Sarcomatoid carcinoma (SC) is a well defined tumor type that may occur in all organs and anatomic sites but most commonly in the head1, neck1, respiratory tract2-4, breast5, and genitourinary tract6-11. It is a biphasic tumor showing both epithelial- and mesenchymal-like differentiation; however, its carcinomatous nature is widely recognized12. SC is rare in the gastrointestinal tract. In the esophagus it accounts for less than 5% of all malignancies12-16 and approximately only 35 cases have been described in the stomach12,17-18. Very few cases have been observed in the small intestine19-20, anorectal junction21, liver22, and pancreas23-24. To our knowledge only eight cases of SC have been reported in the colon25-32. We report a case of primary colonic SC. Both morphological and immunohistochemical analyses are provided along with an evaluation of the unusual clinical history, therapeutic implications, and controversial differential diagnosis.
Sarcomatoid Carcinoma of Small Intestine: A Case
