scholarly journals The role of GABAergic inputs for coincidence detection in the neurones of nucleus laminaris of the chick

1998 ◽  
Vol 508 (3) ◽  
pp. 851-869 ◽  
Author(s):  
Kazuo Funabiki ◽  
Konomi Koyano ◽  
Harunori Ohmori
2007 ◽  
Vol 24 (2) ◽  
pp. 222-234 ◽  
Author(s):  
Jorge F. Mejías ◽  
Joaquín J. Torres

Author(s):  
M.R. Scheinfein ◽  
J.S. Drucker ◽  
J.K. Weiss

The production or generation of SE by focused, fast electron beams is a multistage process which includes excitation of target electrons by the energetic incident beam, subsequent decay yielding hot SE, transport to the surface, and transmission over the surface potential barrier. The ultimate spatial resolution of a SE image formed by scanning a well focussed probe across a surface is limited by the excitation events' spatial derealization through the transverse momentum transferred to the specimen.The accepted model for SE production is not well characterized since it is extremely difficult to separate experimentally the generation, transport and transmission processes during a given SE creation event. Here, we examine the SE generation pathway by correlating SE of a given energy produced by an initial inelastic excitation using time coincidence detection. This technique can be used, for example, to isolate the role of plasmon decay in the SE generation process. The experiments were performed in a Vacuum Generators HB501-S UHV scanning transmission electron microscope (STEM), operating at base pressures of 5 × 10−11 torr.


2001 ◽  
Vol 38-40 ◽  
pp. 675-682 ◽  
Author(s):  
Satoru Inoue ◽  
Takafumi Yoshizawa ◽  
Yoshiki Kashimori ◽  
Takeshi Kambara

Nature ◽  
10.1038/30505 ◽  
1998 ◽  
Vol 393 (6682) ◽  
pp. 268-272 ◽  
Author(s):  
Hagai Agmon-Snir ◽  
Catherine E. Carr ◽  
John Rinzel

2001 ◽  
Vol 38-40 ◽  
pp. 285-291 ◽  
Author(s):  
Lovorka Pantic ◽  
Joaquı́n J. Torres ◽  
Hilbert J. Kappen

2000 ◽  
Vol 83 (6) ◽  
pp. 3310-3322 ◽  
Author(s):  
Jilda S. Nettleton ◽  
William J. Spain

It has been hypothesized that voltage-sensitive conductances present on the dendrites of neurons can influence summation of excitatory postsynaptic potentials (EPSPs) and hence affect how neurons compile information. Greater than linear summation of EPSPs has been postulated to facilitate coincidence detection by cortical neurons. This study examined whether the summation of subthreshold AMPA-mediated EPSPs generated on layer V neocortical pyramidal neurons in vitro was linear and if any nonlinearities could be attributed to dendritic conductances. Evoked EPSPs (1–12 mV) were recorded somatically by means of intracellular sharp electrodes in the presence of 100 μM amino-5-phosphonopentanoic acid (AP-5) and 3 μM bicuculline. Two independent EPSPs were evoked by a stimulating electrode in layer I and another in layers III–V. The areas of stimulation were isolated from each other by a horizontal cut below layer I. By subtracting the algebraic sum of the individual EPSPs from the evoked response when both EPSPs were evoked simultaneously, we determined that they summed linearly to supralinearly. Supralinear summation was more likely when the soma was hyperpolarized by DC current injection. Summation was predominantly linear when postsynaptic conductances (i.e., Na+ and Ca2+) were blocked with intracellular QX-314. The supralinear summation of EPSPs (without QX-314) decreased as the time between inputs was increased from 0 to 30 ms. To determine the role of dendrites in nonlinear summation, we substituted a current pulse (simulated EPSP) delivered at the soma for either or both of the evoked EPSPs. Simulated EPSPs combined with either an evoked EPSP or another simulated EPSP showed significantly less supralinear summation than two evoked EPSPs, indicating that the dendritic conductances were largely responsible for the observed supralinear summation.


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