Endoscopic TriModal imaging and biomarkers for neoplasia conjoined: a feasibility study in Barrett's esophagus

2012 ◽  
Vol 27 (5) ◽  
pp. 435-443 ◽  
Author(s):  
D. F. Boerwinkel ◽  
M. Di Pietro ◽  
X. Liu ◽  
M. K. Shariff ◽  
P. Lao-Sirieix ◽  
...  
Keyword(s):  
Barrett’S Esophagus ◽  
Feasibility Study ◽  
Barrett's Esophagus

Mo1192 ENDOROTOR ABLATION OF BARRETT'S ESOPHAGUS; A SAFETY AND FEASIBILITY STUDY

2019 ◽  
Vol 89 (6) ◽  
pp. AB457
Author(s):  
Annieke W. Gotink ◽  
Yonne Peters ◽  
Marco J. Bruno ◽  
Peter D. Siersema ◽  
Arjun D. Koch
Keyword(s):  
Barrett’S Esophagus ◽  
Feasibility Study ◽  
Barrett's Esophagus

Selected commentary to “Treatment of Barrett’s esophagus with a novel focal cryoablation device: a safety and feasibility study”

2015 ◽  
Vol 47 (5) ◽  
pp. 274-278
Author(s):  
I. Kristo ◽  
F. M. Riegler ◽  
R. Asari ◽  
E. Cosentini ◽  
S. F. Schoppmann
Keyword(s):  
Barrett’S Esophagus ◽  
Feasibility Study ◽  
Barrett's Esophagus

scholarly journals A feasibility study of photoacoustic imaging of ex vivo endoscopic mucosal resection tissues from Barrett’s esophagus patients

2017 ◽  
Vol 05 (08) ◽  
pp. E775-E783 ◽  
Author(s):  
Liang Lim ◽  
Catherine Streutker ◽  
Norman Marcon ◽  
Maria Cirocco ◽  
Alexandra Lao ◽  
...  
Keyword(s):  
Barrett’S Esophagus ◽  
Endoscopic Mucosal Resection ◽  
Feasibility Study ◽  
Barrett's Esophagus ◽  
Ex Vivo ◽  
Photoacoustic Imaging ◽  
Esophageal Mucosa ◽  
Mucosal Resection ◽  
Total Hemoglobin

Abstract Background and study aims Accurate endoscopic detection of dysplasia in patients with Barrett’s esophagus (BE) remains a major clinical challenge. The current standard is to take multiple biopsies under endoscopic image guidance, but this leaves the majority of the tissue unsampled, leading to significant risk of missing dysplasia. Furthermore, determining whether there is submucosal invasion is essential for proper staging. Hence, there is a clinical need for a rapid in vivo wide-field imaging method to identify dysplasia in BE, with the capability of imaging beyond the mucosal layer. We conducted an ex vivo feasibility study using photoacoustic imaging (PAI) in patients undergoing endoscopic mucosal resection (EMR) for known dysplasia. The objective was to characterize the esophageal microvascular pattern, with the long-term goal of performing in vivo endoscopic PAI for dysplasia detection and therapeutic guidance. Materials and methods EMR tissues were mounted luminal side up. The tissues were scanned over a field of view of 14 mm (width) by 15 mm (depth) at 680, 750, and 850 nm (40 MHz acoustic central frequency). Ultrasound and photoacoustic images were simultaneously acquired. Tissues were then sliced and fixed in formalin for histopathology with hematoxylin and eosin staining. A total of 13 EMR specimens from eight patients were included in the analysis, which consisted of co-registration of the photoacoustic images with corresponding pathologist-classified histological images. We conducted mean difference test of the total hemoglobin distribution between tissue classes. Results Dysplastic and nondysplastic BE can be distinguished from squamous tissue in 84 % of region-of-interest comparisons (42/50). However, the ability of intrinsic PAI to distinguish dysplasia from NDBE, which is the clinically important challenge, was only about 33 % (10/30). Conclusion We demonstrated the technical feasibility of this approach. Based on our ex vivo data, changes in total hemoglobin content from intrinsic PAI (i. e. without exogenous contrast) can differentiate BE from squamous esophageal mucosa. However, most likely intrinsic PAI is unable to differentiate dysplastic from nondysplastic BE with adequate sensitivity for clinical translation.

scholarly journals Minichromosomal Maintenance Component Complex 5 (MCM5) as a Marker of Barrett’s Esophagus-Related Neoplasia: A Feasibility Study

2019 ◽  
Vol 64 (10) ◽  
pp. 2815-2822
Author(s):  
M. Everson ◽  
C. Magee ◽  
D. Alzoubaidi ◽  
S. Brogden ◽  
D. Graham ◽  
...  
Keyword(s):  
Barrett’S Esophagus ◽  
Feasibility Study ◽  
Barrett's Esophagus

scholarly journals Treatment of Barrett’s esophagus with a novel focal cryoablation device: a safety and feasibility study

Endoscopy ◽  
2015 ◽  
Vol 47 (12) ◽  
pp. 1106-1112 ◽  
Author(s):  
Dirk Schölvinck ◽  
Hannah Künzli ◽  
Christine Kestens ◽  
Peter Siersema ◽  
Frank Vleggaar ◽  
...  
Keyword(s):  
Barrett’S Esophagus ◽  
Feasibility Study ◽  
Barrett's Esophagus

Radiofrequency ablation and endoscopic resection in a single session for Barrett’s esophagus containing early neoplasia: a feasibility study

Endoscopy ◽  
2012 ◽  
Vol 44 (12) ◽  
pp. 1096-1104 ◽  
Author(s):  
F. van Vilsteren ◽  
L. Alvarez Herrero ◽  
R. Pouw ◽  
M. Visser ◽  
F. ten Kate ◽  
...  
Keyword(s):  
Radiofrequency Ablation ◽  
Barrett’S Esophagus ◽  
Feasibility Study ◽  
Endoscopic Resection ◽  
Barrett's Esophagus ◽  
Single Session

Sa1583 First Human Feasibility Study on Third Generation Autofluorescence Endoscopy for the Detection of Early Neoplasia in Barrett's Esophagus

2012 ◽  
Vol 75 (4) ◽  
pp. AB210 ◽  
Author(s):  
David F. Boerwinkel ◽  
Jasmin Holz ◽  
Maurice Aalders ◽  
Bas L. Weusten ◽  
Mike Visser ◽  
...  
Keyword(s):  
Barrett’S Esophagus ◽  
Feasibility Study ◽  
Barrett's Esophagus ◽  
Third Generation ◽  
Autofluorescence Endoscopy
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