaars W. ◽  
Hauw J.-J. ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Neuronal Loss ◽  
Bunina Bodies ◽  
The Relationship ◽  
Lateral Sclerosis

Colocalization of Bunina bodies and TDP-43 inclusions in a case of sporadic amyotrophic lateral sclerosis with Lewy body-like hyaline inclusions

2018 ◽  
Vol 38 (5) ◽  
pp. 521-528 ◽  
Author(s):  
Yasuo Miki ◽  
Fumiaki Mori ◽  
Yusuke Seino ◽  
Kunikazu Tanji ◽  
Tadashi Yoshizawa ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Lewy Body ◽  
Sporadic Amyotrophic Lateral Sclerosis ◽  
Hyaline Inclusions ◽  
Bunina Bodies ◽  
Lateral Sclerosis

Ultrastructure of the Bunina bodies in anterior horn cells of amyotrophic lateral sclerosis

1978 ◽  
Vol 42 (2) ◽  
pp. 81-86 ◽  
Author(s):  
M. Tomonaga ◽  
M. Saito ◽  
M. Yoshimura ◽  
H. Shimada ◽  
H. Tohgi
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Anterior Horn ◽  
Anterior Horn Cells ◽  
Bunina Bodies ◽  
Lateral Sclerosis

Bunina bodies in amyotrophic lateral sclerosis immunostained with rabbit anti-cystatin C serum

1993 ◽  
Vol 162 (1-2) ◽  
pp. 125-128 ◽  
Author(s):  
Koichi Okamoto ◽  
Shunsaku Hirai ◽  
Masakuni Amari ◽  
Mitsunori Watanabe ◽  
Atsushi Sakurai
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Cystatin C ◽  
Bunina Bodies ◽  
Lateral Sclerosis

Peripherin partially localizes in Bunina bodies in amyotrophic lateral sclerosis

2011 ◽  
Vol 302 (1-2) ◽  
pp. 14-18 ◽  
Author(s):  
Yuji Mizuno ◽  
Yukio Fujita ◽  
Masamitsu Takatama ◽  
Koichi Okamoto
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Bunina Bodies ◽  
Lateral Sclerosis

INTRACYTOPLASMIC INCLUSIONS (BUNINA BODIES) IN AMYOTROPHIC LATERAL SCLEROSIS

1980 ◽  
Vol 30 (4) ◽  
pp. 591-597 ◽  
Author(s):  
Koichi Okamoto ◽  
Mitsunori Morimatsu ◽  
Shunsaku Hiraj ◽  
Yoichi Ishida
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Bunina Bodies ◽  
Intracytoplasmic Inclusions ◽  
Lateral Sclerosis
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