GABA IN THE OLFACTORY BULB AND OLFACTORY NUCLEUS OF THE RAT: THE DISTRIBUTION OF GAMMA-AMINOBUTYRIC ACID, GLUTAMIC ACID DECARBOXYLASE, GABA TRANSAMINASE AND SUCCINATE SEMIALDEHYDE DEHYDROGENASE

1979 ◽  
Vol 32 (5) ◽  
pp. 1473-1477 ◽  
Author(s):  
L. Austin ◽  
M. Recasens ◽  
P. Mandel
Keyword(s):  
Olfactory Bulb ◽  
Glutamic Acid ◽  
Glutamic Acid Decarboxylase ◽  
Aminobutyric Acid ◽  
Acid Decarboxylase ◽  
Gamma Aminobutyric Acid ◽  
Gaba Transaminase ◽  
Semialdehyde Dehydrogenase ◽  
Succinate Semialdehyde

Stiff-person syndrome with acute recurrent peripheral vertigo: possible evidence of gamma aminobutyric acid as a neurotransmitter in the vestibular periphery

2007 ◽  
Vol 122 (6) ◽  
pp. 636-638 ◽  
Author(s):  
R Teggi ◽  
L O Piccioni ◽  
G Martino ◽  
C Bellini ◽  
M Bussi
Keyword(s):  
Glutamic Acid ◽  
Glutamic Acid Decarboxylase ◽  
Aminobutyric Acid ◽  
Acid Decarboxylase ◽  
Stiff Person Syndrome ◽  
Gamma Aminobutyric Acid ◽  
Vestibular Damage ◽  
Peripheral Vertigo

AbstractObjective:We report a case of a 58-year-old man suffering from stiff-person syndrome and recurrent peripheral vertigo.Method:A case report and a review of the recent literature on stiff-person syndrome are presented.Results:The patient presented with recurrent episodes of vertigo with a pure peripheral pattern and with concomitant episodes of burning muscle pain, muscle twitching, weight gain and fatigue, worsening with tension or stress that also occurred in periods without vertigo. Cochlear examinations only showed presbyacusis-like hearing loss. The diagnosis of stiff-person syndrome was made with electromyographic examination and from findings in the blood and cerebrospinal fluid of high titres of anti-glutamic acid decarboxylase (GAD67) autoantibodies. In a two-year follow-up period, therapy for stiff-person syndrome abolished episodes of both stiffness and vertigo.Conclusion:As far as we know, no other clinical case of acute vestibular damage with a possible correlation with anti-glutamic acid decarboxylase antibodies has been described. Peripheral vertigo possibly related to a lack of gamma aminobutyric acid underlines a possible role of gamma aminobutyric acid as a neurotransmitter in the peripheral vestibular system.

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