scholarly journals β-Secretase-1 elevation in aged monkey and Alzheimer’s disease human cerebral cortex occurs around the vasculature in partnership with multisystem axon terminal pathogenesis and β-amyloid accumulation

2010 ◽  
Vol 32 (7) ◽  
pp. 1223-1238 ◽  
Author(s):  
Yan Cai ◽  
Kun Xiong ◽  
Xue-Mei Zhang ◽  
Huaibin Cai ◽  
Xue-Gang Luo ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebral Cortex ◽  
Axon Terminal ◽  
Human Cerebral Cortex ◽  
Amyloid Accumulation ◽  
Aged Monkey ◽  
Β Amyloid

scholarly journals Treatment with a Copper-Zinc Chelator Markedly and Rapidly Inhibits β-Amyloid Accumulation in Alzheimer's Disease Transgenic Mice

Neuron ◽  
2001 ◽  
Vol 30 (3) ◽  
pp. 665-676 ◽  
Author(s):  
Robert A Cherny ◽  
Craig S Atwood ◽  
Michel E Xilinas ◽  
Danielle N Gray ◽  
Walton D Jones ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Transgenic Mice ◽  
Amyloid Accumulation ◽  
Zinc Chelator ◽  
Copper Zinc ◽  
Β Amyloid

scholarly journals High levels of synaptosomal Na+–Ca2+ exchangers (NCX1, NCX2, NCX3) co-localized with amyloid-beta in human cerebral cortex affected by Alzheimer's disease

Cell Calcium ◽  
2011 ◽  
Vol 49 (4) ◽  
pp. 208-216 ◽  
Author(s):  
Sophie Sokolow ◽  
Sanh H. Luu ◽  
Alison J. Headley ◽  
Alecia Y. Hanson ◽  
Taeree Kim ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebral Cortex ◽  
Amyloid Beta ◽  
Human Cerebral Cortex

scholarly journals Microglia in Alzheimer’s Disease: A Target for Therapeutic Intervention

2021 ◽  
Vol 15 ◽  
Author(s):  
Guimei Zhang ◽  
Zicheng Wang ◽  
Huiling Hu ◽  
Meng Zhao ◽  
Li Sun
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Therapeutic Interventions ◽  
Tau Pathology ◽  
Age Related ◽  
Amyloid Accumulation ◽  
Pathophysiological Role ◽  
Inflammatory Drugs ◽  
Β Amyloid

Alzheimer’s disease (AD) is one of the most common types of age-related dementia worldwide. In addition to extracellular amyloid plaques and intracellular neurofibrillary tangles, dysregulated microglia also play deleterious roles in the AD pathogenesis. Numerous studies have demonstrated that unbridled microglial activity induces a chronic neuroinflammatory environment, promotes β-amyloid accumulation and tau pathology, and impairs microglia-associated mitophagy. Thus, targeting microglia may pave the way for new therapeutic interventions. This review provides a thorough overview of the pathophysiological role of the microglia in AD and illustrates the potential avenues for microglia-targeted therapies, including microglial modification, immunoreceptors, and anti-inflammatory drugs.

scholarly journals Limiting RyR2 Open Time Prevents Alzheimer’s Disease-Related Neuronal Hyperactivity and Memory Loss but Not β-Amyloid Accumulation

Cell Reports ◽  
2020 ◽  
Vol 32 (12) ◽  
pp. 108169 ◽  
Author(s):  
Jinjing Yao ◽  
Bo Sun ◽  
Adam Institoris ◽  
Xiaoqin Zhan ◽  
Wenting Guo ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Memory Loss ◽  
Open Time ◽  
Amyloid Accumulation ◽  
Β Amyloid
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