Sarcomatoid carcinoma of the small intestine: Histologic, immunohistochemical and ultrastructural features of three cases and its differential diagnosis

Sarcomatoid carcinoma (SC) is a well defined tumor type that may occur in all organs and anatomic sites but most commonly in the head1, neck1, respiratory tract2-4, breast5, and genitourinary tract6-11. It is a biphasic tumor showing both epithelial- and mesenchymal-like differentiation; however, its carcinomatous nature is widely recognized12. SC is rare in the gastrointestinal tract. In the esophagus it accounts for less than 5% of all malignancies12-16 and approximately only 35 cases have been described in the stomach12,17-18. Very few cases have been observed in the small intestine19-20, anorectal junction21, liver22, and pancreas23-24. To our knowledge only eight cases of SC have been reported in the colon25-32. We report a case of primary colonic SC. Both morphological and immunohistochemical analyses are provided along with an evaluation of the unusual clinical history, therapeutic implications, and controversial differential diagnosis.

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Metastatic Melanoma Presenting as Intussusception in an 80-Year-Old Man: A Case Report

Case Reports in Pathology ◽

10.1155/2013/672816 ◽

2013 ◽

Vol 2013 ◽

pp. 1-3 ◽

Cited By ~ 1

Author(s):

Sarah Alghamdi ◽

Yumna Omarzai

Keyword(s):

Differential Diagnosis ◽

Small Intestine ◽

Gastrointestinal Tract ◽

Metastatic Melanoma ◽

Clinical Presentation ◽

Gastrointestinal Symptoms ◽

Common Site ◽

Neoplastic Process ◽

History Of ◽

Uncommon Neoplasm

Malignant melanoma of the gastrointestinal tract is an uncommon neoplasm that could be primary or metastatic. Small intestine represents the most common site for the metastatic melanoma; however, it could be found anywhere in the gastrointestinal tract. Intussusception is a rare cause of intestinal obstruction in adults compared to children. In 90% of the cases, the underlying cause can be found, and in 65% of the cases, intussusception is caused by the neoplastic process. The majority of the neoplasms are benign, and about 15% are malignant. Metastatic melanoma is one of the most common metastatic malignancies to the gastrointestinal tract; however, the premortem diagnosis is rarely made. Here, we report an uncommon clinical presentation of metastatic melanoma causing intussusception in an 80-year-old man. This diagnosis should be considered in a differential diagnosis in any patient who presents with gastrointestinal symptoms and a history of melanoma.

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Aggressive Monophasic Sarcomatoid Carcinoma of Small Intestine - A Rare Case Report With Review of Literature

Journal of Health and Allied Sciences NU ◽

10.1055/s-0040-1703557 ◽

2012 ◽

Vol 02 (01) ◽

pp. 45-47

Author(s):

Shetty K. Padma ◽

Harish S. Permi ◽

C.N. Patil ◽

Michelle Mathias

Keyword(s):

Small Intestine ◽

Rare Case ◽

Spindle Cell ◽

Correct Diagnosis ◽

Sarcomatoid Carcinoma ◽

Intestinal Wall ◽

Cell Tumor ◽

Review Of Literature ◽

Spindle Cells ◽

Rare Case Report

AbstractSarcomatoid carcinoma occurring in the small intestine is very rare. They can be monophasic or biphasic. We report a rare case of monophasic Sarcomatoid carcinoma of the small intestine in a 60 year old male patient. The tumor was an ulceronodular mass involving the ileum circumferentially. The tumor infiltrated the full thickness of the intestinal wall and the serosa of an adjacent loop of ileum. Microscopically, the tumor was composed of sheets of malignant spindle cells. The carcinomatous nature of the tumor was evident only after Immunohistochemistry. The diagnosis of sarcomatoid carcinoma should be considered in the differential diagnosis of malignant spindle cell tumor of small intestine and immunohistochemical stains are required for the correct diagnosis.

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Sarcomatoid Carcinoma of Small Intestine: A Case

Chonnam Medical Journal ◽

10.4068/cmj.2021.57.1.89 ◽

2021 ◽

Vol 57 (1) ◽

pp. 89

Author(s):

Nurwahyuna Rosli ◽

Nordashima Abd Shukor

Keyword(s):

Small Intestine ◽

Sarcomatoid Carcinoma

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Functional disorders of the gastrointestinal tract in young children

Kazan medical journal ◽

10.17816/kazmj70908 ◽

1986 ◽

Vol 67 (6) ◽

pp. 441-444

Author(s):

R. F. Akberov

Keyword(s):

Differential Diagnosis ◽

Small Intestine ◽

Gastrointestinal Tract ◽

Young Children ◽

Clinical Medicine ◽

Functional Disorders

Functional disorders of the gastrointestinal tract in young children are the most difficult and insufficiently studied issues of clinical medicine. So far, such relevant issues as the mechanism of regurgitation and vomiting, the origin of pylorostenosis and dyskinetic disorders of the small intestine have not been elucidated. Unified methods of diagnosis and differential diagnosis of both functional and organic changes of the gastrointestinal tract, especially in children in the first days of life, have not been developed.

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Anaplastic and sarcomatoid carcinoma of the small intestine: A clinicopathologic study

Human Pathology ◽

10.1016/0046-8177(89)90097-x ◽

1989 ◽

Vol 20 (9) ◽

pp. 858-863 ◽

Cited By ~ 30

Author(s):

Susan S. Robey-Cafferty ◽

Elvio G. Silva ◽

Karen R. Cleary

Keyword(s):

Small Intestine ◽

Sarcomatoid Carcinoma ◽

Clinicopathologic Study

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SARCOMATOID CARCINOMA OF THE SMALL INTESTINE

ANZ Journal of Surgery ◽

10.1111/j.1445-2197.1996.tb00836.x ◽

1996 ◽

Vol 66 (9) ◽

pp. 636-639 ◽

Cited By ~ 7

Author(s):

K. Y. Lam ◽

C. Y. Leung ◽

J. W. C. Ho

Keyword(s):

Small Intestine ◽

Sarcomatoid Carcinoma

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A CASE REPORT OF SARCOMATOID CARCINOMA OF THE BLADDER WITH METASTASIS TO SMALL INTESTINE

The Japanese Journal of Urology ◽

10.5980/jpnjurol1989.96.640 ◽

2005 ◽

Vol 96 (6) ◽

pp. 640-643

Author(s):

Takako Masue ◽

Mitsuhiro Taniguchi ◽

Toshimi Takeuchi ◽

Shunsuke Sakai

Keyword(s):

Small Intestine ◽

Case Report ◽

Sarcomatoid Carcinoma ◽

Carcinoma Of The Bladder

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Acute inflammatory bowel disease of the small intestine in adult: MDCT findings and criteria for differential diagnosis

Clinical Imaging ◽

10.1016/j.clinimag.2009.06.008 ◽

2009 ◽

Vol 33 (5) ◽

pp. 413

Author(s):

S. Romano ◽

A. Russo ◽

S. Daniele ◽

G. Tortora ◽

F. Maisto ◽

...

Keyword(s):

Inflammatory Bowel Disease ◽

Differential Diagnosis ◽

Small Intestine ◽

Bowel Disease ◽

Inflammatory Bowel

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Inflammatory Myofibroblastic Tumor of the Bladder

Archives of Pathology & Laboratory Medicine ◽

10.5858/arpa.2014-0274-cc ◽

2014 ◽

Vol 138 (10) ◽

pp. 1272-1277 ◽

Cited By ~ 13

Author(s):

Megan Alderman ◽

Lakshmi P. Kunju

Keyword(s):

Differential Diagnosis ◽

Urinary Bladder ◽

Inflammatory Myofibroblastic Tumor ◽

Sarcomatoid Carcinoma ◽

Muscularis Propria ◽

Inflammatory Cells ◽

Diagnostic Features ◽

Anaplastic Lymphoma ◽

Diagnostic Pitfall ◽

Eosinophilic Cytoplasm

We illustrate a case of an inflammatory myofibroblastic tumor (IMT) involving the bladder in a woman with dysuria and review the literature and differential diagnosis. Inflammatory myofibroblastic tumor, also referred to as pseudosarcomatous myofibroblastic proliferation, is a rare lesion that can arise in the genitourinary system and is characterized by a fascicular arrangement of myofibroblasts with admixed inflammatory cells and slitlike vessels. Urinary bladder IMT can be a diagnostic pitfall because its histologic features (brisk mitoses, invasion into muscularis propria, and prominent nucleoli) can mimic malignancy. The differential diagnosis of urinary bladder IMT includes sarcomatoid carcinoma and leiomyosarcoma. Diagnostic features such as bland nuclear chromatin, ganglion-like cells, pale eosinophilic cytoplasm with long processes, overexpression of anaplastic lymphoma kinase (immunohistochemistry or gene rearrangement studies), and the absence of atypical mitoses help distinguish IMT from its malignant mimics. Current controversies regarding postoperative spindle cell nodule and IMT are discussed.

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