A new test for linkage in affected sib pairs

GeneScreen ◽  
2008 ◽  
Vol 1 (2) ◽  
pp. 53-54
Author(s):  
Sanjay S. Shete ◽  
Christopher I. Amos
Keyword(s):  
Affected Sib Pairs ◽  
Sib Pairs

A Robust Identity-by-Descent Procedure Using Affected Sib Pairs: Multipoint Mapping for Complex Diseases

2000 ◽  
Vol 51 (1-2) ◽  
pp. 64-78 ◽  
Author(s):  
Kung-Yee Liang ◽  
Yen-Feng Chiu ◽  
Terri H. Beaty
Keyword(s):  
Complex Diseases ◽  
Identity By Descent ◽  
Affected Sib Pairs ◽  
Sib Pairs ◽  
Multipoint Mapping

Family studies in multiple sclerosis: HLA haplotypes of affected sib-pairs

1984 ◽  
Vol 234 (1) ◽  
pp. 5-7 ◽  
Author(s):  
H. J. Mayer-Rienecker ◽  
S. Wegener ◽  
B. Hitzschke
Keyword(s):  
Multiple Sclerosis ◽  
Family Studies ◽  
Hla Haplotypes ◽  
Affected Sib Pairs ◽  
Sib Pairs

scholarly journals Gene‐based and pathway‐based testing for rare‐variant association in affected sib pairs

2020 ◽  
Vol 44 (4) ◽  
pp. 368-381
Author(s):  
Razvan G. Romanescu ◽  
Jessica Green ◽  
Irene L. Andrulis ◽  
Shelley B. Bull
Keyword(s):  
Rare Variant ◽  
Rare Variant Association ◽  
Affected Sib Pairs ◽  
Sib Pairs

scholarly journals Incorporating quantitative variables into linkage analysis using affected sib pairs

2007 ◽  
Vol 1 (S1) ◽  
Author(s):  
Yen-Feng Chiu ◽  
Jeng-Min Chiou ◽  
Yi-Shin Chen ◽  
Hui-Yi Kao ◽  
Fang-Chi Hsu
Keyword(s):  
Linkage Analysis ◽  
Affected Sib Pairs ◽  
Sib Pairs

scholarly journals MP7: FAMILIES WITH BOTH NON-HODGKIN'S LYMPHOMA (NHL) AND MYELOMA (MM): ANTICIPATION AND MALE TRANSMISSION

2016 ◽  
Vol 64 (3) ◽  
pp. 807.1-807
Author(s):  
PH Wiernik ◽  
JP Dutcher
Keyword(s):  
Hodgkin’S Lymphoma ◽  
Hematologic Malignancies ◽  
Hodgkin's Lymphoma ◽  
Same Sex ◽  
Autosomal Region ◽  
Non Hodgkin’S Lymphoma ◽  
Non Hodgkin's Lymphoma ◽  
Affected Sib Pairs ◽  
The Relationship ◽  
Sib Pairs

Purpose of StudyTo determine whether genetic rather than environmental factors may be responsible for the occurrence of these neoplasms in families.Methods UsedWe interrogated our registry of >700 pedigrees of families (fams) with multiple hematologic malignancies. We identified 31 fams with both NHL and MM in their pedigrees. In 16 pedigrees a parent and child were affected (12 father-child pairs and 4 mother-child pairs). Fifteen affected sib pairs were identified in the 31 fams, 10 same sex pairs and 5 male-female pairs. Six of the 31 pedigrees had only 1 affected pair. More distant relationships were observed in other fams.Summary of ResultsMale transmission was evident in 25 fams and female transmission was observed in 6. NHL and MM cases had at least 1 unaffected generation (gen) between them in 8 pedigrees, and the diseases occurrred in sequential (13 fams) or the same gen in 10 fams. MM was the diagnosis (dx) in the youngest affected gen in 9 pedigrees, NHL in 13 pedigrees and both occurred in the youngest gen in 9 fams. The median age at dx of 29 NHL patients for whom data were available was 55 yrs (range, 20–99 yrs), and the median age at dx of 26 MM cases was 56 yrs (range, 30–82 yrs). Ten of 26 MM patients were <50 years old at dx. The presence or absence of anticipation could be assessed in 15 of the 31 pedigrees. All 15 displayed anticipation in terms of succeeding gens developing NHL or MM at an earlier age than did the previous gens (median −19 yrs, range −6 to −56 yrs).ConclusionsWe demonstrate anticipation in 15 assessible fams with both NHL and MM, a feature of familial MM that we previoiusly reported (Despande HA, et al: Br J Haematol 1998). More advanced, aggressive disease at dx in the youngest gen is another feature of anticipation, and was observed in 9 of 13 fams in which it could be assessed. Demonstration of anticipation in all 15 evaluable fams suggests a genetic basis for the relationship between these two B-cell disorders. The increase of same sex sib pairs among affected sib pairs implicates a locus on a pseudo-autosomal region of the X chromonsome as potentially responsible for this observation, as we have previously reported for Hodgkin's lymphoma (Horwitz M, Wiernik PH, Am J Hum Genet 1999). Myeloma and non-Hodgkin's lymphoma may have common genetic causation; molecular studies of these fams are planned.

A multimarker regression-based test of linkage for affected sib-pairs at two linked loci

2006 ◽  
Vol 30 (3) ◽  
pp. 191-208 ◽  
Author(s):  
Mathew J. Barber ◽  
John A. Todd ◽  
Heather J. Cordell
Keyword(s):  
Affected Sib Pairs ◽  
Sib Pairs

OB gene not linked to human obesity in Mexican American affected sib pairs from Starr County, Texas

1996 ◽  
Vol 98 (5) ◽  
pp. 590-595 ◽  
Author(s):  
Molly S. Bray ◽  
Eric Boerwinkle ◽  
C. L. Hanis
Keyword(s):  
Mexican American ◽  
Human Obesity ◽  
Ob Gene ◽  
Affected Sib Pairs ◽  
Sib Pairs ◽  
Starr County
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