Skin Improvement Effect of Tencel Sheet Mask Pack Using Self-luminous LED Light Source

Purpose: This study intends to prove whether the efficacy already proven in the existing light therapy LED mask device is similarly exerted in the self-luminous LED sheet mask that does not require power.Methods: The experimental subjects of this study were women with an average age of 47.9 years, and the effect of improving 24-hour moisturizing lasting, skin elasticity, eye expression wrinkles, and facial (cheek) lifting was studied by prohibiting the use of cosmetics containing active ingredients that could affect the results and making them use an LED sheet type mask pack.Results: As a result of the experiment, the 24-hour moisturizing lasting power was 90.573% immediately after use and 37.384% after 24 hours, so it increased significantly (p<0.05), and skin elasticity was also increased by 7.087% immediately after use. After one week, it was increased significantly (p<0.025) to 11.181%. Expression wrinkles around the eyes were significantly reduced (p<0.05) to 1.621% immediately after use and 4.579% after 1 week of use. In the facial (cheek) lifting experiment, the cheek angle (°) was reduced to 2.065% immediately postuse compared to pre-use. Also, it was significantly decreased (p<0.05) with a result of 3.762% after 1 week of use, thus proving that the light therapy LED sheet mask is also effective for skin improvement.Conclusion: Using this research material as basic data, it is expected that various skincare products will be developed as well as mask packs with a simple and easy structure of effective light therapy.

POTENSI DARI EKSTRAK DAN FRAKSI KULIT BUAH MUNDAR (Garcinia forbesii) SEBAGAI TABIR SURYA BERDASARKAN NILAI SUN PROTECTION FACTOR (SPF)

UV rays cause skin damage such as loss of skin elasticity, wrinkles, sagging, and skin cancer. South Kalimantan is a wetland area with more than 4,000 species of medicinal plants. Mundar (Garcinia forbesii) is one of the plants in South Kalimantan. Mundar pericarp is empirically used for cosmetics which is believed to protect the skin from ultraviolet rays. The purpose of the study was to determine the sunscreen potency of the extract and fraction from pericarp of mundar (Garcinia forbesii) based on the Sun Protection Factor (SPF) parameter. The research started from material drying, making simplicia powder, extraction, and fractions. The extracts and fractions were measured for SPF values ??using a UV-Vis Spectrophotometer. The results showed that the ethanol extract and ethyl acetate fraction had weak protection, while the n-hexane fraction had extreme protective power with SPF values ??in the range of 6.51 – 30.00

Development, Characterization, and Clinical Investigation of a New Topical Emulsion System Containing a Castanea sativa Spiny Burs Active Extract

The study focused on the development and characterization of an O/W emulsion for skincare containing Castanea sativa spiny burs extract (CSE) as functional agent. The emulsion was stable and had suitable physicochemical and technological properties for dermal application and CSE showed no cytotoxicity in spontaneously immortalized keratinocytes (HaCaT) at active concentrations. A single-blind, placebo-controlled, monocentric study was designed to evaluate the skin tolerability and the skin performance of the CSE-loaded emulsion on healthy human volunteers. An improvement was observed in skin biomechanical properties such as hydration, skin elasticity and a reduction in the periorbital wrinkles in 30 days without altering the skin barrier function, sebum, pH, and erythema values. A significant skin moisturizing effect was detected while the skin barrier function was preserved. The selected natural ingredient combined with the designed formulation and the optimized preparation method has led to a final product that satisfies the physico-chemical and technological requirements underlying the safety of use and the formulative stability over time. With no negative skin reactions and highly significant effects on skin elasticity, wrinkles, and moisturization, the CSE-based emulsion achieved very satisfying outcomes representing a promising functional formulation for skin care.

Three New Dexpanthenol-Containing Face Creams: Performance and Acceptability after Single and Repeated Applications in Subjects of Different Ethnicity with Dry and Sensitive Skin

Three novel face creams containing dexpanthenol with different lipid contents were developed for dry skin sufferers: a day face cream (DFC), a day face cream with sun protection (DFC-SPF), and a night face cream (NFC). Three identically designed studies (N = 42–44 each) were conducted with healthy adults of three ethnicities (African, Asian, Caucasian) with dry/sensitive skin. Effects on stratum corneum (SC) hydration, SC lipid content, and skin elasticity were quantified by established noninvasive methods during the 4-week studies. After single and repeated once-daily applications of the face creams, facial hydration significantly increased from baseline. On day 28, the mean increments in skin hydration amounted to 27%, 26%, and 27% (p < 0.0001 each) for DFC, DFC-SPF, and NFC, respectively. Favorable effects of DFC, DFC-SPF, and NFC on facial moisturization were observed in all three ethnic groups. The enhancements in SC hydration were not paralleled by improvements in skin elasticity parameters but lipid analyses showed significant increases in SC cholesterol, SC free fatty acid, and/or SC ceramide levels. All three face creams were well tolerated and achieved a high product satisfaction and acceptability by study participants. Our findings support the once-daily use of the face creams in adults of different ethnicities with dry and sensitive skin.

Anti-Aging Effectiveness of Avocado Peel Extract Ointment (Persea americana Mill.) against Hydration, Collagen, and Elasticity Levels in Wistar Rat

The skin is a complex organ that protects the body from the external environment. The skin has a variety of functions such as providing a physical permeability barrier, protection from infectious agents, thermoregulation, sensation, protection against ultraviolet (UV) rays, regeneration, and wound healing. Clinically, aging skin is characterized by loss of hydration, rough texture, irregular pigmentation, yellowish discoloration, telangiectasia, deep wrinkles or wrinkles, thinning of the skin, and fine lines. One of the plants that can be used as natural ingredients that are rich in antioxidants and interesting to study is avocado (Persea americana Mill.) from the Lauraceae family, which is a plant that has medicinal properties and contains a variety of nutrients. Besides being consumed as food, avocados are also used as a mixture of cosmetic products. This study aims to assess the anti-aging effectiveness of avocado peel extract on increasing collagen levels, elasticity, and hydration in male rats. A total of 25 rats were divided into 5 groups, each group consisting of 5 white rats; control group (ointment base), avocado peel extract ointment group 2.5%, 5%, 7.5%, and 10%. The entire group of rats will be measured the condition before treatment with the Skin Analyzer EH 900 U including levels of collagen, elasticity, and hydration. After measuring the initial skin condition, the treatment was started by applying ointment until it was evenly distributed over the marked area, the ointment was applied according to the groups that have been set above, the application was carried out 2 times a day for 4 weeks. Changes in skin condition were measured weekly for 4 weeks using the EH 900 U skin analyzer. The results of this study indicate that the methanol extract of avocado peel contains phytochemicals in the form of alkaloids, tannins, phenols, flavonoids, and glycosides. Then the phenolic, flavonoid, and tannin content of the avocado peel methanol extract was 59.55 GAE mg/gram extract, 2.96 QE mg/gram extract, and 22.63 TAE mg/gram extract. After 4 weeks of treatment, there was a significant change in the level of hydration, collagen, and skin elasticity (p<0.05) in all treatment groups, this can be seen from the P-value <0.05, with the group of rats receiving the highest concentration of ointment (10%) showed the highest average, namely hydration 49.60%, collagen 40.20%, and elasticity 68.20%. Changes in hydration levels, collagen, and skin elasticity before and after treatment also showed significant changes (P-value < 0.05) with the highest changes found at a concentration of 10%, namely hydration 88.40%, collagen 60.0%, and elasticity 68.20%. In conclusion, the results of this study showed that administration of avocado peel extract ointment could increase hydration, collagen, and skin elasticity levels compared to controls groups, positively correlated with the increase of the duration and the quantity of avocado peel extract ointment were given. The best formulation that gives the most significant effect is 10% avocado peel extract ointment by increasing levels of hydration, collagen, and elasticity the most significantly.

Potential of Topical Microemulsion Serum Formulations to Enhance In Vitro and Clinical Anti-Skin Wrinkle Benefits of Cordyceps Militaris Extracts

This research is the first to investigate the anti-skin wrinkle properties of Cordyceps mili-taris extracts both in vitro and in vivo. Anti-skin wrinkle activities of C. militaris were investigated by means of matrix metalloproteinase-1 (MMP-1), elastase, and hyaluronidase inhibitions. Microemulsions and topical serum formulation containing C. militaris extract were developed. The anti-skin wrinkle efficacy and irritation properties of the topical serum formulations were clinically investigated in human volunteers. Cordycepin was identified as a major component of C. miliaris extract that was responsible for MMP-1, elastase, and hyaluronidase inhibition. The C. miliaris water extract possessed the most potent inhibition on MMP-1 (77.9 ± 5.3%) and elastase (84.4 ± 4.0%). Interestingly, CW was as a potent MMP-1 and elastase inhibitor as oleanolic acid and EGCG. CW was incorporated into the microemulsion with the smallest internal droplet size (146.1 ± 1.5 nm) and further developed as a topical serum formulation. The resulting serum formulation effectively enhanced skin moisture (42.2 ± 14.2%), increased the skin elasticity (39.9 ± 7.3%), and induced no skin irritation in 30 human volunteers. The effectiveness on the skin was detected after 1 week of the applications. Therefore, it was suggested as an effective anti-skin wrinkle formulation.

Effects of alpha-lipoic acid on the biomechanical properties of the skin

Background: The Cutometer MPA 580® (Courage and Khazaka, Germany) is a well-established instrument for the accurate and reproducible measurement of the biomechanical properties of the skin. The purpose of this study was to assess the effect of 4 formulations containing 2.5% and 5.0% of α-lipoic acid and ascorbic palmitate or butylhydroxytoluene on skin elasticity and firmness and to assess the equivalence between alternative parameters (Q0, Q1 and Q3) and the traditional parameters R0, R2, R5, R6, all determined with the same cutometer. Methods: Measure of in vivo firmness and elasticity of the skin was performed using R and Q parameters measured in the same device. Results: Different statistical analysis were applied to the results obtained from the parameters (Q0, Q1 and Q3) and the traditional parameters R0, R2, of the in vivo measurements after the application of the four formulations during 28 days. A correlation between both types of measurements was demonstrate. Conclusion: A four-week treatment with a cream containing 5% α-lipoic acid improves the biomechanical characteristics of the skin, thus contributing to the protection against photo-aging. Both methods of measurement proved to be equivalent.

Effects of Oral Supplementation of TrichovitalsTM on Human Skin, Hair and Nail Physiology

In this study, Microcore’s oral supplements of TrichovitalsTM contains Collagen type (I,III,V,X), elastin, ellagic acid, Sabbery b glucogallin, Biotin, Curcumin C3 reduct ODN and Murraya koenigii. ESM ingestion is associated with significant impact on hair thickness, reduction in hair breakage and improvement in hair growth. This study leads to evaluate the impacts of a nutritional intervention as compared to control group (without oral supplements intake) on the appearances of hair, skin, and nails in healthy middle-aged adults. Two pilot studies were run to assess TrichovitalsTM on skin parameter. 1. Self-assessment questionnaire intended to perform an assessment on skin, hair, and nail health after 12 weeks of treatment for a group of 25 female volunteers 2. Evaluated the efficacy of TrichovitalsTM effect of 5-week treatment on hydration of skin by corneometry, on elasticity with the cutometer, and on pigmentation with themexameteron for a group of 7 female volunteers, Microscopic studies of hair strength and nail growth. In study 1-Participants were predominantly satisfied with the effects obtained on general face (100% volunteers satisfied) and (94% volunteers satisfied) body skin condition and skin properties (100% volunteers satisfied) with facial skin softness, 95% ith facial skin hydration, 63% of facial skin brightness and 89% with body skin hydration and significant effects on hair damages (100% volunteers satisfied), hair falls (95% volunteers satisfied) and hair growth (96% volunteers satisfied) and nail appearance (80% volunteers satisfied) and improvement in brittle nails. In this open-label 5 weeks study, Oral Microcore’s TrichovitalsTM ingestion was associated with a significant improvement in skin appearance such as increase skin hydration and skin elasticity, reduces skin pigmentation after 5 weeks treatment and facial skin tone, with significant impact on hair thickness, reduces split ends, hair loss, hair breakage and improvement in hair growth after 5 weeks treatment, increase of 80% nail growth rate and a decrease of 42% brittle nails after 6 weeks. Microcore’s TrichovitalsTM achieved significant change improvement in skin, hair and nail appearance (thickness/density) than control group (without oral supplements intake) by week 12 of the study. From the result analysis, Microcore’s TrichovitalsTM is deemed to be one of the most effective anti-aging products in cosmetic sector and overall physical appearance. Oral supplementation of 500mg/day of Microcore’s TrichovitalsTM for 12 weeks is associated with significant improvement in the appearance of facial skin, hair and nail. Increases in skin hydration and skin elasticity with reduced pigmentation on skin were observed after 5 weeks treatment, which is a very important marker for skin aging. Also significant impact on hair thickness reduces split ends, hair loss, hair breakage and improvement in hair growth and healthy development of nails after 5 weeks treatment.