scholarly journals Fast synaptic transmission mediated by P2X receptors in CA3 pyramidal cells of rat hippocampal slice cultures

2001 ◽  
Vol 535 (1) ◽  
pp. 115-123 ◽  
Author(s):  
Masahiro Mori ◽  
Christian Heuss ◽  
Beat H. Gähwiler ◽  
Urs Gerber
Keyword(s):  
Synaptic Transmission ◽  
Hippocampal Slice ◽  
Pyramidal Cells ◽  
P2x Receptors ◽  
Hippocampal Slice Cultures ◽  
Ca3 Pyramidal Cells

Effects of interferons and hydrogen peroxide on CA3 pyramidal cells in rat hippocampal slice cultures

1993 ◽  
Vol 619 (1-2) ◽  
pp. 157-162 ◽  
Author(s):  
Michael Mu¨ller ◽  
Adriano Fontana ◽  
Gerhard Zbinden ◽  
Beat H. Ga¨hwiler
Keyword(s):  
Hydrogen Peroxide ◽  
Hippocampal Slice ◽  
Pyramidal Cells ◽  
Hippocampal Slice Cultures ◽  
Ca3 Pyramidal Cells

Postsynaptic hyperpolarization increases the strength of AMPA-mediated synaptic transmission at large synapses between mossy fibers and CA3 pyramidal cells

2000 ◽  
Vol 39 (12) ◽  
pp. 2288-2301 ◽  
Author(s):  
Nicola Berretta ◽  
Aleksej V Rossokhin ◽  
Alexander M Kasyanov ◽  
Maxim V Sokolov ◽  
Enrico Cherubini ◽  
...  
Keyword(s):  
Synaptic Transmission ◽  
Mossy Fibers ◽  
Pyramidal Cells ◽  
Ca3 Pyramidal Cells

Erythropoietin improves synaptic transmission during and following ischemia in rat hippocampal slice cultures

2002 ◽  
Vol 958 (2) ◽  
pp. 305-311 ◽  
Author(s):  
Astrid Weber ◽  
Rolf F Maier ◽  
Ulrike Hoffmann ◽  
Martin Grips ◽  
Marc Hoppenz ◽  
...  
Keyword(s):  
Synaptic Transmission ◽  
Hippocampal Slice ◽  
Hippocampal Slice Cultures

Lack of AMPA Receptor Desensitization During Basal Synaptic Transmission in the Hippocampal Slice

1999 ◽  
Vol 81 (6) ◽  
pp. 3096-3099 ◽  
Author(s):  
Gregory O. Hjelmstad ◽  
John T. R. Isaac ◽  
Roger A. Nicoll ◽  
Robert C. Malenka
Keyword(s):  
Synaptic Transmission ◽  
Ampa Receptor ◽  
Ampa Receptors ◽  
Hippocampal Slice ◽  
Hippocampal Slices ◽  
Release Site ◽  
Pyramidal Cells ◽  
Receptor Desensitization ◽  
Synaptic Receptors ◽  
Basal Synaptic Transmission

Lack of AMPA receptor desensitization during basal synaptic transmission in the hippocampal slice. Excitatory postsynaptic currents in the CA1 region of rat hippocampal slices are mediated primarily by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in response to synaptically released glutamate. Outside-out patches from pyramidal cells in this region have shown that AMPA receptors are desensitized by short (1 ms) pulses of glutamate. We have taken a number of approaches to ask whether synaptic receptors desensitize in response to synaptically released glutamate in the slice. Recordings with paired pulses and minimal stimulation conditions that are presumably activating only a single release site do not show evidence for desensitization. Furthermore, cyclothiazide, a drug that blocks desensitization, does not alter paired-pulse ratios even under conditions of high probability of release, which should maximize desensitization. These results suggest that synaptic receptors do not desensitize in response to synaptically released glutamate during basal synaptic transmission.

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