Original semiologic standardized evaluation of stratum corneum hydration by DiagnoskinR stripping sample

Abstract Objectives Batik dyes contain irritant chemicals that increase the risk of skin barrier disruption. This study aims to determine the effect of Centella asiatica and ceramide in transepidermal water loss (TEWL), hydration of the stratum corneum and skin acidity (pH). Methods This was a double blind clinical trial of 30 Indonesian batik workers who suffered from skin dryness, but had no clinical manifestation of contact dermatitis. Subjects were given cream containing C. asiatica or ceramide that formulated and randomly labeled by manufacturer (PT Paragon Technology and Innovation). Both subjects and researchers were blinded to the type of the cream. Cream was applied to the hands and arms twice a day. Biological function of the skin (TEWL, stratum corneum hydration level, and skin acidity) was examined by Cutometer dual MP-580. Baseline was recorded in the first examination, followed by second and third examinations at two and four weeks after treatment. Results After four weeks treatment, there were significant improvement of C. asiatica application in evaluation of corneometer palmar (p=0.007; CI 95%), corneometer dorsum (p=0.001; CI 95%), and skin acidity dorsum (p=0.017; CI 95%). Ceramide application also gave significant improvement of corneometer palmar (0.038; CI 95%), skin acidity palmar (p=0.001; CI 95%), TEWL dorsum (p=0.023; CI 95%), corneometer dorsum (p=0.002; CI 95%) and skin acidity dorsum (p=0.011; CI 95%). There were no significant differences of C. asiatica effectiveness compared to ceramide in skin barrier improvement. Conclusions C. asiatica and ceramide can improve skin barrier hydration in order to prevent the risk of contact dermatitis in batik workers.

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Beneficial effects of oral supplementation with ferulic acid, a plant phenolic compound, on the human skin barrier in healthy men

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000699 ◽

2021 ◽

pp. 1-7

Author(s):

Atsushi Suzuki ◽

Tomoko Nomura ◽

Hiroko Jokura ◽

Naoya Kitamura ◽

Akihiko Fujii ◽

...

Keyword(s):

Ferulic Acid ◽

Stratum Corneum ◽

Water Loss ◽

Nervous Activity ◽

Skin Barrier ◽

Transepidermal Water Loss ◽

Sympathetic Nervous Activity ◽

Healthy Men ◽

Stratum Corneum Hydration ◽

Sympathetic Nervous

Abstract. Ferulic acid (FA) is a phytochemical compound with various physiologic functions. To clarify the effect of FA intake on skin barrier function (SBF), we conducted a placebo-controlled double-blind pilot trial. Sixteen healthy subjects were divided into 2 groups (n = 8) and ingested capsules containing either FA (200 mg) or placebo daily for 2 weeks. Two measures of SBF, transepidermal water loss and stratum corneum hydration, were assessed before and 2 weeks after the start of the study. Autonomic nervous activity, which is suggested to be related to SBF, was also measured. Compared with the values obtained before the start of the study, FA intake significantly reduced transepidermal water loss (from 6.1 ± 1.1 to 4.8 ± 1.0 g/m2/h, p = 0.005) and increased stratum corneum hydration (from 30.1 ± 7.6 to 32.3 ± 8.1 a.u., p = 0.027) after 2 weeks. In addition, the amount change in sympathetic nervous activity was significantly reduced after ingesting the FA capsules compared with the placebo capsules (−0.7 ± 1.6 vs. 1.1 ± 1.4, p = 0.035). These findings suggest that FA supplementation decreases sympathetic nervous activity and strengthens SBF in healthy men.

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Epidermal thermal conductivity and stratum corneum hydration in cat footpad

American Journal of Physiology-Legacy Content ◽

10.1152/ajplegacy.1975.228.6.1903 ◽

1975 ◽

Vol 228 (6) ◽

pp. 1903-1908 ◽

Cited By ~ 8

Author(s):

KR Holmes ◽

T Adams

Keyword(s):

Thermal Conductivity ◽

Stratum Corneum ◽

Water Content ◽

Skin Surface ◽

Blocking Agent ◽

Eccrine Sweat Gland ◽

Dermoepidermal Junction ◽

Stratum Corneum Hydration ◽

Cutaneous Vasoconstriction ◽

Stratum Corneum Water Content

Epidermal thermal conductivity (k) was calculated for the cat footpad by measuringtransepidermal heat flux and temperature gradient ( inverted question markT) while changes in stratum corneum water content were produced by "internal hydration" (IH; eccrine sweat gland activity by nerve stimulation) or by "external hydration" (HH; exposure to air saturated with water vapor). In some experiments, cutaneous vasoconstriction accompanying IH was prevented by an alpha-adrenergic receptor blocking agent, phenoxybenzamine (POB), 3.52 mg/kg iv. For dry skin k=0.167 plus or minus 0.023 (SE) W.m (-1) degree C (-1). With and without POB, IH produced 49.5% and 17.2% increases in k, respectively; HH after IH did not increase k more. With POB, IH increased k more than did HH alone (49.5% and 15.5%, respectively) and at a higher rate (4.22 times 10 minus 3 and 0.63 times 10 minus 3 W.m minus 1.degree C minus 1. min minus 1, respectively.) As k increased, usually deltaT decreased. Increasing k and decreasing deltaT with skin hydration explain the phenominon that air temperature is felt to be lower the more humid a cold exposure, since the temperature of thermoreceptors at the dermoepidermal junction is closer to that of the skin surface when the corneum is hydrated than when it has a low water content.

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Effect of an Oral Nutrition Supplement Containing Collagen Peptides on Stratum Corneum Hydration and Skin Elasticity in Hospitalized Older Adults

Advances in Skin & Wound Care ◽

10.1097/01.asw.0000655492.40898.55 ◽

2020 ◽

Vol 33 (4) ◽

pp. 186-191

Author(s):

Tatsuya Nomoto ◽

Shinji Iizaka

Keyword(s):

Older Adults ◽

Stratum Corneum ◽

Skin Elasticity ◽

Oral Nutrition ◽

Collagen Peptides ◽

Stratum Corneum Hydration ◽

Nutrition Supplement ◽

Hospitalized Older Adults

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Is Endogenous Glycerol a Determinant of Stratum Corneum Hydration in Humans?

Journal of Investigative Dermatology ◽

10.1111/j.0022-202x.2005.23799.x ◽

2005 ◽

Vol 125 (2) ◽

pp. 288-293 ◽

Cited By ~ 66

Author(s):

Eung Ho Choi ◽

Mao-Qiang Man ◽

Fusheng Wang ◽

Xinjiang Zhang ◽

Barbara E. Brown ◽

...

Keyword(s):

Stratum Corneum ◽

Stratum Corneum Hydration

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Fine Wrinkle Treatment and Hydration on the Facial Dermis Using HydroToxin Mixture of MicroBotox and MicroHyaluronic Acid

Aesthetic Surgery Journal ◽

10.1093/asj/sjaa231 ◽

2020 ◽

Author(s):

Jong Seo Kim

Keyword(s):

Stratum Corneum ◽

Intradermal Injection ◽

The Novel ◽

Level Of Evidence ◽

Injection Method ◽

Stratum Corneum Hydration ◽

Crow’S Feet ◽

The Face ◽

Injection Depth ◽

Pre Treatment

Abstract Background Hyaluronic acid (HA) is a key contributor to skin moisture (hydration), and MicroBotox demonstrates improvements for fine wrinkles of the face. Objectives The author sought to evaluate the safety and efficacy of intradermal injection of hydrotoxin (combined mixture of MicroHA and MicroBotox) for the treatment of skin roughness and dryness on facial dermis. Methods Fifty women who had thin, dry skin with fine wrinkles throughout the whole face, especially in the crow’s feet and forehead areas, were enrolled in the study. Two cc stabilized-HA filler and 1 cc (40 U) of botulinumtoxinA were mixed in the novel combined hydrotoxin mixture. Intended to hydrate the dermis and treat fine wrinkles of the face, the mixture was injected into the real dermal layer of the face. The volume of HA per site was 0.002 cc and toxin was 0.04 U. Skin roughness and stratum corneum hydration were measured at 1, 2, 3, and 6 months. Results One month post-treatment, skin roughness was reduced to 50.19% in topographic computer analysis utilizing 10× dermascope photos. Stratum corneum hydration on crow’s feet improved to 81.34% at 1 month and 56.12% at 2 months from pre-treatment baseline (P < 0.0001). Global Aesthetic improvement scale of Skin hydration and fine wrinkle improved. Conclusions The combination injection method of MicroHA and MicroBotox is not associated with side effects and showed significant synergic effect in improvement of skin roughness and moisturizing. Neuramix-hydrotoxin injection method is an easy and reproducible procedure to make constant injection depth and amount. Level of Evidence: 4

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